The Journal of Urology
Volume 185, Issue 4 , Pages 1388-1393 , April 2011

Regular Nonsteroidal Anti-Inflammatory Drug Use and Erectile Dysfunction

  • Joseph M. Gleason

      Affiliations

    • Department of Urology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California
    • Corresponding Author InformationCorrespondence: Department of Urology, Kaiser Permanente, LAMC, 4900 Sunset Blvd., 2nd Floor, Los Angeles, California 90027
    • ,
  • Jeffrey M. Slezak

      Affiliations

    • Department of Research and Evaluation, Kaiser Permanente Southern California, San Diego, California
    • ,
  • Howard Jung

      Affiliations

    • Department of Urology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California
    • ,
  • Kristi Reynolds

      Affiliations

    • Department of Research and Evaluation, Kaiser Permanente Southern California, San Diego, California
    • ,
  • Stephen K. Van Den Eeden

      Affiliations

    • Division of Research, Kaiser Permanente Northern California, Oakland, California
    • Financial interest and/or other relationship with Takada and GlaxoSmithKline.
    • ,
  • Reina Haque

      Affiliations

    • Department of Research and Evaluation, Kaiser Permanente Southern California, San Diego, California
    • ,
  • Virginia P. Quinn

      Affiliations

    • Department of Research and Evaluation, Kaiser Permanente Southern California, San Diego, California
    • ,
  • Ronald K. Loo

      Affiliations

    • Department of Urology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California
    • ,
  • Steven J. Jacobsen

      Affiliations

    • Department of Research and Evaluation, Kaiser Permanente Southern California, San Diego, California
    • Financial interest and/or other relationship with Kaiser Permanente and Merck.

Received 20 January 2010

References 

  1. Prins J , Blanker MH , Bohnen AM , et al.   Prevalence of erectile dysfunction: a systematic review of population-based studies . Int J Impotence Res . 2002;14:422
  2. Lue TF . Erectile dysfunction . N Engl J Med . 2000;342:1802
  3. Ponholzer A , Temmlb C , Mocka K , et al.   Prevalence and risk factors for erectile dysfunction in 2869 men using a validated questionnaire . Eur Urol . 2005;47:80
  4. Final Report on the Aspirin Component of the Ongoing Physicians' Health Study (Steering Committee of the Physicians' Health Study Research Group ) . N Engl J Med . 1989;321:129
  5. Inman BA , Sauver JL , Jacobson DJ , et al.   A population-based, longitudinal study of erectile dysfunction and future coronary artery disease . Mayo Clin Proc . 2009;84:108
  6. Lue TF . Physiology of penile erection and pathophysiology of erectile dysfunction . In:  Wein AJ ,  Kavoussi LR ,  Novick AC editor. Campbell-Walsh Urology . 9th ed.. New York: Elsevier; 2007; sect VI, chapt 21
  7. Blumentals WA , Gomez-Caminero A , Joo S , et al.   Should erectile dysfunction be considered as a marker for acute myocardial infarction? (Results from a retrospective cohort study ) . Int J Impotence Res . 2004;16:350
  8. Shiri R , Koskimäki J , Häkkinen J , et al.   Effect of nonsteroidal anti-inflammatory drug use on the incidence of erectile dysfunction . J Urol . 2006;175:1812
  9. Enger SM , Van DenEeden SK , Sternfeld B , et al.   California Men's Health Study (CMHS): a multiethnic cohort in a managed care setting . BMC Public Health . 2006;6:172
  10. Derby CA , Araujo AB , Johannes CB , et al.   Measurement of erectile dysfunction in population-based studies: the use of a single question self-assessment in the Massachusetts Male Aging Study . Int J Impotence Res . 2000;12:197
  11. O'Donnell AB , Araujo AB , Goldstein I , et al.   The validity of a single-question self-report of erectile dysfunction (Results from the Massachusetts Male Aging Study ) . J Gen Intern Med . 2005;20:515
  12. Smith JF , Caan BJ , Sternfeld B , et al.   Racial disparities in erectile dysfunction among participants in the California Men's Health Study . J Sex Med . 2009;6:3433
  13. Melman A , Gingell JC . The epidemiology and pathophysiology of erectile dysfunction . J Urol . 1999;161:5
  14. McVary KT . Erectile dysfunction . N Engl J Med . 2007;357:2472
  15. McKanna JA , Zhang MZ , Wang JL , et al.   Constitutive expression of cyclooxygenase-2 in rat vas deferens . Am J Physiol . 1998;275:227

 Study received approval from Kaiser Permanente Northern California and Southern California institutional review boards.

 Supported by the California Cancer Research Program (99-86883) and Kaiser Foundation Community Benefit Program.

PII: S0022-5347(10)05203-1

doi: 10.1016/j.juro.2010.11.092

The Journal of Urology
Volume 185, Issue 4 , Pages 1388-1393 , April 2011

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