The Journal of Urology
Volume 184, Issue 3 , Pages 938-943 , September 2010

[11C]Choline Positron Emission Tomography/Computerized Tomography to Restage Prostate Cancer Cases With Biochemical Failure After Radical Prostatectomy and No Disease Evidence on Conventional Imaging

  • Giampiero Giovacchini

      Affiliations

    • Center for Molecular Bioimaging, University of Milano-Bicocca, Milan, Italy
    • ,
  • Maria Picchio

      Affiliations

    • Department of Nuclear Medicine, San Raffaele Scientific Institute, Milan, Italy
    • Corresponding Author InformationCorrespondence: Department of Nuclear Medicine, San Raffaele Scientific Institute, Via Olgettina, 66, 20132 Milan, Italy (telephone: +39-02-2643-5456; FAX: +39-02-2643-3817)
    • ,
  • Alberto Briganti

      Affiliations

    • Department of Urology, San Raffaele Scientific Institute, Milan, Italy
    • ,
  • Cesare Cozzarini

      Affiliations

    • Department of Radiation Oncology, San Raffaele Scientific Institute, Milan, Italy
    • ,
  • Vincenzo Scattoni

      Affiliations

    • Department of Urology, San Raffaele Scientific Institute, Milan, Italy
    • ,
  • Andrea Salonia

      Affiliations

    • Department of Urology, San Raffaele Scientific Institute, Milan, Italy
    • ,
  • Claudio Landoni

      Affiliations

    • Department of Nuclear Medicine, San Raffaele Scientific Institute, Milan, Italy
    • ,
  • Luigi Gianolli

      Affiliations

    • Department of Nuclear Medicine, San Raffaele Scientific Institute, Milan, Italy
    • ,
  • Nadia Di Muzio

      Affiliations

    • Department of Radiation Oncology, San Raffaele Scientific Institute, Milan, Italy
    • ,
  • Patrizio Rigatti

      Affiliations

    • Department of Urology, San Raffaele Scientific Institute, Milan, Italy
    • ,
  • Francesco Montorsi

      Affiliations

    • Department of Urology, San Raffaele Scientific Institute, Milan, Italy
    • ,
  • Cristina Messa

      Affiliations

    • Center for Molecular Bioimaging, University of Milano-Bicocca, Milan, Italy
    • Institute for Bioimaging and Molecular Physiology, National Research Council, Milan, Italy
    • Department of Nuclear Medicine, San Gerardo Hospital, Monza, Italy

Received 15 December 2009

  • Image Result

    CT (A), PET (B) and fused PET/CT (C) show pathologically increased [11C]choline uptake in patient with right external iliac lymph node. No other pathological uptake sites were noted. Trigger PSA was 2

    CT (A), PET (B) and fused PET/CT (C) show pathologically increased [11C]choline uptake in patient with right external iliac lymph node. No other pathological uptake sites were noted. Trigger PSA was 2.68 ng/ml. Pelvic lymph nodal area was irradiated with 50 Gy during 5 weeks. PSA was undetectable 3 months after therapy end.

  • Image Result
    Positive [11C]choline PET/CT incidence in patients with PSA less than 1, between 1 and 2, and greater than 2 ng/ml.

    Positive [11C]choline PET/CT incidence in patients with PSA less than 1, between 1 and 2, and greater than 2 ng/ml.

 Study received approval from the Scientific Institute, San Raffaele Hospital ethical committee.

 For another article on a related topic see page 1211.

PII: S0022-5347(10)03519-6

doi: 10.1016/j.juro.2010.04.084

The Journal of Urology
Volume 184, Issue 3 , Pages 938-943 , September 2010

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