The Journal of Urology
Volume 184, Issue 3 , Pages 930-937 , September 2010

Smaller Prostate Size Predicts High Grade Prostate Cancer at Final Pathology

  • Mark R. Newton

      Affiliations

    • Department of Urology, University of Iowa, Iowa City, Iowa
  • ,
  • Sharon Phillips

      Affiliations

    • Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee
  • ,
  • Sam S. Chang

      Affiliations

    • Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee
    • Financial interest and/or other relationship with Endo, Sanofi-Aventis and Allergan.
  • ,
  • Peter E. Clark

      Affiliations

    • Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee
  • ,
  • Michael S. Cookson

      Affiliations

    • Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee
    • Financial interest and/or other relationship with Sanofi, Amgen, Watson, Endo and GSK.
  • ,
  • Rodney Davis

      Affiliations

    • Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee
  • ,
  • Jay H. Fowke

      Affiliations

    • Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee
  • ,
  • S. Duke Herrell

      Affiliations

    • Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee
  • ,
  • Roxelyn Baumgartner

      Affiliations

    • Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee
  • ,
  • Robert Chan

      Affiliations

    • Department of Urology, Baylor College of Medicine, Houston, Texas
  • ,
  • Vineet Mishra

      Affiliations

    • Department of Urology, Emory University School of Medicine, Atlanta, Georgia
  • ,
  • Jeffrey D. Blume

      Affiliations

    • Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee
  • ,
  • Joseph A. Smith Jr.

      Affiliations

    • Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee
  • ,
  • Daniel A. Barocas

      Affiliations

    • Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee
    • Corresponding Author InformationCorrespondence: Department of Urologic Surgery, Vanderbilt University Medical Center, A-1302 Medical Center North, Nashville, Tennessee 37205 (telephone: 615-322-2101; FAX: 615-322-8990)
    • Financial interest and/or other relationship with Ferring.

Received 21 December 2009

References 

  1. Thompson IM, Goodman PJ, Tangen CM, et al. The influence of finasteride on the development of prostate cancer. N Engl J Med. 2003;349:215
  2. Briganti A, Chun FK, Suardi N, et al. Prostate volume and adverse prostate cancer features: fact not artifact. Eur J Cancer. 2007;43:2669
  3. Freedland SJ, Isaacs WB, Platz EA, et al. Prostate size and risk of high-grade, advanced prostate cancer and biochemical progression after radical prostatectomy: a search database study. J Clin Oncol. 2005;23:7546
  4. Kulkarni GS, Al-Azab R, Lockwood G, et al. Evidence for a biopsy derived grade artifact among larger prostate glands. J Urol. 2006;175:505
  5. Kassouf W, Nakanishi H, Ochiai A, et al. Effect of prostate volume on tumor grade in patients undergoing radical prostatectomy in the era of extended prostatic biopsies. J Urol. 2007;178:111
  6. Epstein JI, Srigley J, Grignon D, et al. Recommendations for the reporting of prostate carcinoma: Association of Directors of Anatomic and Surgical Pathology. Am J Clin Pathol. 2008;129:24
  7. Harrell FE. Relaxing linearity assumption for continuous predictors. In: Regression Modeling Strategies. New York: Springer-Verlag; 2001;p. 16–26
  8. Horton N, Lipsitz S. Multiple imputation in practice. Am Stat. 2001;55:244
  9. Lucia MS, Epstein JI, Goodman PJ, et al. Finasteride and high-grade prostate cancer in the Prostate Cancer Prevention Trial. J Natl Cancer Inst. 2007;99:1375
  10. Han M, Partin AW, Pound CR, et al. Long-term biochemical disease-free and cancer-specific survival following anatomic radical retropubic prostatectomy (The 15-year Johns Hopkins experience). Urol Clin North Am. 2001;28:555
  11. Pisansky TM, Kahn MJ, Rasp GM, et al. A multiple prognostic index predictive of disease outcome after irradiation for clinically localized prostate carcinoma. Cancer. 1997;79:337
  12. Makarov DV, Trock BJ, Humphreys EB, et al. Updated nomogram to predict pathologic stage of prostate cancer given prostate-specific antigen level, clinical stage, and biopsy Gleason score (Partin tables) based on cases from 2000 to 2005. Urology. 2007;69:1095
  13. Kattan MW, Eastham JA, Stapleton AM, et al. A preoperative nomogram for disease recurrence following radical prostatectomy for prostate cancer. J Natl Cancer Inst. 1998;90:766
  14. Bianco FJ, Mallah KN, Korets R, et al. Prostate volume measured preoperatively predicts for organ-confined disease in men with clinically localized prostate cancer. Urology. 2007;69:343
  15. Shariat S, Karakiewicz PI, Roehrborn CG, et al. An updated catalog of prostate cancer predictive tools. Cancer. 2008;113:3075
  16. Kulkarni G, Lockwood G, Evans A, et al. Clinical predictors of Gleason score upgrading: implications for patients considering watchful waiting, active surveillance, or brachytherapy. Cancer. 2007;109:2432
  17. Bangma CH, Roobol MJ, Steyerberg EW. Predictive models in diagnosing indolent cancer. Cancer. 2009;115:3100
  18. Goto Y, Ohori M, Arakawa A, et al. Distinguishing clinically important from unimportant prostate cancers before treatment: value of systematic biopsies. J Urol. 1996;156:1059
  19. Epstein JI, Walsh PC, Carmichael M, et al. Pathologic and clinical findings to predict tumor extent of nonpalpable (stage T1c) prostate cancer. JAMA. 1994;271:368
  20. Steyerberg E, Roobol M, Kattan M, et al. Prediction of indolent prostate cancer: validation and updating of a prognostic nomogram. J Urol. 2007;177:107
  21. Quan A, Ciezki J, Reddy C, et al. Improved biochemical relapse-free survival for patients with large/wide glands treated with prostate seed implantation for localized adenocarcinoma of prostate. Urology. 2006;68:1237
  22. Lehrer S, Stone NN, Stock RG. Prostate cancer in a large prostate is associated with a decreased prostate specific antigen failure rate after brachytherapy. J Urol. 2005;173:79
  23. Roach M, Waldman F, Pollack A. Predictive models in external beam radiotherapy for clinically localized prostate cancer. Cancer. 2009;115:3112
  24. Kattan MW, Zelefsky MJ, Kupelian PA, et al. Pretreatment nomogram for predicting the outcome of three-dimensional conformal radiotherapy in prostate cancer. J Clin Oncol. 2000;18:3352
  25. Zelefsky MJ, Lyass O, Fuks Z, et al. Predictors of improved outcome for patients with localized prostate cancer treated with neoadjuvant androgen ablation therapy and three-dimensional conformal radiotherapy. J Clin Oncol. 1998;16:3380
  26. Nguyen CT, Zelefsky MJ, Kattan MW. The current state of brachytherapy nomograms for patients with clinically localized prostate cancer. Cancer. 2009;115:3121
  27. Kattan MW, Potters L, Blasko JC, et al. Pretreatment nomogram for predicting freedom from recurrence after permanent prostate brachytherapy in prostate cancer. Urology. 2001;58:393
  28. Potters L, Roach M, Davis BJ, et al. Postoperative nomogram predicting the 9-year probability of prostate cancer recurrence after permanent prostate brachytherapy using radiation dose as a prognostic variable. Int J Radiat Oncol Biol Phys. 2010;76:1061
  29. Dong F, Jones JS, Stephenson AJ, et al. Prostate cancer volume at biopsy predicts clinically significant upgrading. J Urol. 2008;179:896
  30. Rahmouni A, Yang A, Tempany CM, et al. Accuracy of in-vivo assessment of prostatic volume by MRI and transrectal ultrasonography. J Comput Assist Tomogr. 1992;16:935

 Study received institutional review board approval.

 For another article on a related topic see page 1211.

PII: S0022-5347(10)03517-2

doi: 10.1016/j.juro.2010.04.082

The Journal of Urology
Volume 184, Issue 3 , Pages 930-937 , September 2010