The Journal of Urology
Volume 184, Issue 2 , Pages 494-500 , August 2010

The Association Between Statin Use and the Diagnosis of Prostate Cancer in a Population Based Cohort

  • Rodney H. Breau

      Affiliations

    • Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota
    • ,
  • R. Jeffrey Karnes

      Affiliations

    • Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota
    • ,
  • Debra J. Jacobson

      Affiliations

    • Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota
    • ,
  • Michaela E. McGree

      Affiliations

    • Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota
    • ,
  • Steven J. Jacobsen

      Affiliations

    • Southern California Permanente Medical Group, Pasadena, California
    • Financial interest and/or other relationship with Kaiser Permanente and Merck.
    • ,
  • Ajay Nehra

      Affiliations

    • Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota
    • Financial interest and/or other relationship with GlaxoSmithKline, Pfizer and Sanofi-Aventis Medical.
    • ,
  • Michael M. Lieber

      Affiliations

    • Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota
    • ,
  • Jennifer L. St. Sauver

      Affiliations

    • Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota
    • Corresponding Author InformationCorrespondence and requests for reprints: Department of Health Sciences Research, Mayo Clinic, 200 First St. SW, Rochester, Minnesota 55901 (telephone: 507-538-1460; FAX: 507-284-1516)

Received 11 December 2009

  • Image Result

    Study participation in each round of followup

    Study participation in each round of followup

  • Image Result

    Cumulative incidence of exceeding age specific PSA reference range (A), of prostate biopsy (B), of prostate cancer (C) and of high grade prostate cancer (Gleason 7 or greater, D).

    Cumulative incidence of exceeding age specific PSA reference range (A), of prostate biopsy (B), of prostate cancer (C) and of high grade prostate cancer (Gleason 7 or greater, D).

  • Image Result

    Associations between duration of statin use (stratified by tertiles) and outcome using nonstatin users as referent group. P values represent tests for trend. Asterisk indicates PSA outcomes only for 6

    Associations between duration of statin use (stratified by tertiles) and outcome using nonstatin users as referent group. P values represent tests for trend. Asterisk indicates PSA outcomes only for 634 men who participated in in-clinic examinations. Double asterisk indicates adjusted for age, diabetes, hypertension, CHD, and NSAID, 5α-reductase inhibitor and α-blocker use.

 Supported by the U.S. Public Health Service, National Institutes of Health (Grants DK58859, AR30582 and 1 UL1 RR024150-01) and Merck Research Laboratory.

 See Editorial on page 415.

PII: S0022-5347(10)03277-5

doi: 10.1016/j.juro.2010.03.149

The Journal of Urology
Volume 184, Issue 2 , Pages 494-500 , August 2010

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