The Journal of Urology
Volume 184, Issue 2 , Pages 598-603 , August 2010

Combined Behavioral and Individualized Drug Therapy Versus Individualized Drug Therapy Alone for Urge Urinary Incontinence in Women

  • Kathryn L. Burgio

      Affiliations

    • Birmingham/Atlanta Geriatric Research Education and Clinical Center, Department of Veterans Affairs, Birmingham, Alabama and Atlanta, Georgia
    • University of Alabama at Birmingham, Birmingham, Alabama
    • Corresponding Author InformationCorrespondence: Birmingham VA Medical Center, GRECC/11G, 700 19th St. S., Birmingham, Alabama 35233
    • Financial interest and/or other relationship with Pfizer and Astellas.
    • ,
  • Patricia S. Goode

      Affiliations

    • Birmingham/Atlanta Geriatric Research Education and Clinical Center, Department of Veterans Affairs, Birmingham, Alabama and Atlanta, Georgia
    • University of Alabama at Birmingham, Birmingham, Alabama
    • Financial interest and/or other relationship with Pfizer.
    • ,
  • Holly E. Richter

      Affiliations

    • University of Alabama at Birmingham, Birmingham, Alabama
    • Financial interest and/or other relationship with Xanodyne, Pfizer and Astellas.
    • ,
  • Alayne D. Markland

      Affiliations

    • Birmingham/Atlanta Geriatric Research Education and Clinical Center, Department of Veterans Affairs, Birmingham, Alabama and Atlanta, Georgia
    • University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • Theodore M. Johnson II

      Affiliations

    • Birmingham/Atlanta Geriatric Research Education and Clinical Center, Department of Veterans Affairs, Birmingham, Alabama and Atlanta, Georgia
    • Emory University, Atlanta, Georgia
    • Financial interest and/or other relationship with Aventis, Yamanouchi, Ortho McNeil, Boehringer Ingelheim, Johnson & Johnson and Pfizer.
    • ,
  • David T. Redden

      Affiliations

    • Birmingham/Atlanta Geriatric Research Education and Clinical Center, Department of Veterans Affairs, Birmingham, Alabama and Atlanta, Georgia
    • University of Alabama at Birmingham, Birmingham, Alabama

Received 10 October 2009

References 

  1. Milsom I, Altman D, Lapitan MC, et al. Epidemiology of urinary (UI) and faecal (FI) incontinence and pelvic organ prolapse. In:  Abrams P,  Cardozo L,  Khoury S, et al. editor. 4th International Consultation on Incontinence. Paris: Health Publications Ltd; 2009;p. 35–112
  2. Coyne KS, Zhou Z, Thompson C, et al. The impact on health-related quality of life of stress, urge and mixed urinary incontinence. BJU Int. 2003;92:731
  3. Andersson KE. Antimuscarinics for treatment of overactive bladder. Lancet Neurol. 2004;3:46
  4. MacDiarmid SA. Maximizing anticholinergic therapy for overactive bladder: has the ceiling been reached?. BJU Int. 2007;99:8
  5. MacDiarmid SA, Anderson RU, Armstrong RB, et al. Efficacy and safety of extended release oxybutynin for the treatment of urge incontinence: an analysis of data from 3 flexible dosing studies. J Urol. 2005;174:1301
  6. Burgio KL, Whitehead WE, Engel BT. Urinary incontinence in the elderly (Bladder-sphincter biofeedback and toileting skills training). Ann Intern Med. 1985;103:507
  7. Burgio KL, Locher JL, Goode PS, et al. Behavioral vs drug treatment for urge urinary incontinence in older women: a randomized controlled trial. JAMA. 1998;280:1995
  8. Burgio KL, Goode PS, Locher JL, et al. Behavioral training with and without biofeedback in the treatment of urge incontinence in older women: a randomized controlled trial. JAMA. 2002;288:2293
  9. Burton JR, Pearce KL, Burgio KL, et al. Behavioral training for urinary incontinence in elderly ambulatory patients. J Am Geriatr Soc. 1988;36:693
  10. Baigis-Smith J, Smith DA, Rose M, et al. Managing urinary incontinence in community-residing elderly persons. Gerontologist. 1989;29:229
  11. McDowell BJ, Burgio KL, Dombrowski M, et al. An interdisciplinary approach to the assessment and behavioral treatment of urinary incontinence in geriatric outpatients. J Am Geriatr Soc. 1992;40:370
  12. Burgio KL, Locher JL, Goode PS. Combined behavioral and drug therapy for urge incontinence in older women. J Am Geriatr Soc. 2000;48:370
  13. Goode PS, Burgio KL, Locher JL, et al. Urodynamic changes associated with behavioral and drug treatment of urge incontinence in older women. J Am Geriatr Soc. 2002;50:808
  14. Locher JL, Goode PS, Roth DL, et al. Reliability assessment of the bladder diary for urinary incontinence in older women. J Gerontol A Biol Sci Med Sci. 2001;56:M32
  15. Burgio KL, Goode PS, Richter HE, et al. Global ratings of patient satisfaction and perceptions of improvement with treatment for urinary incontinence: validation of three global patient ratings. Neurourol Urodyn. 2006;25:411
  16. Shumaker SA, Wyman JF, Uebersax JS, et al. Health-related quality of life measures for women with urinary incontinence: the Incontinence Impact Questionnaire and the Urogenital Distress Inventory. Qual Life Res. 1994;3:291
  17. Dmitrienko A, Molenberghs G, Chuang-Stein C, et al. Analysis of Clinical Trials Using SAS: A Practical Guide. Cary: SAS Institute Inc; 2005;
  18. Jennison C, Turnbull BW. Group Sequential Methods with Applications to Clinical Trials. Boca Raton: Chapman and Hall/CRC; 2000;
  19. Yu YF, Nichol MB, Yu AP, et al. Persistence and adherence of medications for chronic overactive bladder/urinary incontinence in the California Medicaid program. Value Health. 2005;8:495
  20. Millard RJ Asia Pacific Tolterodine Study Group. Clinical efficacy of tolterodine with or without a simplified pelvic floor exercise regimen. Neurourol Urodyn. 2004;23:48
  21. Chancellor MB, Kianifard F, Beamer E, et al. A comparison of the efficacy of darifenacin alone vs. darifenacin plus a behavioural modification programme upon the symptoms of overactive bladder. Int J Clin Pract. 2008;62:606
  22. Mattiasson A, Blaakaer J, Hoye K, et al. Simplified bladder training augments the effectiveness of tolterodine in patients with an overactive bladder. BJU Int. 2003;91:54
  23. Mattiasson A, Masala A, Morton R, et al. Efficacy of simplified bladder training in patients with overactive bladder receiving a solifenacin flexible-dose regimen: results from a randomized study. BJU Int. 2009;Epub ahead of print
  24. Burgio KL, Kraus SR, Menefee S, et al. Behavioral therapy to enable women with urge incontinence to discontinue drug treatment: a randomized trial. Ann Intern Med. 2008;149:161

 Supported by a grant from the Department of Veterans Affairs, Veterans Health Administration, Rehabilitation Research and Development Service, and the Female Veterans Project, Birmingham/Atlanta Geriatric Research Education and Clinical Center, Birmingham VA Medical Center.

 Study received institutional review board approval.

 Supplementary material for this article can be obtained at http://www.research.va.gov/publications/burgio-et-al.cfm.

 For another article on a related topic see page 783.

PII: S0022-5347(10)03268-4

doi: 10.1016/j.juro.2010.03.141

The Journal of Urology
Volume 184, Issue 2 , Pages 598-603 , August 2010

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