The Journal of Urology
Volume 184, Issue 2 , Pages 790-796 , August 2010

Preventive Effects of Cyclosporine A Combined With Prednisolone and Melatonin on Contralateral Testicular Damage After Ipsilateral Torsion-Detorsion in Pubertal and Adult Rats

  • Seong Jin Jeong

      Affiliations

    • Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea
    • ,
  • Woo Suk Choi

      Affiliations

    • Department of Urology, Seoul National University Hospital, Seoul, Korea
    • ,
  • Jae-Seung Chung

      Affiliations

    • Department of Urology, Pochon Cha University, Bundang Cha Hospital, Seongnam, Korea
    • ,
  • Minki Baek

      Affiliations

    • Department of Urology, Konkuk University Medical Center, Seoul, Korea
    • ,
  • Sung Kyu Hong

      Affiliations

    • Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea
    • ,
  • Hwang Choi

      Affiliations

    • Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea
    • Department of Urology, Pochon Cha University, Bundang Cha Hospital, Seongnam, Korea
    • Department of Urology, Seoul National University Hospital, Seoul, Korea
    • Department of Urology, Konkuk University Medical Center, Seoul, Korea
    • Corresponding Author InformationCorrespondence: Department of Urology, Seoul National University Children's Hospital, 28 Yongon-dong, Chongno-gu, Seoul, Korea 110-744 (telephone: +82-2-2072-2428; FAX: +82-2-742-4665)

Received 7 November 2009

References 

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  4. Karaguzel G, Gedikoglu G, Tanyel FC, et al. Subsequent biological effects of chemical sympathectomy in rats undergoing unilateral testicular torsion. Eur Urol. 1995;28:147
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  9. Tanyel FC, Buyukpamukcu N, Hicsonmez A. Contralateral testicular blood flow during unilateral testicular torsion. Br J Urol. 1989;63:522
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  11. Lysiak JJ, Turner SD, Turner TT. Molecular pathway of germ cell apoptosis following ischemia/reperfusion of the rat testis. Biol Reprod. 2000;63:1465
  12. Clermont Y, Perey B. Quantitative study of the cell population of the seminiferous tubules in immature rats. Am J Anat. 1957;100:241
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  15. Abasiyanik A, Dağdönderen L. Beneficial effects of melatonin compared with allopurinol in experimental testicular torsion. J Pediatr Surg. 2004;39:1238
  16. Madarikan BA. Testicular salvage following spermatic cord torsion. J Pediatr Surg. 1987;22:231
  17. Gülmez I, Karacagil M, Sade M, et al. Effect of testicular torsion on the contralateral testis and prevention of this effect by prednisolone. Eur Urol. 1987;13:340
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  19. Yurtçu M, Abasiyanik A, Avunduk MC, et al. Effects of melatonin on spermatogenesis and testicular ischemia-reperfusion injury after unilateral testicular torsion-detorsion. J Pediatr Surg. 2008;43:1873
  20. Rodriguez MG, Rival C, Theas MS, et al. Immunohistopathology of the contralateral testis of rats undergoing experimental torsion of the spermatic cord. Asian J Androl. 2006;8:576
  21. Hess AD, Tutschka PJ, Santos GW. Effect of cyclosporin A on human lymphocyte responses in vitro (III. CsA inhibits the production of T lymphocyte growth factors in secondary mixed lymphocyte responses but does not inhibit the response of primed lymphocytes to TCGF). J Immunol. 1982;128:355
  22. Bulkley GB. Free radical-mediated reperfusion injury: a selective review. Br J Cancer. 1987;8(suppl.):66
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  24. Schoenberg MH, Beger HG. Reperfusion injury after intestinal ischemia. Crit Care Med. 1993;21:1376
  25. Duru FI, Noronha CC, Akinwande AI, et al. Effects of torsion, detorsion and melatonin on testicular malondialdehyde level. West Afr J Med. 2007;26:312
  26. Hekimoglu A, Kurcer Z, Aral F, et al. Lycopene, an antioxidant carotenoid, attenuates testicular injury caused by ischemia/reperfusion in rats. Tohoku J Exp Med. 2009;218:141
  27. Cuzzocrea S, Zingarelli B, Gilad E, et al. Protective effect of melatonin in carrageenan-induced models of local inflammation: relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity. J Pineal Res. 1997;23:106
  28. Park EC, Kwak C, Son H, et al. The role of clusterin in apoptosis induced by testicular torsion. Korean J Urol. 2004;45:380

 Study received approval from the Seoul National University Hospital Clinical Research Institute institutional animal care and use committee.

 Supported by Seoul National University Hospital Research Fund Grant 21-2005-018.

PII: S0022-5347(10)03207-6

doi: 10.1016/j.juro.2010.03.109

The Journal of Urology
Volume 184, Issue 2 , Pages 790-796 , August 2010

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