The Journal of Urology
Volume 184, Issue 2 , Pages 762-768 , August 2010

α2-Adrenoceptor Blockade Potentiates the Effect of Duloxetine on Sneeze Induced Urethral Continence Reflex in Rats

  • Takeya Kitta

      Affiliations

    • Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    • Department of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    • ,
  • Minoru Miyazato

      Affiliations

    • Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    • ,
  • Michael B. Chancellor

      Affiliations

    • William Beaumont Hospital, Royal Oak, Michigan
    • ,
  • William C. de Groat

      Affiliations

    • Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    • ,
  • Katsuya Nonomura

      Affiliations

    • Department of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    • ,
  • Naoki Yoshimura

      Affiliations

    • University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    • Corresponding Author InformationCorrespondence: Department of Urology, University of Pittsburgh School of Medicine, Suite 700, Kaufmann Medical Building, 3471 Fifth Ave., Pittsburgh, Pennsylvania 15213 (telephone: 412-692-4137; FAX: 412-692-4380)

Received 15 October 2009

References 

  1. Swithinbank LV, Abrams P. The impact of urinary incontinence on the quality of life of women. World J Urol. 1999;17:225
  2. Hunskaar S, Burgio K, Diokno A, et al. Epidemiology and natural history of urinary incontinence in women. Urology. 2003;62:16
  3. Landefeld CS, Bowers BJ, Feld AD, et al. National Institutes of Health state-of-the-science conference statement: prevention of fecal and urinary incontinence in adults. Ann Intern Med. 2008;148:449
  4. Hannestad YS, Rortveit G, Sandvik H, et al. A community-based epidemiological survey of female urinary incontinence: the Norwegian EPINCONT study (Epidemiology of Incontinence in the County of Nord-Trondelag). J Clin Epidemiol. 2000;53:1150
  5. Diokno AC, Brock BM, Brown MB, et al. Prevalence of urinary incontinence and other urological symptoms in the noninstitutionalized elderly. J Urol. 1986;136:1022
  6. Shamliyan TA, Kane RL, Wyman J, et al. Systematic review: randomized, controlled trials of nonsurgical treatments for urinary incontinence in women. Ann Intern Med. 2008;148:459
  7. Gahimer J, Wernicke J, Yalcin I, et al. A retrospective pooled analysis of duloxetine safety in 23,983 subjects. Curr Med Res Opin. 2007;23:175
  8. Kamo I, Torimoto K, Chancellor MB, et al. Urethral closure mechanisms under sneeze-induced stress condition in rats: a new animal model for evaluation of stress urinary incontinence. Am J Physiol Regul Integr Comp Physiol. 2003;285:R356
  9. Miyazato M, Kaiho Y, Kamo I, et al. Effect of duloxetine, a norepinephrine and serotonin reuptake inhibitor, on sneeze-induced urethral continence reflex in rats. Am J Physiol Renal Physiol. 2008;295:F264
  10. Furuta A, Asano K, Egawa S, et al. Role of α2-adrenoceptors and glutamate mechanisms in the external urethral sphincter continence reflex in rats. J Urol. 2009;181:19
  11. Lin AS, Carrier S, Morgan DM, et al. Effect of simulated birth trauma on the urinary continence mechanism in the rat. Urology. 1998;52:143
  12. Kamo I, Kaiho Y, Canon TW, et al. Functional analysis of active urethral closure mechanisms under sneeze induced stress condition in a rat model of birth trauma. J Urol. 2006;176:2711
  13. McClish DK, Wyman JF, Sale PG, et al. Use and costs of incontinence pads in female study volunteers (Continence Program for Women Research Group). J Wound Ostomy Continence Nurs. 1999;26:207–208210
  14. Doran CM, Chiarelli P, Cockburn J. Economic costs of urinary incontinence in community-dwelling Australian women. Med J Aust. 2001;174:456
  15. Turner DA, Shaw C, McGrother CW, et al. The cost of clinically significant urinary storage symptoms for community dwelling adults in the UK. BJU Int. 2004;93:1246
  16. Morkved S, Bo K. Effect of postpartum pelvic floor muscle training in prevention and treatment of urinary incontinence: a one-year follow up. BJOG. 2000;107:1022
  17. Rezapour M, Ulmsten U. Tension-free vaginal tape (TVT) in women with recurrent stress urinary incontinence—a long-term follow up. Int Urogynecol J Pelvic Floor Dysfunct. 2001;2(suppl.):S9
  18. Groutz A, Gold R, Pauzner D, et al. Tension-free vaginal tape (TVT) for the treatment of occult stress urinary incontinence in women undergoing prolapse repair: a prospective study of 100 consecutive cases. Neurourol Urodyn. 2004;23:632
  19. Gerten KA, Markland AD, Lloyd LK, et al. Prolapse and incontinence surgery in older women. J Urol. 2008;179:2111
  20. Gordon D, Gold R, Pauzner D, et al. Tension-free vaginal tape in the elderly: is it a safe procedure?. Urology. 2005;65:479
  21. Dugan SE, Fuller MA. Duloxetine: a dual reuptake inhibitor. Ann Pharmacother. 2004;38:2078
  22. Detke MJ, Wiltse CG, Mallinckrodt CH, et al. Duloxetine in the acute and long-term treatment of major depressive disorder: a placebo- and paroxetine-controlled trial. Eur Neuropsychopharmacol. 2004;14:457
  23. Voelker R. International group seeks to dispel incontinence “taboo.”. JAMA. 1998;280:951
  24. Norton PA, Zinner NR, Yalcin I, et al. Duloxetine versus placebo in the treatment of stress urinary incontinence. Am J Obstet Gynecol. 2002;187:40
  25. Dmochowski RR, Miklos JR, Norton PA, et al. Duloxetine versus placebo for the treatment of North American women with stress urinary incontinence. J Urol. 2003;170:1259
  26. Duckett J. Duloxetine as a treatment for stress incontinence—where are we now?. Int Urogynecol J Pelvic Floor Dysfunct. 2008;19:1
  27. Thor KB, Katofiasc MA. Effects of duloxetine, a combined serotonin and norepinephrine reuptake inhibitor, on central neural control of lower urinary tract function in the chloralose-anesthetized female cat. J Pharmacol Exp Ther. 1995;274:1014
  28. Kaiho Y, Kamo I, Chancellor MB, et al. Role of noradrenergic pathways in sneeze-induced urethral continence reflex in rats. Am J Physiol Renal Physiol. 2007;292:F639
  29. Danuser H, Bemis K, Thor KB. Pharmacological analysis of the noradrenergic control of central sympathetic and somatic reflexes controlling the lower urinary tract in the anesthetized cat. J Pharmacol Exp Ther. 1995;274:820
  30. Piletz JE, Zhu H, Chikkala DN. Comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes. J Pharmacol Exp Ther. 1996;279:694

 Study received University of Pittsburgh institutional animal care and use committee approval.

 Supported by National Institutes of Health Grants DK067226, AR049398 and DK055387.

PII: S0022-5347(10)03204-0

doi: 10.1016/j.juro.2010.03.106

The Journal of Urology
Volume 184, Issue 2 , Pages 762-768 , August 2010

Article Tools

* Image Usage & Resolution