The Journal of Urology
Volume 184, Issue 2 , Pages 696-701 , August 2010

Sacral Neuromodulation in Children With Urinary and Fecal Incontinence: A Multicenter, Open Label, Randomized, Crossover Study

  • M. Haddad

      Affiliations

    • Department of Pediatric Surgery, Hôpital d'Enfants de la Timone, Marseille, France
    • Corresponding Author InformationCorrespondence: Department of Pediatric Surgery, Hôpital d'Enfants de la Timone 264, rue Saint Pierre, 13005 Marseille Cedex 5, France (telephone: 33-4-91-38-66-82; FAX: 33-4-91-38-47-14)
    • ,
  • R. Besson

      Affiliations

    • Department of Pediatric Surgery, Hôpital Jeanne de Flandre, Lille, France
    • ,
  • D. Aubert

      Affiliations

    • Department of Pediatric Surgery, Hôpital Saint Jacques, Besançon, France
    • ,
  • P. Ravasse

      Affiliations

    • Department of Pediatric Surgery, CHU Caen, Caen, France
    • ,
  • J. Lemelle

      Affiliations

    • Department of Pediatric Surgery, CHU Nancy, Nancy, France
    • ,
  • A. El Ghoneimi

      Affiliations

    • Department of Pediatric Surgery, Hôpital Robert Debré, Paris, France
    • ,
  • J. Moscovici

      Affiliations

    • Department of Pediatric Surgery, Hôpital des Enfants, Toulouse, France
    • ,
  • F. Hameury

      Affiliations

    • Department of Pediatric Surgery, CHU Lyon, Lyon, France
    • ,
  • K. Baumstarck-Barrau

      Affiliations

    • Department of Public Health, Université de la Méditérranée, Marseille, France
    • ,
  • G. Hery

      Affiliations

    • Department of Pediatric Surgery, Hôpital d'Enfants de la Timone, Marseille, France
    • ,
  • J.M. Guys

      Affiliations

    • Department of Pediatric Surgery, Hôpital d'Enfants de la Timone, Marseille, France

Received 30 October 2009

References 

  1. Nijman RJ, Tekgul S. Pathophysiology of neurogenic bladder dysfunction. In:  Esposito C,  Guys JM,  Gough D editor. Pediatric Neurogenic Bladder Dysfunction—Diagnosis, Treatment, Long-Term Follow-Up. New York: Springer; 2006;p. 33;chapt 4
  2. Ponticelli A, Iacobelli BD, Silveri M. Colorectal dysfunction and faecal incontinence in children with spina bifida. Br J Urol. 1998;81(suppl.):117
  3. Matzel KE, Stadelmaier U, Hohenfellner M. Electrical stimulation of sacral nerves for treatment of faecal incontinence. Lancet. 1995;346:1124
  4. Bosch JL, Groen J. Sacral nerve modulation in the treatment of patients with refractory motor urge incontinence: long-terms results of a prospective longitudinal study. J Urol. 2000;163:1219
  5. Indar A, Young-Fadok T, Cornella J. A dual benefit of sacral neuromodulation. Surg Innov. 2008;15:219
  6. Tjandra JJ, Lim JF, Matzel K. Sacral nerve stimulation: an emerging treatment for fecal incontinence. Aust N Z J Surg. 2004;74:1098
  7. Fandel T, Tanagho EA. Neuromodulation in voiding dysfunction: a historical overview of neurostimulation and its application. Urol Clin North Am. 2005;32:1
  8. Bernstein AJ, Peters KM. Expanding indications for neuromodulation. Urol Clin North Am. 2005;32:59
  9. Guys JM, Haddad M, Planche D, et al. Sacral neuromodulation for neurogenic bladder dysfunction in children. J Urol. 2004;172:1673
  10. Roth TJ, Vandersteen DV, Hollatz P, et al. Sacral neuromodulation for dysfunctional elimination syndrome: a single center experience with 20 children. J Urol. 2008;180:306
  11. Hoebeke P, Van Laecke E, Everaert K, et al. Transcutaneous neuromodulation for the urge syndrome in children: a pilot study. J Urol. 2006;166:2416
  12. Abrahams P, Blaivas JG, Stanton SL, et al. The standardisation of terminology of lower urinary tract function. Scand J Urol Nephrol. 1998;114:5
  13. Everaert K, Plancke H, Lefevere F, et al. The urodynamic evaluation of neuromodulation in patients with voiding dysfunction. Br J Urol. 1997;79:702
  14. Scheepens WA, Jongen MM, Nieman FH, et al. Predictive factors for sacral neuromodulation in chronic lower urinary tract dysfunction. Urology. 2002;60:598
  15. Keppene V, Mozer P, Chartier-Kastler E, et al. Neuromodulation in the management of neurogenic lower urinary tract dysfunction. Prog Urol. 2007;17:609
  16. Lombardi G, Del Popolo G, Cecconi F, et al. Clinical outcome of sacral neuromodulation in incomplete spinal cord-injured patients suffering from neurogenic bowel dysfunctions. Spinal Cord. 2009;11:101
  17. Guys JM, Breaud J, Hery G, et al. Endoscopic injection with polydimethylsiloxane for the treatment of pediatric urinary incontinence in the neurogenic bladder: long-term results. J Urol. 2006;175:1106
  18. Lottmann HB, Margaryan M, Bernuy M, et al. The effect of endoscopic injections of dextranomer based implants on continence and bladder capacity: a prospective study of 31 patients. J Urol. 2002;168:1863
  19. Faucheron JL, Bost R, Duffournet V, et al. Sacral neuromodulation in the treatment of severe anal incontinence (Forty consecutive cases treated in one institution). Gastroenterol Clin Biol. 2006;30:669
  20. Uludag O, Koch SM, Van Gemert WG, et al. Sacral neuromodulation in patients with fecal incontinence: a single-center study. Dis Colon Rectum. 2004;47:1350
  21. Leroi AM, Michot F, Grise P, et al. Effect of sacral nerve stimulation in patients with fecal and urinary incontinence. Dis Colon Rectum. 2001;44:779
  22. Matzel KE, Stadelmaier U, Hohenfellner M, et al. Chronic sacral spinal nerve stimulation for fecal incontinence: long-term results with foramen and cuff electrodes. Dis Colon Rectum. 2001;44:59
  23. Ripetti V, Caputo D, Ausania F, et al. Sacral nerve neuromodulation improves physical, psychological and social quality of life in patients with fecal incontinence. Tech Coloproctol. 2002;6:147
  24. Michelsen HB, Christensen P, Krogh K, et al. Sacral nerve stimulation for faecal incontinence alters colorectal transport. Br J Surg. 2008;95:779
  25. Dinning PG, Fuentealba SE, Kennedy ML, et al. Sacral nerve stimulation induces pan-colonic propagating pressure waves and increases defecation frequency in patients with slow-transit constipation. Colorectal Dis. 2007;9:123
  26. Uludag O, Morren GL, Dejong CH, et al. Effect of sacral neuromodulation on the rectum. Br J Surg. 2005;92:1017
  27. Vitton V, Gigout J, Grimaud JC, et al. Sacral nerve stimulation can improve incontinence in Crohn's patients with internal and external sphincter disruption. Dis Colon Rectum. 2008;51:924
  28. Boyle DJ, Knowles CH, Lunniss PJ, et al. Efficacy of sacral nerve stimulation for fecal incontinence in patients with anal sphincter defects. Dis Colon Rectum. 2009;52:1234
  29. Blok BF, Groen J, Bosch JL, et al. Different brain effects during chronic and acute sacral neuromodulation in urge incontinent patients with implanted neurostimulators. BJU Int. 2006;98:1238
  30. Kavia R, Dasqupta R, Critchley H, et al. A functional magnetic resonance imaging study of the effect of sacral neuromodulation on brain responses in women with Fowler's syndrome. BJU Int. 2010;105:366

 See Editorial on page 417.

 Study protocol was approved by a French ethics committee and registered as a clinical trial (AFSSAPS 2005/04/003) at the French Ministry of Health.

 Study was supported by grants from French Ministry of Health (PHRC 2004 program hospitalier de recherche clinique).

PII: S0022-5347(10)03049-1

doi: 10.1016/j.juro.2010.03.054

The Journal of Urology
Volume 184, Issue 2 , Pages 696-701 , August 2010

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