The Journal of Urology
Volume 184, Issue 1 , Pages 26-33 , July 2010

Therapeutic Applications of Mesenchymal Stem Cells to Repair Kidney Injury

  • Hiroshi Asanuma

      Affiliations

    • Department of Urology, Indiana University School of Medicine, Indianapolis, Indiana
  • ,
  • Daniel R. Meldrum

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana
  • ,
  • Kirstan K. Meldrum

      Affiliations

    • Department of Urology, Indiana University School of Medicine, Indianapolis, Indiana
    • Corresponding Author InformationCorrespondence: Pediatric Urology, Riley Hospital for Children, 702 Barnhill Dr., Suite 4230, Indianapolis, Indiana 46202 (telephone: 317-278-8556; FAX: 317-274-7481)

Received 26 August 2009

References 

  1. Gilbertson DT, Liu J, Xue JL, et al. Projecting the number of patients with end-stage renal disease in the United States to the year 2015. J Am Soc Nephrol. 2005;16:3736
  2. Morigi M, Imberti B, Zoja C, et al. Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure. J Am Soc Nephrol. 2004;15:1794
  3. Weissman IL. Stem cells: units of development, units of regeneration, and units in evolution. Cell. 2000;100:157
  4. Jiang Y, Jahagirdar BN, Reinhardt RL, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 2002;418:41
  5. Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells (The International Society for Cellular Therapy position statement). Cytotherapy. 2006;8:315
  6. Schrijvers BF, Flyvbjerg A, De Vriese AS. The role of vascular endothelial growth factor (VEGF) in renal pathophysiology. Kidney Int. 2004;65:2003
  7. Kano MR, Morishita Y, Iwata C, et al. VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B-PDGFRbeta signaling. J Cell Sci. 2005;118:3759
  8. Rehman J, Traktuev D, Li J, et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation. 2004;109:1292
  9. Hirschberg R, Ding H. Mechanisms of insulin-like growth factor-I-induced accelerated recovery in experimental ischemic acute renal failure. Miner Electrolyte Metab. 1998;24:211
  10. Zeisberg M, Hanai J, Sugimoto H, et al. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med. 2003;9:964
  11. Crisostomo PR, Wang Y, Markel TA, et al. Human mesenchymal stem cells stimulated by TNF-alpha, LPS, or hypoxia produce growth factors by an NF kappa B- but not JNK-dependent mechanism. Am J Physiol Cell Physiol. 2008;294:C675
  12. Crisostomo PR, Wang M, Herring CM, et al. Sex dimorphisms in activated mesenchymal stem cell function. Shock. 2006;26:571
  13. Sato K, Ozaki K, Oh I, et al. Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood. 2007;109:228
  14. Herrera MB, Bussolati B, Bruno S, et al. Exogenous mesenchymal stem cells localize to the kidney by means of CD44 following acute tubular injury. Kidney Int. 2007;72:430
  15. Ninichuk V, Gross O, Segerer S, et al. Multipotent mesenchymal stem cells reduce interstitial fibrosis but do not delay progression of chronic kidney disease in collagen4A3-deficient mice. Kidney Int. 2006;70:121
  16. Wong CY, Cheong SK, Mok PL, et al. Differentiation of human mesenchymal stem cells into mesangial cells in post-glomerular injury murine model. Pathology. 2008;40:52
  17. Togel F, Isaac J, Hu Z, et al. Renal SDF-1 signals mobilization and homing of CXCR4-positive cells to the kidney after ischemic injury. Kidney Int. 2005;67:1772
  18. Bi B, Schmitt R, Israilova M, et al. Stromal cells protect against acute tubular injury via an endocrine effect. J Am Soc Nephrol. 2007;18:2486
  19. Yokoo T, Fukui A, Ohashi T, et al. Xenobiotic kidney organogenesis from human mesenchymal stem cells using a growing rodent embryo. J Am Soc Nephrol. 2006;17:1026
  20. Herrera MB, Bussolati B, Bruno S, et al. Mesenchymal stem cells contribute to the renal repair of acute tubular epithelial injury. Int J Mol Med. 2004;14:1035
  21. Tögel F, Hu Z, Weiss K, et al. Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. Am J Physiol Renal Physiol. 2005;289:F31
  22. Humphreys BD, Bonventre JV. Mesenchymal stem cells in acute kidney injury. Annu Rev Med. 2008;59:311
  23. Held PK, Al-Dhalimy M, Willenbring H, et al. In vivo genetic selection of renal proximal tubules. Mol Ther. 2006;13:49
  24. Colletti EJ, Airey JA, Liu W, et al. Generation of tissue-specific cells from MSC does not require fusion or donor-to-host mitochondrial/membrane transfer. Stem Cell Res. 2009;2:125
  25. Wang M, Tsai BM, Crisostomo PR, et al. Pretreatment with adult progenitor cells improves recovery and decreases native myocardial proinflammatory signaling after ischemia. Shock. 2006;25:454
  26. Wairiuko GM, Crisostomo PR, Wang M, et al. Stem cells improve right ventricular functional recovery after acute pressure overload and ischemia reperfusion injury. J Surg Res. 2007;141:241
  27. Ohnishi S, Yanagawa B, Tanaka K, et al. Transplantation of mesenchymal stem cells attenuates myocardial injury and dysfunction in a rat model of acute myocarditis. J Mol Cell Cardiol. 2007;42:88
  28. Crisostomo PR, Wang M, Markel TA, et al. Stem cell mechanisms and paracrine effects: potential in cardiac surgery. Shock. 2007;28:375
  29. Tögel F, Cohen A, Zhang P, et al. Autologous and allogeneic marrow stromal cells are safe and effective for the treatment of acute kidney injury. Stem Cells Dev. 2009;18:475
  30. Imberti B, Morigi M, Tomasoni S, et al. Insulin-like growth factor-1 sustains stem cell mediated renal repair. J Am Soc Nephrol. 2007;18:2921
  31. Kunter U, Rong S, Boor P, et al. Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes. J Am Soc Nephrol. 2007;18:1754
  32. Bussolati B, Tetta C, Camussi G. Contribution of stem cells to kidney repair. Am J Nephrol. 2008;28:813
  33. Lange C, Togel F, Ittrich H, et al. Administered mesenchymal stem cells enhance recovery from ischemia/reperfusion-induced acute renal failure in rats. Kidney Int. 2005;68:1613
  34. Morigi M, Introna M, Imberti B, et al. Human bone marrow mesenchymal stem cells accelerate recovery of acute renal injury and prolong survival in mice. Stem Cells. 2008;26:2075
  35. Behr L, Hekmati M, Lucchini A, et al. Evaluation of the effect of autologous mesenchymal stem cell injection in a large-animal model of bilateral kidney ischaemia reperfusion injury. Cell Prolif. 2009;42:284
  36. Sharma S, Gupta DK, Kumar L, et al. Are therapeutic stem cells justified in bilateral multicystic kidney disease? (A review of literature with insights into the embryology). Pediatr Surg Int. 2007;23:801
  37. Westenfelder C, Doty J, Horne B, et al. Administration of allogeneic mesenchymal stem cells in open heart surgery patients is safe and prevents post-operative AKI and CKD, and reduces length of stay and readmission rates: results of phase I trial. In: Presented at annual meeting of American Society of Nephrology. San Diego, California. October 27–November 1, 2009;
  38. Choi S, Park M, Kim J, et al. The role of mesenchymal stem cells in the functional improvement of the chronic renal failure. Stem Cells Dev. 2009;18:521
  39. Semedo P, Correa-Costa M, Cenedeze MA, et al. Mesenchymal stem cells attenuate renal fibrosis through immune modulation and remodeling properties in a rat remnant kidney model. Stem Cells. 2009;27:3063
  40. Ezquer FE, Ezquer ME, Parrau DB, et al. Systemic administration of multipotent mesenchymal stromal cells reverts hyperglycemia and prevents nephropathy in type 1 diabetic mice. Biol Blood Marrow Transplant. 2008;14:631
  41. Bani-Hani AH, Campbell MT, Meldrum DR, et al. Cytokines in epithelial-mesenchymal transition: a new insight into obstructive nephropathy. J Urol. 2008;180:461
  42. Asanuma H, Hile KL, Zhang H, et al. Arterially delivered mesenchymal stem cells prevent renal fibrosis. J Urol. 2009;181(suppl.):252;abstract 705
  43. Zhang W, Qin C, Zhou ZM. Mesenchymal stem cells modulate immune responses combined with cyclosporine in a rat renal transplantation model. Transplant Proc. 2007;39:3404
  44. Crop MJ, Baan CC, Korevaar SS, et al. Donor-derived mesenchymal stem cells suppress alloreactivity of kidney transplant patients. Transplantation. 2009;87:896
  45. Hu X, Yu SP, Fraser JL, et al. Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis. J Thorac Cardiovasc Surg. 2008;135:799
  46. Erwin GS, Crisostomo PR, Wang Y, et al. Estradiol-treated mesenchymal stem cells improve myocardial recovery after ischemia. J Surg Res. 2009;152:319
  47. Mias C, Trouche E, Seguelas MH, et al. Ex vivo pretreatment with melatonin improves survival, proangiogenic/mitogenic activity, and efficiency of mesenchymal stem cells injected into ischemic kidney. Stem Cells. 2008;26:1749
  48. Hagiwara M, Shen B, Chao L, et al. Kallikrein-modified mesenchymal stem cell implantation provides enhanced protection against acute ischemic kidney injury by inhibiting apoptosis and inflammation. Hum Gene Ther. 2008;19:807
  49. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663
  50. Tolar J, Nauta AJ, Osborn MJ, et al. Sarcoma derived from cultured mesenchymal stem cells. Stem Cells. 2007;25:371

 Study received animal care and use committee approval.

PII: S0022-5347(10)03045-4

doi: 10.1016/j.juro.2010.03.050

The Journal of Urology
Volume 184, Issue 1 , Pages 26-33 , July 2010