The Journal of Urology
Volume 184, Issue 1 , Pages 203-209 , July 2010

Circumcision and Reduced Risk of Self-Reported Penile Coital Injuries: Results From a Randomized Controlled Trial in Kisumu, Kenya

  • Supriya D. Mehta

      Affiliations

    • Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, Illinois
    • Corresponding Author InformationCorrespondence: 1603 W. Taylor St., M/C 923, Chicago, Illinois 60622 (telephone: 312-413-7485; FAX: 312-996-0064)
    • ,
  • John N. Krieger

      Affiliations

    • Department of Urology, University of Washington, Seattle, Washington
    • ,
  • Kawango Agot

      Affiliations

    • UNIM Project, Kisumu, Kenya
    • ,
  • Stephen Moses

      Affiliations

    • Departments of Medical Microbiology, Community Health Sciences and Medicine, University of Manitoba, Winnipeg, Canada
    • Recipient of a Canadian Institutes of Health Research Investigator Award.
    • ,
  • Jeckoniah O. Ndinya-Achola

      Affiliations

    • Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
    • ,
  • Corette Parker

      Affiliations

    • RTI International, Research Triangle Park, North Carolina
    • ,
  • Robert C. Bailey

      Affiliations

    • Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, Illinois

Received 27 October 2009

References 

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  2. Szabo R, Short RV. How does male circumcision protect against HIV infection?. BMJ. 2000;320:1592
  3. Koelle DM, Abbo H, Peck A, et al. Direct recovery of herpes simplex virus (HSV)-specific T lymphocyte clones from recurrent genital HSV-2 lesions. J Infect Dis. 1994;169:956
  4. Kaul R, Pettengell C, Sheth PM, et al. The genital tract immune milieu: an important determinant of HIV susceptibility and secondary transmission. J Reprod Immunol. 2008;77:32
  5. Fleming DT, Wasserheit JN. From epidemiological synergy to public health policy and practice: the contribution of other sexually transmitted diseases to sexual transmission of HIV infection. Sex Transm Infect. 1999;75:3
  6. McCoombe SG, Short RV. Potential HIV-1 target cells in the human penis. AIDS. 2006;20:1491
  7. Cerone JS, Agarwal P, McAchran S, et al. Penile fracture with isolated corpus spongiosum injury. Int J Impot Res. 2006;18:218
  8. Cumming J, Jenkins JD. Fracture of the corpora cavernosa and urethral rupture during sexual intercourse. Br J Urol. 1991;67:327
  9. De Rose AF, Giglio M, Carmignani G. Traumatic rupture of the corpora cavernosa: new physiopathologic acquisitions. Urology. 2001;57:319
  10. El Atat R, Sfaxi M, Benslama MR, et al. Fracture of the penis: management and long-term results of surgical treatment (Experience in 300 cases). J Trauma. 2008;64:121
  11. Kamdar C, Mooppan UM, Kim H, et al. Penile fracture: preoperative evaluation and surgical technique for optimal patient outcome. BJU Int. 2008;102:1640
  12. Maruschke M, Lehr C, Hakenberg OW. Traumatic penile injuries–mechanisms and treatment. Urol Int. 2008;81:367
  13. Cheng YS, Lin JS, Lin YM. Isolated posterior urethral injury: an unusual complication and presentation following male coital trauma. Asian J Androl. 2006;8:379
  14. Mehta SD, Moses S, Agot K, et al. Adult male circumcision does not reduce the risk of incident Neisseria gonorrhoeae, Chlamydia trachomatis, or Trichomonas vaginalis infection: results from a randomized, controlled trial in Kenya. J Infect Dis. 2009;200:370
  15. Bailey RC, Moses S, Parker CB, et al. Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial. Lancet. 2007;369:643
  16. Holm S. A simple sequentially rejective multiple test procedure. Scand J Statist. 1979;6:65
  17. Bailey RC, Neema S, Othieno R. Sexual behaviors and other HIV risk factors in circumcised and uncircumcised men in Uganda. J Acquir Immune Defic Syndr. 1999;22:294
  18. Kalichman SC, Simbayi LC, Cain D, et al. Coital bleeding and HIV risks among men and women in Cape Town, South Africa. Sex Transm Dis. 2006;33:551
  19. Figueroa JP, Brathwaite A, Morris J, et al. Rising HIV-1 prevalence among sexually transmitted disease clinic attenders in Jamaica: traumatic sex and genital ulcers as risk factors. J Acquir Immune Defic Syndr. 1994;7:310
  20. Wald A, Link K. Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis. J Infect Dis. 2002;185:45
  21. Freeman EE, Weiss HA, Glynn JR, et al. Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies. AIDS. 2006;20:73
  22. Celum C, Levine R, Weaver M, et al. Genital herpes and human immunodeficiency virus: double trouble. Bull World Health Organ. 2004;82:447
  23. Buechner SA. Common skin disorders of the penis. BJU Int. 2002;90:498
  24. Eke N. Urological complications of coitus. BJU Int. 2002;89:273
  25. Hoffman RJ, Ganti S. Vaginal laceration and perforation resulting from first coitus. Pediatr Emerg Care. 2001;17:113
  26. Anate M. Vaginal trauma at sexual intercourse in Ilorin, Nigeria (An analysis of 36 cases). West Afr J Med. 1989;8:217
  27. Brown JE, Ayowa OB, Brown RC. Dry and tight: sexual practices and potential AIDS risk in Zaire. Soc Sci Med. 1993;37:989

 Study received institutional review board approval.

 Supported by Grant AI50440 from the Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, and by Grant HCT 44180 from the Canadian Institutes of Health Research. The sponsors reviewed and commented on the study design, and monitored the study management and analyses. The sponsors had no role in the final analyses, interpretation of the data, or in the preparation, review or approval of the manuscript.

PII: S0022-5347(10)02988-5

doi: 10.1016/j.juro.2010.03.015

The Journal of Urology
Volume 184, Issue 1 , Pages 203-209 , July 2010

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