The Journal of Urology
Volume 183, Issue 6 , Pages 2419-2423 , June 2010

Citrate, Malate and Alkali Content in Commonly Consumed Diet Sodas: Implications for Nephrolithiasis Treatment

  • Brian H. Eisner

      Affiliations

    • Department of Urology, University of California-San Francisco, San Francisco, California
    • Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
    • Corresponding Author InformationCorrespondence: Department of Urology, GRB 1102, Massachusetts General Hospital, 55 Fruit St., Boston, Massachusetts 02114 (telephone: 617-726-3512; FAX: 617-726-6131)
    • Financial interest and/or other relationship with Boston Scientific, PercSys and Ravine Group.
    • ,
  • John R. Asplin

      Affiliations

    • Litholink Corp., Chicago, Illinois, and Nephrology Section, New York Harbor Veterans Affairs Medical Center, New York, New York
    • Financial interest and/or other relationship with Ravine Group.
    • ,
  • David S. Goldfarb

      Affiliations

    • Department of Urology, St. Vincent's Hospital and New York University School of Medicine, New York, New York
    • Financial interest and/or other relationship with Ravine Group.
    • ,
  • Ardalanejaz Ahmad

      Affiliations

    • Department of Urology, University of California-San Francisco, San Francisco, California
    • ,
  • Marshall L. Stoller

      Affiliations

    • Department of Urology, University of California-San Francisco, San Francisco, California
    • Financial interest and/or other relationship with PercSys and Ravine Group.

Received 11 September 2009

References 

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  2. Nicar MJ, Skurla C, Sakhaee K, et al. Low urinary citrate excretion in nephrolithiasis. Urology. 1983;21:8
  3. Rudman D, Kutner MH, Redd SC, et al. Hypocitraturia in calcium nephrolithiasis. J Clin Endocrinol Metab. 1982;55:1052
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  8. Seltzer MA, Low RK, McDonald M, et al. Dietary manipulation with lemonade to treat hypocitraturic calcium nephrolithiasis. J Urol. 1996;156:907
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  11. Sakhaee K, Alpern R, Poindexter J, et al. Citraturic response to oral citric acid load. J Urol. 1992;147:975
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  14. Aras B, Kalfazade N, Tugcu V, et al. Can lemon juice be an alternative to potassium citrate in the treatment of urinary calcium stones in patients with hypocitraturia? (A prospective randomized study). Urol Res. 2008;36:313
  15. Kang DE, Sur RL, Haleblian GE, et al. Long-term lemonade based dietary manipulation in patients with hypocitraturic nephrolithiasis. J Urol. 2007;177:1358
  16. Koff SG, Paquette EL, Cullen J, et al. Comparison between lemonade and potassium citrate and impact on urine pH and 24-hour urine parameters in patients with kidney stone formation. Urology. 2007;69:1013
  17. Penniston KL, Steele TH, Nakada SY. Lemonade therapy increases urinary citrate and urine volumes in patients with recurrent calcium oxalate stone formation. Urology. 2007;70:856
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  19. Taylor EN, Curhan GC. Fructose consumption and the risk of kidney stones. Kidney Int. 2008;73:207
  20. Goodman JW, Asplin JR, Goldfarb DS. Effect of two sports drinks on urinary lithogenicity. Urol Res. 2009;37:41
  21. Goldfarb DS, Fischer ME, Keich Y, et al. A twin study of genetic and dietary influences on nephrolithiasis: a report from the Vietnam Era Twin (VET) Registry. Kidney Int. 2005;67:1053
  22. Penniston KL, Nakada SY, Holmes RP, et al. Quantitative assessment of citric acid in lemon juice, lime juice, and commercially-available fruit juice products. J Endourol. 2008;22:567
  23. Haleblian GE, Leitao VA, Pierre SA, et al. Assessment of citrate concentrations in citrus fruit-based juices and beverages: implications for management of hypocitraturic nephrolithiasis. J Endourol. 2008;22:1359
  24. Odvina CV. Comparative value of orange juice versus lemonade in reducing stone-forming risk. Clin J Am Soc Nephrol. 2006;1:1269
  25. Passman CM, Holmes RP, Knight J, et al. Effect of soda consumption on urinary stone risk parameters. J Endourol. 2009;23:347
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 Study received institutional review board approval.

 Supplementary material for this article can be obtained at www.massgeneral.org/journalofurology.

PII: S0022-5347(10)02656-X

doi: 10.1016/j.juro.2010.02.2388

The Journal of Urology
Volume 183, Issue 6 , Pages 2419-2423 , June 2010

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