The Journal of Urology
Volume 184, Issue 1 , Pages 286-291 , July 2010

The Swedish Reflux Trial in Children: III. Urinary Tract Infection Pattern

  • Per Brandström

      Affiliations

    • Pediatric Uro-Nephrologic Center, Queen Silvia Children's Hospital, University of Gothenburg, Göteborg, Sweden
  • ,
  • Elisabeth Esbjörner

      Affiliations

    • Department of Pediatrics, Örebro University Hospital, Örebro, Sweden
  • ,
  • Maria Herthelius

      Affiliations

    • Department of Clinical Science, Intervention and Technology, Division of Pediatrics, Karolinska University Hospital, Huddinge, Sweden
  • ,
  • Svante Swerkersson

      Affiliations

    • Pediatric Uro-Nephrologic Center, Queen Silvia Children's Hospital, University of Gothenburg, Göteborg, Sweden
  • ,
  • Ulf Jodal

      Affiliations

    • Pediatric Uro-Nephrologic Center, Queen Silvia Children's Hospital, University of Gothenburg, Göteborg, Sweden
  • ,
  • Sverker Hansson

      Affiliations

    • Pediatric Uro-Nephrologic Center, Queen Silvia Children's Hospital, University of Gothenburg, Göteborg, Sweden
    • Corresponding Author InformationCorrespondence: Pediatric Uro-Nephrologic Center, Queen Silvia Children's Hospital, SE-416 85 Göteborg, Sweden

Received 30 September 2009

References 

  1. Swerkersson S, Jodal U, Sixt R, et al. Relationship among vesicoureteral reflux, urinary tract infection and renal damage in children. J Urol. 2007;178:647
  2. Montini G, Zucchetta P, Tomasi L, et al. Value of imaging studies after a first febrile urinary tract infection in young children: data from Italian renal infection study 1. Pediatrics. 2009;123:e239
  3. Jodal U, Smellie JM, Lax H, et al. Ten-year results of randomized treatment of children with severe vesicoureteral reflux (Final report of the International Reflux Study in Children). Pediatr Nephrol. 2006;21:785
  4. Prospective trial of operative versus non-operative treatment of severe vesicoureteric reflux in children: five years' observation (Birmingham Reflux Study Group). Br Med J (Clin Res Ed). 1987;295:237
  5. Läckgren G, Wåhlin N, Stenberg A. Endoscopic treatment of children with vesico-ureteric reflux. Acta Paediatr. 1999;88(suppl.):62
  6. Kirsch AJ, Perez-Brayfield MR, Scherz HC. Minimally invasive treatment of vesicoureteral reflux with endoscopic injection of dextranomer/hyaluronic acid copolymer: the Children's Hospitals of Atlanta experience. J Urol. 2003;170:211
  7. Capozza N, Lais A, Nappo S, et al. The role of endoscopic treatment of vesicoureteral reflux: a 17-year experience. J Urol. 2004;172:1626
  8. Puri P, Pirker M, Mohanan N, et al. Subureteral dextranomer/hyaluronic acid injection as first line treatment in the management of high grade vesicoureteral reflux. J Urol. 2006;176:1856
  9. Stenberg A, Hensle TW, Läckgren G. Vesicoureteral reflux: a new treatment algorithm. Curr Urol Rep. 2002;3:107
  10. Elder JS, Shah MB, Batiste LR, et al. Part 3: endoscopic injection versus antibiotic prophylaxis in the reduction of urinary tract infections in patients with vesicoureteral reflux. Curr Med Res Opin. 2007;23(suppl.):S15
  11. Stenberg A, Läckgren G. Treatment of vesicoureteral reflux in children using stabilized non-animal hyaluronic acid/dextranomer gel (NASHA/DX): a long-term observational study. J Pediatr Urol. 2007;3:80
  12. Elmore JM, Kirsch AJ, Heiss EA, et al. Incidence of urinary tract infections in children after successful ureteral reimplantation versus endoscopic dextranomer/hyaluronic acid implantation. J Urol. 2008;179:2364
  13. Chi A, Gupta A, Snodgrass W. Urinary tract infection following successful dextranomer/hyaluronic acid injection for vesicoureteral reflux. J Urol. 2008;179:1966
  14. Sedberry-Ross S, Rice DC, Pohl HG, et al. Febrile urinary tract infections in children with an early negative voiding cystourethrogram after treatment of vesicoureteral reflux with dextranomer/hyaluronic acid. J Urol. 2008;180:1605
  15. Le Saux N, Pham B, Moher D. Evaluating the benefits of antimicrobial prophylaxis to prevent urinary tract infections in children: a systematic review. CMAJ. 2000;163:523
  16. Williams GJ, Wei L, Lee A, et al. Long-term antibiotics for preventing recurrent urinary tract infection in children. Cochrane Database Syst Rev. 2006;3:CD001534
  17. Brandström P, Esbjörner E, Herthelius M, et al. The Swedish Reflux Trial in Children: I. Study design and study population characteristics. J Urol. 2010;184:274
  18. Pocock SJ, Simon R. Sequential treatment assignment with balancing for prognostic factors in the controlled clinical trial. Biometrics. 1975;31:103
  19. Holmdahl G, Brandström P, Läckgren G, et al. The Swedish Reflux Trial in Children: II. Vesicoureteral reflux outcome. J Urol. 2010;184:280
  20. Brandström P, Nevéus T, Sixt R, et al. The Swedish Reflux Trial in Children: IV. Renal damage. J Urol. 2010;184:292
  21. Winberg J, Andersen HJ, Bergström T, et al. Epidemiology of symptomatic urinary tract infection in childhood. Acta Paediatr Scand. 1974;252(suppl.):1
  22. Jodal U, Winberg J. Management of children with unobstructed urinary tract infection. Pediatr Nephrol. 1987;1:647
  23. Hanson E, Hansson S, Jodal U. Trimethoprim-sulphadiazine prophylaxis in children with vesico-ureteric reflux. Scand J Infect Dis. 1989;21:201
  24. Conway PH, Cnaan A, Zaoutis T, et al. Recurrent urinary tract infections in children: risk factors and association with prophylactic antimicrobials. JAMA. 2007;298:179
  25. Wheeler D, Vimalachandra D, Hodson EM, et al. Antibiotics and surgery for vesicoureteric reflux: a meta-analysis of randomised controlled trials. Arch Dis Child. 2003;88:688
  26. Garin EH, Olavarria F, Garcia Nieto V, et al. Clinical significance of primary vesicoureteral reflux and urinary antibiotic prophylaxis after acute pyelonephritis: a multicenter, randomized, controlled study. Pediatrics. 2006;117:626
  27. Roussey-Kesler G, Gadjos V, Idres N, et al. Antibiotic prophylaxis for the prevention of recurrent urinary tract infection in children with low grade vesicoureteral reflux: results from a prospective randomized study. J Urol. 2008;179:674
  28. Pennesi M, Travan L, Peratoner L, et al. Is antibiotic prophylaxis in children with vesicoureteral reflux effective in preventing pyelonephritis and renal scars? (A randomized, controlled trial). Pediatrics. 2008;121:e1489
  29. Montini G, Rigon L, Zucchetta P, et al. Prophylaxis after first febrile urinary tract infection in children? (A multicenter, randomized, controlled, noninferiority trial). Pediatrics. 2008;122:1064
  30. Keren R, Carpenter MA, Hoberman A, et al. Rationale and design issues of the Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR) study. Pediatrics. 2008;122(suppl.):S240

 Study received approval from research ethics committees at participating centers.

 Supported by grants from the West Region, Sweden and Futurum, Jönköping County Council, Sweden.

PII: S0022-5347(10)00153-9

doi: 10.1016/j.juro.2010.01.061

The Journal of Urology
Volume 184, Issue 1 , Pages 286-291 , July 2010