The Journal of Urology
Volume 184, Issue 1 , Pages 292-297 , July 2010

The Swedish Reflux Trial in Children: IV. Renal Damage

  • Per Brandström

      Affiliations

    • Pediatric Uro-Nephrologic Center, The Queen Silvia Children's Hospital, University of Gothenburg, Göteborg, Sweden
    • ,
  • Tryggve Nevéus

      Affiliations

    • Department of Pediatrics, Uppsala University Children's Hospital, Uppsala, Sweden
    • ,
  • Rune Sixt

      Affiliations

    • Pediatric Uro-Nephrologic Center, The Queen Silvia Children's Hospital, University of Gothenburg, Göteborg, Sweden
    • ,
  • Eira Stokland

      Affiliations

    • Pediatric Uro-Nephrologic Center, The Queen Silvia Children's Hospital, University of Gothenburg, Göteborg, Sweden
    • ,
  • Ulf Jodal

      Affiliations

    • Pediatric Uro-Nephrologic Center, The Queen Silvia Children's Hospital, University of Gothenburg, Göteborg, Sweden
    • ,
  • Sverker Hansson

      Affiliations

    • Pediatric Uro-Nephrologic Center, The Queen Silvia Children's Hospital, University of Gothenburg, Göteborg, Sweden
    • Corresponding Author InformationCorrespondence: Pediatric Uro-Nephrologic Center, Queen Silvia Children's Hospital, SE-416 85 Göteborg, Sweden

Received 30 September 2009

References 

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  2. Bailey RR. The relationship of vesico-ureteric reflux to urinary tract infection and chronic pyelonephritis-reflux nephropathy. Clin Nephrol. 1973;1:132
  3. Rushton HG, Majd M, Jantausch B, et al. Renal scarring following reflux and nonreflux pyelonephritis in children: evaluation with 99mtechnetium-dimercaptosuccinic acid scintigraphy. J Urol. 1992;147:1327
  4. Jakobsson B, Berg U, Svensson L. Renal scarring after acute pyelonephritis. Arch Dis Child. 1994;70:111
  5. Stokland E, Hellström M, Jacobsson B, et al. Renal damage one year after first urinary tract infection: role of dimercaptosuccinic acid scintigraphy. J Pediatr. 1996;129:815
  6. Preda I, Jodal U, Sixt R, et al. Normal dimercaptosuccinic acid scintigraphy makes voiding cystourethrography unnecessary after urinary tract infection. J Pediatr. 2007;151:581
  7. Goldman M, Bistritzer T, Horne T, et al. The etiology of renal scars in infants with pyelonephritis and vesicoureteral reflux. Pediatr Nephrol. 2000;14:385
  8. Wennerström M, Hansson S, Jodal U, et al. Primary and acquired renal scarring in boys and girls with urinary tract infection. J Pediatr. 2000;136:30
  9. Craig JC, Irwig LM, Knight JF, et al. Does treatment of vesicoureteric reflux in childhood prevent end-stage renal disease attributable to reflux nephropathy?. Pediatrics. 2000;105:1236
  10. Fanos V, Cataldi L. Antibiotics or surgery for vesicoureteric reflux in children. Lancet. 2004;364:1720
  11. Brandström P, Esbjörner E, Herthelius M, et al. The Swedish Reflux Trial in Children: I. Study design and study population characteristics. J Urol. 2010;184:274
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  13. Lebowitz RL, Olbing H, Parkkulainen KV, et al. International system of radiographic grading of vesicoureteric reflux (International Reflux Study in Children). Pediatr Radiol. 1985;15:105
  14. Piepsz A, Colarinha P, Gordon I, et al. Guidelines on 99mTc-DMSA scintigraphy in children. Eur J Nucl Med. 2001;28:37
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  17. Brandström P, Esbjörner E, Herthelius M, et al. The Swedish Reflux Trial in Children: III. Urinary tract infection pattern. J Urol. 2010;184:286
  18. Winberg J, Andersen HJ, Bergström T, et al. Epidemiology of symptomatic urinary tract infection in childhood. Acta Paediatr Scand. 1974;252(suppl.):1
  19. Hansson S, Bollgren I, Esbjörner E, et al. Urinary tract infections in children below two years of age: a quality assurance project in Sweden (The Swedish Pediatric Nephrology Association). Acta Paediatr. 1999;88:270
  20. Garin EH, Olavarria F, Garcia Nieto V, et al. Clinical significance of primary vesicoureteral reflux and urinary antibiotic prophylaxis after acute pyelonephritis: a multicenter, randomized, controlled study. Pediatrics. 2006;117:626
  21. Pennesi M, Travan L, Peratoner L, et al. Is antibiotic prophylaxis in children with vesicoureteral reflux effective in preventing pyelonephritis and renal scars? (A randomized, controlled trial). Pediatrics. 2008;121:e1489
  22. Montini G, Rigon L, Zucchetta P, et al. Prophylaxis after first febrile urinary tract infection in children? (A multicenter, randomized, controlled, noninferiority trial). Pediatrics. 2008;122:1064
  23. Keren R, Carpenter MA, Hoberman A, et al. Rationale and design issues of the Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR) study. Pediatrics. 2008;122(suppl.):S240

 Supplementary material for this article can be obtained at http://hdl.handle.net/2077/22171.

 Study received approval from research ethics committees at participating centers.

 Supported by grants from the West Region, Sweden and Futurum, Jönköping County Council, Sweden.

PII: S0022-5347(10)00147-3

doi: 10.1016/j.juro.2010.01.060

The Journal of Urology
Volume 184, Issue 1 , Pages 292-297 , July 2010

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