The Journal of Urology
Volume 183, Issue 4 , Pages 1444-1449 , April 2010

Durability of Urethral Bulking Agent Injection for Female Stress Urinary Incontinence: 2-Year Multicenter Study Results

  • Gamal Ghoniem

      Affiliations

    • Cleveland Clinic Florida, Weston, Florida
    • Corresponding Author InformationCorrespondence: Section of Voiding Dysfunction, Female Urology and Reconstruction, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd., Weston, Florida 33331-3609 (telephone: 954-659-5188; FAX: 954-659-5189)
    • Financial interest and/or other relationship with Astellas, Uroplasty and Coloplast.
    • ,
  • Jacques Corcos

      Affiliations

    • McGill Urology Associates, Montreal, Quebec, Canada
    • Financial interest and/or other relationship with Johnson & Johnson and Astellas.
    • ,
  • Craig Comiter

      Affiliations

    • University of Arizona, Tucson, Arizona
    • Financial interest and/or other relationship with Coloplast, Pfizer, Astellas and Johnson & Johnson.
    • ,
  • O. Lenaine Westney

      Affiliations

    • University of Texas, Houston, Texas
    • Financial interest and/or other relationship with American Medical Systems and Coloplast.
    • ,
  • Sender Herschorn

      Affiliations

    • University of Toronto, Toronto, Canada
    • Financial interest and/or other relationship with Johnson & Johnson and Coloplast.

Received 14 September 2009

References 

  1. Fultz NH, Burgio K, Diokno AC, et al. Burden of stress urinary incontinence for community-dwelling women. Am J Obstet Gynecol. 2003;189:1275
  2. Robinson D, Anders K, Cardozo L, et al. What women want—their interpretation of the concept of cure. Neurourol Urodyn. 2002;21:429
  3. Langford CF, Elmissiry MM, Ghoniem GM. Do women have realistic expectations of treatment for stress urinary incontinence?. Neurourol Urodyn. 2008;27:480
  4. Murless BC. The injection treatment of stress incontinence. J Obstet Gynaecol Br Emp. 1938;45:67
  5. Appell RA, Winters JC. Periurethral bulking agents. Urogynecology and Urodynamics. Philadelphia: Williams&Wilkins; 1996;
  6. Olson ME, Morck DW, Ceri H, et al. Evaluation of autologous fat implantation in the rat urinary bladder submucosa. Urology. 1998;52:915
  7. Lightner D, Calvosa C, Andersen R, et al. A new injectable bulking agent for treatment of stress urinary incontinence: results of a multicenter, randomized, controlled double-blind study of Durasphere. Urology. 2001;58:12
  8. Chrouser KL, Fick F, Goel A, et al. Carbon coated zirconium beads in β-glucan gel and bovine glutaraldehyde cross-linked collagen injections for intrinsic sphincter deficiency: continence and satisfaction after extended followup. J Urol. 2004;171:1152
  9. Gorton E, Stanton S, Monga A, et al. Periurethral collagen injection: a long-term follow-up study. BJU Intl. 1999;84:966
  10. Herschorn S, Radomski DB, Steele DJ. Early experience with intraurethral collage injections for urinary incontinence. J Urol. 1992;148:1797
  11. Beisang AA, Ersek RA. Mammalian response to subdermal implantation of textured microimplants. Aesth Plast Surg. 1992;16:83
  12. Herschorn S. Current status of injectable agents for female stress urinary incontinence. Can J Urol. 2001;8:1281
  13. Radley SC, Chapple CR, Lee JA. Transurethral implantation of silicone polymer for stress incontinence evaluation of porcine model and mechanism of action in vivo. BJU Int. 2000;85:646
  14. Tamanini JT, D'Ancona CAL, Tadini V, et al. Macroplastique implantation system for the treatment of female stress urinary incontinence. J Urol. 2003;169:2229
  15. Soliman S, Evans C. Endoscopic Macroplastique™ injection for the treatment of female stress incontinence: role and efficacy. Afr J Urol. 2001;7:45
  16. Ghoniem G, Corcos J, Comiter C, et al. Cross-linked polydimethylsiloxane injection for female stress urinary incontinence: results of a multicenter, randomized, controlled, single-blind study. J Urol. 2009;181:204
  17. Harriss DR, Iacovou JW, Lemberger RJ. Peri-urethral silicone micro-implants (Macroplastique™) for the treatment of genuine stress incontinence. Br J Urol. 1996;78:722
  18. Mourad SM. Long-term efficacy of Macroplastique injection for the treatment of urinary incontinence in males and females. Afr J Urol. 2003;9:80
  19. Peeker R, Edlund C, Wennberg AL, et al. The treatment of sphincter incontinence with periurethral silicone implants (Macroplastique). Scand J Urol Nephrol. 2002;36:194
  20. Taminini JTN, D'Ancona CAL, Netto NR. Macroplastique implantation system for female stress urinary incontinence: long-term follow up. J Endourol. 2006;20:1082
  21. Coaptite Summary of Safety and Effectiveness (PMA No. P040047) (United States Food and Drug Administration). http://www.accessdata.fda.gov/cdrh_docs/pdf4/P040047b.pdfAccessed July 6, 2009
  22. Tschopp PJ, Wesley-James T, Spekkens A, et al. Collagen injections for urinary stress incontinence in a small urban urology practice: time to failure analysis of 99 cases. J Urol. 1999;162:779
  23. Hurtado E, McCrery R, Appell R. The safety and efficacy of ethylene vinyl alcohol copolymer as an intra-urethral bulking agent in women with intrinsic urethral deficiency. Int Urogynecol J Pelvic Floor Dysfunct. 2007;18:869
  24. Radley SC, Chapple CR, Mitsogiannis AC, et al. Transurethral implantation of Macroplastique® for the treatment of female stress urinary incontinence secondary to urethral sphincter deficiency. Eur Urol. 2001;39:383

 Study received institutional review board approval.

PII: S0022-5347(09)03202-9

doi: 10.1016/j.juro.2009.12.038

The Journal of Urology
Volume 183, Issue 4 , Pages 1444-1449 , April 2010

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