The Journal of Urology
Volume 183, Issue 3 , Pages 878-883 , March 2010

Renal Cell Carcinoma Fuhrman Grade and Histological Subtype Correlate With Complete Polymorphic Deletion of Glutathione S-Transferase M1 Gene

  • Michela De Martino

      Affiliations

    • Ludwig Boltzmann Cluster of Urology, Medical University of Vienna and Ludwig Boltzmann Cluster of Urology, Vienna, Austria
    • Equal study contribution.
    • ,
  • Tobias Klatte

      Affiliations

    • Department of Urology, Medical University of Vienna and Ludwig Boltzmann Cluster of Urology, Vienna, Austria
    • Equal study contribution.
    • Corresponding Author InformationCorrespondence: Department of Urology, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria (telephone: +43-1-40400-2616; FAX: +43-1-40400-2332)
    • ,
  • Georg Schatzl

      Affiliations

    • Department of Urology, Medical University of Vienna and Ludwig Boltzmann Cluster of Urology, Vienna, Austria
    • ,
  • Mesut Remzi

      Affiliations

    • Department of Urology, Medical University of Vienna and Ludwig Boltzmann Cluster of Urology, Vienna, Austria
    • ,
  • Matthias Waldert

      Affiliations

    • Department of Urology, Medical University of Vienna and Ludwig Boltzmann Cluster of Urology, Vienna, Austria
    • ,
  • Andrea Haitel

      Affiliations

    • Department of Pathology, Medical University of Vienna and Ludwig Boltzmann Cluster of Urology, Vienna, Austria
    • ,
  • Igor Stancik

      Affiliations

    • Department of Urology, Hietzing Hospital, Vienna, Austria
    • ,
  • Gero Kramer

      Affiliations

    • Ludwig Boltzmann Cluster of Urology, Medical University of Vienna and Ludwig Boltzmann Cluster of Urology, Vienna, Austria
    • Department of Urology, Medical University of Vienna and Ludwig Boltzmann Cluster of Urology, Vienna, Austria
    • ,
  • Michael Marberger

      Affiliations

    • Department of Urology, Medical University of Vienna and Ludwig Boltzmann Cluster of Urology, Vienna, Austria

Received 30 June 2009

References 

  1. Klatte T, Pantuck AJ. Molecular biology of renal cortical tumors. Urol Clin North Am. 2008;35:573
  2. Benichou J, Chow WH, McLaughlin JK, et al. Population attributable risk of renal cell cancer in Minnesota. Am J Epidemiol. 1998;148:424
  3. Buzio L, De PG, Mozzoni P, et al. Glutathione S-transferases M1-1 and T1-1 as risk modifiers for renal cell cancer associated with occupational exposure to chemicals. Occup Environ Med. 2003;60:789
  4. Karami S, Boffetta P, Rothman N, et al. Renal cell carcinoma, occupational pesticide exposure and modification by glutathione S-transferase polymorphisms. Carcinogenesis. 2008;29:1567
  5. Sweeney C, Farrow DC, Schwartz SM, et al. Glutathione S-transferase M1, T1, and P1 polymorphisms as risk factors for renal cell carcinoma: a case-control study. Cancer Epidemiol Biomarkers Prev. 2000;9:449
  6. McIlwain CC, Townsend DM, Tew KD. Glutathione S-transferase polymorphisms: cancer incidence and therapy. Oncogene. 2006;25:1639
  7. Cho SG, Lee YH, Park HS, et al. Glutathione S-transferase mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1. J Biol Chem. 2001;276:12749
  8. Smits KM, Schouten LJ, van Dijk BA, et al. Polymorphisms in genes related to activation or detoxification of carcinogens might interact with smoking to increase renal cancer risk: results from The Netherlands Cohort Study on diet and cancer. World J Urol. 2008;26:103
  9. Karagas MR, Park S, Warren A, et al. Gender, smoking, glutathione-S-transferase variants and bladder cancer incidence: a population-based study. Cancer Lett. 2005;219:63
  10. Longuemaux S, Delomenie C, Gallou C, et al. Candidate genetic modifiers of individual susceptibility to renal cell carcinoma: a study of polymorphic human xenobiotic-metabolizing enzymes. Cancer Res. 1999;59:2903
  11. Rebbeck TR. Molecular epidemiology of the human glutathione S-transferase genotypes GSTM1 and GSTT1 in cancer susceptibility. Cancer Epidemiol Biomarkers Prev. 1997;6:733
  12. Strange RC, Lear JT, Fryer AA. Glutathione S-transferase polymorphisms: influence on susceptibility to cancer. Chem Biol Interact, 111-. 1998;112:351
  13. Strange RC, Fryer AA. The glutathione S-transferases: influence of polymorphism on cancer susceptibility. IARC Sci Publ. 1999;231
  14. Howells RE, Holland T, Dhar KK, et al. Glutathione S-transferase GSTM1 and GSTT1 genotypes in ovarian cancer: association with p53 expression and survival. Int J Gynecol Cancer. 2001;11:107
  15. Howells RE, Redman CW, Dhar KK, et al. Association of glutathione S-transferase GSTM1 and GSTT1 null genotypes with clinical outcome in epithelial ovarian cancer. Clin Cancer Res. 1998;4:2439
  16. Davies SM, Robison LL, Buckley JD, et al. Glutathione S-transferase polymorphisms and outcome of chemotherapy in childhood acute myeloid leukemia. J Clin Oncol. 2001;19:1279
  17. Eble JN, Togashi K, Pisani P. Tumours of the kidney. In:  Eble JN,  Sauter G,  Epstein JI, et al. editor. World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. Lyon: IARC Press; 2004;p. 9–87chapt 1
  18. Kidney. In: AJCC Cancer Staging Manual. 6th ed.. New York: Springer; 2002;p. 323–325American Joint Committee on Cancer
  19. Fuhrman SA, Lasky LC, Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol. 1982;6:655
  20. Rowe JD, Nieves E, Listowsky I. Subunit diversity and tissue distribution of human glutathione S-transferases: interpretations based on electrospray ionization-MS and peptide sequence-specific antisera. Biochem J. 1997;325:481
  21. Rodilla V, Benzie AA, Veitch JM, et al. Glutathione S-transferases in human renal cortex and neoplastic tissue: enzymatic activity, isoenzyme profile and immunohistochemical localization. Xenobiotica. 1998;28:443
  22. Bruning T, Lammert M, Kempkes M, et al. Influence of polymorphisms of GSTM1 and GSTT1 for risk of renal cell cancer in workers with long-term high occupational exposure to trichloroethene. Arch Toxicol. 1997;71:596
  23. Dorion S, Lambert H, Landry J. Activation of the p38 signaling pathway by heat shock involves the dissociation of glutathione S-transferase Mu from Ask1. J Biol Chem. 2002;277:30792
  24. Ambrosone CB, Sweeney C, Coles BF, et al. Polymorphisms in glutathione S-transferases (GSTM1 and GSTT1) and survival after treatment for breast cancer. Cancer Res. 2001;61:7130
  25. Sweeney C, Nazar-Stewart V, Stapleton PL, et al. Glutathione S-transferase M1, T1, and P1 polymorphisms and survival among lung cancer patients. Cancer Epidemiol Biomarkers Prev. 2003;12:527
  26. Chenevix-Trench G, Young J, Coggan M, et al. Glutathione S-transferase M1 and T1 polymorphisms: susceptibility to colon cancer and age of onset. Carcinogenesis. 1995;16:1655
  27. Nascimento H, Coy CS, Teori MT, et al. Possible influence of glutathione S-transferase GSTT1 null genotype on age of onset of sporadic colorectal adenocarcinoma. Dis Colon Rectum. 2003;46:510
  28. Taioli E, Gaspari L, Benhamou S, et al. Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years. Int J Epidemiol. 2003;32:60
  29. Jung EJ, Lee HJ, Kwak C, et al. Young age is independent prognostic factor for cancer-specific survival of low-stage clear cell renal cell carcinoma. Urology. 2009;73:137
  30. Scoll BJ, Wong YN, Egleston BL, et al. Age, tumor size and relative survival of patients with localized renal cell carcinoma: a surveillance, epidemiology and end results analysis. J Urol. 2009;181:506

 Study received local ethics committee approval.

PII: S0022-5347(09)02921-8

doi: 10.1016/j.juro.2009.11.032

The Journal of Urology
Volume 183, Issue 3 , Pages 878-883 , March 2010

Article Tools

* Image Usage & Resolution