The Journal of Urology
Volume 183, Issue 2 , Pages 793-800 , February 2010

Role of TREK-1 Potassium Channel in Bladder Overactivity After Partial Bladder Outlet Obstruction in Mouse

Received 18 May 2009

References 

  1. Andersson KE, Arner A. Urinary bladder contraction and relaxation: physiology and pathophysiology. Physiol Rev. 2004;84:935
  2. Mostwin JL. Pathophysiology: the varieties of bladder overactivity. Urology. 2002;60:22
  3. O'Leary MP. Lower urinary tract symptoms/benign prostatic hyperplasia: maintaining symptom control and reducing complications. Urology. 2003;62:15
  4. Stein R, Gong C, Hutcheson JC, et al. The decompensated detrusor III: impact of bladder outlet obstruction on sarcoplasmic endoplasmic reticulum protein and gene expression. J Urol. 2000;164:1026
  5. Buttyan R, Chen MW, Levin RM. Animal models of bladder outlet obstruction and molecular insights into the basis for the development of bladder dysfunction. Eur Urol. 1997;32(suppl.):32
  6. Saito M, Wein AJ, Levin RM. Effect of partial outlet obstruction on contractility: comparison between severe and mild obstruction. Neurourol Urodyn. 1993;12:573
  7. Gillespie JI. A developing view of the origins of urgency: the importance of animal models. BJU Int. 2005;96(suppl.):22
  8. Iggo A. Tension receptors in the stomach and the urinary bladder. J Physiol. 1955;128:593
  9. Vaughan CW, Satchell PM. Urine storage mechanisms. Prog Neurobiol. 1995;46:215
  10. Mostwin JL, Karim OM, van Koeveringe G, et al. The guinea pig as a model of gradual urethral obstruction. J Urol. 1991;145:854
  11. Schroder A, Uvelius B, Newgreen D, et al. Bladder overactivity in mice after 1 week of outlet obstruction. Mainly afferent dysfunction? (J Urol). 2003;170:1017
  12. Baker SA, Hennig GW, Han J, et al. Methionine and its derivatives increase bladder excitability by inhibiting stretch-dependent K(+) channels. Br J Pharmacol. 2008;153:1259
  13. Herrera GM, Heppner TJ, Nelson MT. Regulation of urinary bladder smooth muscle contractions by ryanodine receptors and BK and SK channels. Am J Physiol Regul Integr Comp Physiol. 2000;279:R60
  14. Beckett EA, Han I, Baker SA, et al. Functional and molecular identification of pH-sensitive K+ channels in murine urinary bladder smooth muscle. BJU Int. 2008;102:113
  15. O'Driscoll KE, Hatton WJ, Burkin HR, et al. Expression, localization, and functional properties of Bestrophin 3 channel isolated from mouse heart. Am J Physiol Cell Physiol. 2008;295:C1610
  16. Wellner MC, Isenberg G. Properties of stretch-activated channels in myocytes from the guinea-pig urinary bladder. J Physiol. 1993;466:213
  17. Ji G, Barsotti RJ, Feldman ME, et al. Stretch-induced calcium release in smooth muscle. J Gen Physiol. 2002;119:533
  18. Farrugia G, Holm AN, Rich A, et al. A mechanosensitive calcium channel in human intestinal smooth muscle cells. Gastroenterology. 1999;117:900
  19. Li L, Jiang C, Hao P, et al. Changes in T-type calcium channel and its subtypes in overactive detrusor of the rats with partial bladder outflow obstruction. Neurourol Urodyn. 2007;26:870
  20. Li L, Jiang C, Song B, et al. Altered expression of calcium-activated K and Cl channels in detrusor overactivity of rats with partial bladder outlet obstruction. BJU Int. 2008;101:1588
  21. Brent L, Stephens FD. The response of smooth muscle cells in the rabbit urinary bladder to outflow obstruction. Invest Urol. 1975;12:494
  22. Malmqvist U, Arner A, Uvelius B. Cytoskeletal and contractile proteins in detrusor smooth muscle from bladders with outlet obstruction-a comparative study in rat and man. Scand J Urol Nephrol. 1991;25:261
  23. Ferguson DR, Kennedy I, Burton TJ. ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes—a possible sensory mechanism?. J Physiol. 1997;505:503
  24. Birder LA, Apodaca G, de Groat WC, et al. Adrenergic- and capsaicin-evoked nitric oxide release from urothelium and afferent nerves in urinary bladder. Am J Physiol. 1998;275:F226
  25. de Groat WC. A neurologic basis for the overactive bladder. Urology. 1997;50:36
  26. Kang D, Kim D. TREK-2 (K2P10.1) and TRESK (K2P18.1) are major background K+ channels in dorsal root ganglion neurons. Am J Physiol Cell Physiol. 2006;291:C138
  27. Park KJ, Baker SA, Cho SY, et al. Sulfur-containing amino acids block stretch-dependent K+ channels and nitrergic responses in the murine colon. Br J Pharmacol. 2005;144:1126

 Study received University of Nevada-Reno institutional animal use and care committee approval.

 Supported by National Institutes of Health P20-RR18751.

PII: S0022-5347(09)02620-2

doi: 10.1016/j.juro.2009.09.079

The Journal of Urology
Volume 183, Issue 2 , Pages 793-800 , February 2010

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