The Journal of Urology
Volume 183, Issue 2 , Pages 759-764 , February 2010

Ethylene Glycol Induced Hyperoxaluria Increases Plasma and Renal Tissue Asymmetrical Dimethylarginine in Rats: A New Pathogenetic Link in Hyperoxaluria Induced Disorders

  • Hasan Aydın

      Affiliations

    • Department of Internal Medicine (Section of Endocrinology and Metabolism), Yeditepe University Medical Faculty, Istanbul, Turkey
    • Corresponding Author InformationCorrespondence: Yeditepe Universitesi Hastanesi, Devlet Yolu Ankara Cad. No. 102, Kozyatagi, Istanbul 34752, Turkey (telephone: +90 216 5784106; FAX: +90 216 5784959)
    • ,
  • Faruk Yencilek

      Affiliations

    • Department of Urology, Yeditepe University Medical Faculty, Istanbul, Turkey
    • ,
  • Nilgün Mutlu

      Affiliations

    • Department of Biochemistry, Yeditepe University Medical Faculty, Istanbul, Turkey
    • ,
  • Nil Çomunoğlu

      Affiliations

    • Department of Pathology, Yeditepe University Medical Faculty, Istanbul, Turkey
    • ,
  • Hasbey Hakan Koyuncu

      Affiliations

    • Department of Urology, Yeditepe University Medical Faculty, Istanbul, Turkey
    • ,
  • Kemal Sarıca

      Affiliations

    • Department of Urology, Yeditepe University Medical Faculty, Istanbul, Turkey
    • Financial interest and/or other relationship with American Urological Association-European Urological Association Ureteral Stones Guidelines Panel.

Received 6 May 2009

References 

  1. Ramello A, Vitale C, Marangella M. Epidemiology of nephrolithiasis. J Nephrol. 2000;13(suppl.):S45
  2. Khan SR. Role of renal epithelial cells in the initiation of calcium oxalate stones. Nephron Exp Nephrol. 2004;98:55
  3. Green ML, Freel RW, Hatch M. Lipid peroxidation is not the underlying cause of renal injury in hyperoxaluric rats. Kidney Int. 2005;68:2629
  4. Hackett RL, Shevock PN, Khan SR. Cell injury associated calcium oxalate crystalluria. J Urol. 1990;144:1535
  5. Thamilselvan S, Khan SR, Menon M. Oxalate and calcium oxalate mediated free radical toxicity in renal epithelial cells: effect of antioxidants. Urol Res. 2003;31:3
  6. Linas SL, Repine JE. Endothelial cells regulate proximal tubule epithelial cell sodium transport. Kidney Int. 1999;55:1251
  7. Gobe GC, Johnson DW. Distal tubular epithelial cells of the kidney: potential support for proximal tubular cell survival after renal injury. Int J Biochem Cell Biol. 2007;39:1551
  8. Böger RH, Bode-Böger SM, Szuba A, et al. Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia. Circulation. 1998;98:1842
  9. Tojo A, Welch WJ, Bremer V. Colocalization of demethylating enzymes and NOS and functional effects of methylarginines in rat kidney. Kidney Int. 1997;52:1593
  10. McLay JS, Chatterjee P, Nicolson AG, et al. Nitric oxide production by human proximal tubular cells: a novel immunomodulatory mechanism?. Kidney Int. 1994;46:1043
  11. Verkoelen CF, van derBoom BG. Increased calcium oxalate monohydrate crystal binding to injured renal tubular epithelial cells in culture. Am J Physiol. 1998;274:F958
  12. Khan SR. Crystal-induced inflammation of the kidneys: results from human studies, animal models, and tissue-culture studies. Clin Exp Nephrol. 2004;8:75
  13. Khan SR, Kok DJ. Modulators of urinary stone formation. Front Biosci. 2004;9:1450
  14. Sarica K, Yagci F, Bakir K, et al. Renal tubular injury induced by hyperoxaluria: evaluation of apoptotic changes. Urol Res. 2001;29:34
  15. Tsujihata M. Mechanism of calcium oxalate renal stone formation and renal tubular cell injury. Int J Urol. 2008;15:115
  16. Iguchi M, Ikegami M, Kiwamoto H, et al. Effect of verapamil on urinary calcium and oxalate excretion in renal stone formers. Hinyokika Kiyo. 1993;39:425
  17. Sarica K, Erturhan S, Altay B. Effect of verapamil on urinary stone-forming risk factors. Urol Res. 2007;35:23
  18. Kedziora-Kornatowska K, Szram S, Kornatowski T, et al. The effect of verapamil on the antioxidant defence system in diabetic kidney. Clin Chim Acta. 2002;322:105
  19. Lüscher TF, Yang Z. Calcium antagonists and ACE inhibitors (Effect on endothelium and vascular smooth muscle). Drugs. 1993;46(suppl.):121
  20. Fishbein GA, Micheletti RG, Currier JS, et al. Atherosclerotic oxalosis in coronary arteries. Cardiovasc Pathol. 2008;17:117
  21. Recht PA, Tepedino GJ, Siecke NW, et al. Oxalic acid alters intracellular calcium in endothelial cells. Atherosclerosis. 2004;173:321
  22. Levin RI, Kantoff PW, Jaffe EA. Uremic levels of oxalic acid suppress replication and migration of human endothelial cells. Arteriosclerosis. 1990;10:198
  23. Falasca GF, Ramachandrula A, Kelley KA, et al. Superoxide anion production and phagocytosis of crystals by cultured endothelial cells. Arthritis Rheum. 1993;36:105
  24. Zoccali C. Asymmetric dimethylarginine in end-stage renal disease patients: a biomarker modifiable by calcium blockade and angiotensin II antagonism?. Kidney Int. 2006;70:2053
  25. Sakhaee K. Nephrolithiasis as a systemic disorder. Curr Opin Nephrol Hypertens. 2008;17:304
  26. Asplin JR. Obesity and urolithiasis. Adv Chronic Kidney Dis. 2009;16:11
  27. Laminski NA, Meyers AM, Kruger M, et al. Hyperoxaluria in patients with recurrent calcium oxalate calculi: dietary and other risk factors. Br J Urol. 1991;68:454
  28. Sarica K, Altay B, Erturhan S. Effect of being overweight on stone-forming risk factors. Urology. 2008;71:771
  29. Khan SR, Glenton PA, Byer KJ. Modeling of hyperoxaluric calcium oxalate nephrolithiasis: experimental induction of hyperoxaluria by hydroxy-L-proline. Kidney Int. 2006;70:914

 Study received Yeditepe University Medical Faculty animal care and use committee approval.

PII: S0022-5347(09)02617-2

doi: 10.1016/j.juro.2009.09.076

The Journal of Urology
Volume 183, Issue 2 , Pages 759-764 , February 2010

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