The Journal of Urology
Volume 183, Issue 2 , Pages 801-811 , February 2010

Novel Excitatory Effects of Adenosine Triphosphate on Contractile and Pacemaker Activity in Rabbit Urethral Smooth Muscle

Received 29 April 2009

References 

  1. Bridgewater M, MacNeil HF, Brading AF. Regulation of tone in pig urethral smooth muscle. J Urol. 1993;150:223
  2. Andersson KE. Neurotransmission and drug effects in urethral smooth muscle. Scand J Urol Nephrol Suppl. 2001;207:26
  3. Callahan SM, Creed KE. Electrical and mechanical activity of the isolated lower urinary tract of the guinea-pig. Br J Pharmacol. 1981;74:353
  4. Hills J, Meldrum LA, Klarskov P. A novel non-adrenergic, non-cholinergic nerve-mediated relaxation of the pig bladder neck: an examination of possible neurotransmitter candidates. Eur J Pharmacol. 1984;99:287
  5. Pinna C, Glass R, Knight GE. Purine- and pyrimidine-induced responses and P2Y receptor characterization in the hamster proximal urethra. Br J Pharmacol. 2005;144:510
  6. Pinna C, Puglisi L, Burnstock G. ATP and vasoactive intestinal polypeptide relaxant responses in hamster isolated proximal urethra. Br J Pharmacol. 1998;124:1069
  7. Pinna C, Ventura S, Puglisi L. A pharmacological and histochemical study of hamster urethra and the role of urothelium. Br J Pharmacol. 1996;119:655
  8. Ohnishi N, Park YC, Kurita T. Role of ATP and related purine compounds on urethral relaxation in male rabbits. Int J Urol. 1997;4:191
  9. Hashitani H, Edwards FR. Spontaneous and neurally activated depolarizations in smooth muscle cells of the guinea-pig urethra. J Physiol. 1999;514:459
  10. Hashitani H, Van Helden DF, Suzuki H. Properties of spontaneous depolarizations in circular smooth muscle cells of rabbit urethra. Br J Pharmacol. 1996;118:1627
  11. Sergeant GP, Hollywood MA, McCloskey KD. Specialised pacemaking cells in the rabbit urethra. J Physiol. 2000;526:359
  12. Sergeant GP, Thornbury KD, McHale NG. Characterization of norepinephrine-evoked inward currents in interstitial cells isolated from the rabbit urethra. Am J Physiol Cell Physiol. 2002;283:C885
  13. Sergeant GP, Johnston L, McHale NG. Activation of the cGMP/PKG pathway inhibits electrical activity in rabbit urethral interstitial cells of Cajal by reducing the spatial spread of Ca2+ waves. J Physiol. 2006;574:167
  14. Ward SM, Sanders KM. Involvement of intramuscular interstitial cells of Cajal in neuroeffector transmission in the gastrointestinal tract. J Physiol. 2006;576:675
  15. Rae J, Cooper K, Gates P. Low access resistance perforated patch recordings using amphotericin B. J Neurosci Methods. 1991;37:15
  16. Burnstock G, Kennedy C. Is there a basis for distinguishing two types of P2-purinoceptor?. Gen Pharmacol. 1985;16:433
  17. Abbracchio MP, Burnstock G. Purinoceptors: are there families of P2X and P2Y purinoceptors?. Pharmacol Ther. 1994;64:445
  18. Werkström V, Andersson KE. ATP- and adenosine-induced relaxation of the smooth muscle of the pig urethra. BJU Int. 2005;96:1386
  19. Hechler B, Nonne C, Roh EJ. MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y1 receptor with strong antithrombotic activity in mice. J Pharmacol Exp Ther. 2006;316:556
  20. Abbracchio MP, Burnstock G, Boeynaems JM. International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev. 2006;58:281
  21. Johnston L, Sergeant GP, Hollywood MA. Calcium oscillations in interstitial cells of the rabbit urethra. J Physiol. 2005;565:449
  22. Burnstock G, Dumsday B, Smythe A. Atropine resistant excitation of the urinary bladder: the possibility of transmission via nerves releasing a purine nucleotide. Br J Pharmacol. 1972;44:451
  23. Vial C, Evans RJ. P2X receptor expression in mouse urinary bladder and the requirement of P2X(1) receptors for functional P2X receptor responses in the mouse urinary bladder smooth muscle. Br J Pharmacol. 2000;131:1489
  24. Ford AP, Gever JR, Nunn PA. Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br J Pharmacol, suppl. 2006;147:S132
  25. Inoue R, Brading AF. The properties of the ATP-induced depolarization and current in single cells isolated from the guinea-pig urinary bladder. Br J Pharmacol. 1990;100:619
  26. Inoue R, Brading AF. Human, pig and guinea-pig bladder smooth muscle cells generate similar inward currents in response to purinoceptor activation. Br J Pharmacol. 1991;103:1840
  27. Lyons AD, Gardiner TA, McCloskey KD. Kit-positive interstitial cells in the rabbit urethra: structural relationships with nerves and smooth muscle. BJU Int. 2007;99:687
  28. García-Pascual A, Sancho M, Costa G. Interstitial cells of Cajal in the urethra are cGMP-mediated targets of nitrergic neurotransmission. Am J Physiol Renal Physiol. 2008;295:F971
  29. Rubino A, Ziabary L, Burnstock G. Regulation of vascular tone by UTP and UDP in isolated rat intrapulmonary arteries. Eur J Pharmacol. 1999;370:139
  30. Qasabian RA, Schyvens C, Owe-Young R. Characterization of the P2 receptors in rabbit pulmonary artery. Br J Pharmacol. 1997;120:553

 Study received institutional animal care and use committee approval.

 Supported by National Institutes of Health RO1 DK68565, Health Research Board PD/2005/4 and RP/2006/127, and the Council of Directors.

PII: S0022-5347(09)02616-0

doi: 10.1016/j.juro.2009.09.075

The Journal of Urology
Volume 183, Issue 2 , Pages 801-811 , February 2010