The Journal of Urology
Volume 183, Issue 2 , Pages 780-785 , February 2010

Bladder Dysfunction in a New Mutant Mouse Model With Increased Superoxide—Lack of Nitric Oxide?

  • Roberto Soler

      Affiliations

    • Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, North Carolina
    • Division of Urology, Federal University of São Paulo, São Paulo, Brazil
    • ,
  • Claudius Füllhase

      Affiliations

    • Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, North Carolina
    • Department of Urology, University Hospital Grosshadern, Ludwig-Maximilians-Universität München, Munich, Germany
    • ,
  • Baisong Lu

      Affiliations

    • Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, North Carolina
    • ,
  • Colin E. Bishop

      Affiliations

    • Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, North Carolina
    • ,
  • Karl-Erik Andersson

      Affiliations

    • Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, North Carolina
    • Corresponding Author InformationCorrespondence: Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Blvd., Winston Salem, North Carolina 27157 (telephone: 336-713-1195; FAX: 336-713-7290)
    • Financial interest and/or other relationship with Allergen, Astellas, Pfizer, Novartis and Lilly.

Received 23 April 2009

References 

  1. Sies H. Oxidative stress: oxidants and antioxidants. Exp Physiol. 1997;82:291
  2. Beshay E, Carrier S. Oxidative stress plays a role in diabetes-induced bladder dysfunction in a rat model. Urology. 2004;64:1062
  3. Aikawa K, Leggett RE, Levin RM. Effect of age on hydrogen peroxide mediated contraction damage in the male rat bladder. J Urol. 2003;170:2082
  4. Gomez-Pinilla PJ, Gomez MF, Sward K, et al. Melatonin restores impaired contractility in aged guinea pig urinary bladder. J Pineal Res. 2008;44:416
  5. de Jongh R, Dambros M, Haenen GR, et al. Partial bladder outlet obstruction reduces the tissue antioxidant capacity and muscle nerve density of the guinea pig bladder. Neurourol Urodyn. 2009;28:461
  6. Siflinger-Birnboim A, Levin RM, Hass MA. Partial outlet obstruction of the rabbit urinary bladder induces selective protein oxidation. Neurourol Urodyn. 2008;27:532
  7. Lin WY, Guven A, Juan YS, et al. Free radical damage as a biomarker of bladder dysfunction after partial outlet obstruction and reversal. BJU Int. 2008;101:621
  8. Leon J, Acuna-Castroviejo D, Sainz RM, et al. Melatonin and mitochondrial function. Life Sci. 2004;75:765
  9. Lu B, Poirier C, Gaspar T, et al. A mutation in the inner mitochondrial membrane peptidase 2-like gene (Immp2l) affects mitochondrial function and impairs fertility in mice. Biol Reprod. 2008;78:601
  10. Andersson KE, Arner A. Urinary bladder contraction and relaxation: physiology and pathophysiology. Physiol Rev. 2004;84:935
  11. Persson K, Igawa Y, Mattiasson A, et al. Effects of inhibition of the L-arginine/nitric oxide pathway in the rat lower urinary tract in vivo and in vitro. Br J Pharmacol. 1992;107:178
  12. Pandita RK, Mizusawa H, Andersson KE. Intravesical oxyhemoglobin initiates bladder overactivity in conscious, normal rats. J Urol. 2000;164:545
  13. Persson K, Pandita RK, Aszodi A, et al. Functional characteristics of urinary tract smooth muscles in mice lacking cGMP protein kinase type I. Am J Physiol Regul Integr Comp Physiol. 2000;279:R1112
  14. Burnett AL, Calvin DC, Chamness SL, et al. Urinary bladder-urethral sphincter dysfunction in mice with targeted disruption of neuronal nitric oxide synthase models idiopathic voiding disorders in humans. Nat Med. 1997;3:571
  15. de Jongh R, Haenen GR, van Koeveringe GA, et al. Oxidative stress reduces the muscarinic receptor function in the urinary bladder. Neurourol Urodyn. 2007;26:302
  16. Yoshida M, Miyamae K, Iwashita H, et al. Management of detrusor dysfunction in the elderly: changes in acetylcholine and adenosine triphosphate release during aging. Urology. 2004;63:17
  17. Masuda H, Kihara K, Saito K, et al. Reactive oxygen species mediate detrusor overactivity via sensitization of afferent pathway in the bladder of anaesthetized rats. BJU Int. 2008;101:775

 Study received institutional review board approval.

 Supported by a post-doctoral scholarship from the National Counsel of Technological and Scientific Development, Brazil (RS).

 See Editorial on page 423.

PII: S0022-5347(09)02615-9

doi: 10.1016/j.juro.2009.09.074

The Journal of Urology
Volume 183, Issue 2 , Pages 780-785 , February 2010

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