The Journal of Urology
Volume 182, Issue 5 , Pages 2103-2104 , November 2009

The Urothelial Glycosaminoglycan Layer Revisited

  • Monica Liebert

      Affiliations

    • Corresponding Author InformationRequests for reprints: 3875 Taubman Center PSC 5330, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109 (telephone: 734-615-6916)
    • Financial interest and/or other relationship with the Interstitial Cystitis Association, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Simon Foundation for Continence, American Journal of Physiology-Renal Physiology, Department of Defense, Urocore, Dako and Santa Cruz.

References 

  1. Khandelwal P, Abraham SN, Apodaca G. Cell biology and physiology of the uroepithelium. Am J Physiol Renal Physiol. 2009;Epub ahead of print
  2. Negrete HO, Lavelle JP, Berg J, et al. Permeability properties of the intact mammalian bladder epithelium. Am J Physiol. 1996;271:F886
  3. Parsons CL, Stauffer C, Schmidt JD. Bladder-surface glycosaminoglycans: an efficient mechanism of environmental adaptation. Science. 1980;208:605
  4. Hurst RE, Rhodes SW, Adamson PB, et al. Functional and structural characteristics of the glycosaminoglycans of the bladder luminal surface. J Urol. 1987;138:433
  5. Bhavanandan VP, Erickson DR. An investigation of the nature of bladder mucosal glycoconjugates and their role in interstitial cystitis. Indian J Biochem Biophys. 1997;34:205
  6. Parsons CL. The potassium sensitivity test: a new gold standard for diagnosing and understanding the pathophysiology of interstitial cystitis. J Urol. 2009;182:432
  7. Hanno P. Potassium sensitivity test for painful bladder syndrome/interstitial cystitis: con. J Urol. 2009;182:431
  8. Erickson DR, Herb N, Ordille S, et al. A new direct test of bladder permeability. J Urol. 2000;164:419
  9. Slobodov G, Feloney M, Gran C, et al. Abnormal expression of molecular markers for bladder impermeability and differentiation in the urothelium of patients with interstitial cystitis. J Urol. 2004;171:1554
  10. Nickel JC, Egerdie B, Downey J, et al. A real-life multicentre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystitis. BJU Int. 2009;103:56

PII: S0022-5347(09)02112-0

doi: 10.1016/j.juro.2009.08.080

The Journal of Urology
Volume 182, Issue 5 , Pages 2103-2104 , November 2009

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