The Journal of Urology
Volume 182, Issue 6, Supplement , Pages S32-S37 , December 2009

Diabetes and Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms—What do We Know?

  • Aruna V. Sarma

      Affiliations

    • Department of Epidemiology, University of Michigan, Ann Arbor, Michigan
    • Corresponding Author InformationCorrespondence: Departments of Urology and Epidemiology, University of Michigan, Room 1025, Michigan House, 2301 Commonwealth Blvd., Ann Arbor, Michigan 48105-2967 (telephone: 734-763-7514; FAX: 734-232-2400)
  • ,
  • J. Kellogg Parsons

      Affiliations

    • Department of Urology, University of California-San Diego, San Diego, California
    • Financial interest and/or other relationship with American Medical Systems.
  • ,
  • Kevin McVary

      Affiliations

    • Department of Urology, Northwestern University, Chicago, Illinois
    • Financial interest and/or other relationship with GlaxoSmithKline, Pfizer, Lilly/ICOS, Sanovi Aventis, Allergan and National Institutes of Diabetes and Digestive and Kidney Diseases.
  • ,
  • John T. Wei

      Affiliations

    • University of Michigan, Department of Urology, Ann Arbor, Michigan
    • Financial interest and/or other relationship with Sanofi, American Medical Systems, Envisioneering, Gen-Probe and Beckman.

References 

  1. Wei JT, Calhoun E, Jacobsen SJ. Urologic Diseases in America Project: benign prostatic hyperplasia. J Urol. 2005;173:1256
  2. Sarma AV, Parsons JK. Diabetes and benign prostatic hyperplasia: emerging clinical connections. Curr Urol Rep. 2009;10:4
  3. Berry SJ, Coffey DS, Walsh PC, et al. The development of human benign prostatic hyperplasia with age. J Urol. 1984;132:474
  4. Rohrmann S, Smit E, Giovannucci E, et al. Association between markers of the metabolic syndrome and lower urinary tract symptoms in the Third National Health and Nutrition Examination Survey (NHANES III). Int J Obesity. 2005;29:310
  5. Sasaki K, Yoshimura N, Chancellor MB. Implications of diabetes mellitus in urology. Urol Clin North Am. 2003;30:1
  6. Frimodt-Moller C. Diabetic cystopathy: epidemiology and related disorders. Ann Intern Med. 1980;92:318
  7. Kaplan SE, Te AE, Blaivas JG. Urodynamic findings in patients with diabetic cystopathy. J Urol. 1995;153:342
  8. Sarma AV, Burke JP, Jacobson DJ, et al. Associations between diabetes and clinical markers of benign prostatic hyperplasia among community-dwelling Black and White men. Diabetes Care. 2008;31:476
  9. Michel MC, Mehlburger L, Schumacher H, et al. Effect of diabetes on lower urinary tract symptoms in patients with benign prostatic hyperplasia. J Urol. 2000;163:1725
  10. Parsons JK, Carter HB, Partin AW, et al. Metabolic factors associated with benign prostatic hyperplasia. J Clin Endocrinol Metab. 2006;91:2562
  11. Hammarsten J, Hogstedt B. Hyperinsulinaemia as a risk factor for developing benign prostatic hyperplasia. Eur Urol. 2001;39:151
  12. Hammarsten J, Hogstedt B. Clinical, anthropometric, metabolic and insulin profile of men with fast annual growth rates of benign prostatic hyperplasia. Blood Press. 1999;8:29
  13. Hammarsten J, Hogstedt B, Holthuis N, et al. Components of the metabolic syndrome-risk factors for the development of benign prostatic hyperplasia. Prostate Cancer Prostatic Dis. 1998;1:157
  14. Nandeesha H, Koner BC, Dorairajan LN, et al. Hyperinsulinemia and dyslipidemia in non-diabetic benign prostatic hyperplasia. Clin Chim Acta. 2006;370:89
  15. Parsons JK, Bergstrom J, Barrett-Connor E. Lipids, lipoproteins and the risk of benign prostatic hyperplasia in community-dwelling men. BJU Int. 2008;101:313
  16. Boon TA, Van Venrooij GE, Eckhardt MD. Effect of diabetes mellitus on lower urinary tract symptoms and dysfunction in patients with benign prostatic hyperplasia. Curr Urol Rep. 2001;2:297
  17. Kristal AR, Arnold KB, Schenk JM, et al. Race/ethnicity, obesity, health related behaviors and the risk of symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial. J Urol. 2007;177:1395
  18. Burke JP, Jacobson DJ, McGree M, et al. Diabetes and benign prostatic hyperplasia progression in Olmsted County, Minnesota. Urology. 2006;67:22
  19. Chokkalingam AP, Gao YT, Deng J, et al. Insulin-like growth factors and risk of benign prostatic hyperplasia. Prostate. 2002;52:98
  20. Glynn RJ, Campion EW, Bouchard GR, et al. The development of benign prostatic hyperplasia among volunteers in the Normative Aging Study. Am J Epidemiol. 1985;121:78
  21. Sidney S, Quesenberry C, Sadler MC, et al. Risk factors for surgically treated benign prostatic hyperplasia in a prepaid health care plan. Urology. 1991;38:13
  22. Meigs JB, Mohr B, Barry MJ, et al. Risk factors for clinical benign prostatic hyperplasia in a community-based population of healthy aging men. J Clin Epidemiol. 2001;54:935
  23. Van Den Eeden SK, Enger S, Caan BL, et al. Urologic conditions and diabetes in the California Men's Health Study. In: Urologic Complications of Diabetes. Bethesda: National Institutes of Health; 2003;p. 49;abstract
  24. Brown JS, Wessells H, Chancellor MB, et al. Urologic complications of diabetes. Diabetes Care. 2005;28:177
  25. Rohrmann S, Platz EA, Giovannucci E. Lifestyle and benign prostatic hyperplasia in older men: what do we know?. J Men's Health Gender. 2005;2:230
  26. McVary KT, Rademaker A, Lloyd GL, et al. Autonomic nervous system overactivity in men with lower urinary tract symptoms secondary to benign prostatic hyperplasia. J Urol. 2005;174:1327
  27. Cohen P, Peehl DM, Rosenfeld RG. The IGF axis in the prostate. Horm Metab Res. 1994;26:81
  28. Sarma AV, Jaffe CA, Schottenfeld D, et al. Insulin-like growth factor-1, insulin-like growth factor binding protein-3, and body mass index: clinical correlates of prostate volume among black men. Urology. 2002;59:362
  29. Furukawa S, Fujita T, Shimabukuro M, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 2004;114:1752
  30. Kramer G, Mitteregger D, Marberger M. Is benign prostatic hyperplasia (BPH) an immune inflammatory disease?. Eur Urol. 2007;51:1202
  31. Sciarra A, Di SF, Salciccia S, et al. Inflammation and chronic prostatic diseases: evidence for a link?. Eur Urol. 2007;52:964

PII: S0022-5347(09)01904-1

doi: 10.1016/j.juro.2009.07.088

The Journal of Urology
Volume 182, Issue 6, Supplement , Pages S32-S37 , December 2009