The Journal of Urology
Volume 182, Issue 5 , Pages 2226-2231 , November 2009

Exercise and Prostate Cancer Risk in a Cohort of Veterans Undergoing Prostate Needle Biopsy

  • Jodi A. Antonelli

      Affiliations

    • Duke Prostate Center, Division of Urologic Surgery, Duke University Medical Center, Durham, North Carolina
    • Section of Urology, Department of Surgery, Durham Veterans Affairs Medical Center, Durham, North Carolina
    • ,
  • Lee W. Jones

      Affiliations

    • Robert Preston Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina
    • ,
  • Lionel L. Bañez

      Affiliations

    • Duke Prostate Center, Division of Urologic Surgery, Duke University Medical Center, Durham, North Carolina
    • Section of Urology, Department of Surgery, Durham Veterans Affairs Medical Center, Durham, North Carolina
    • ,
  • Jean-Alfred Thomas

      Affiliations

    • Duke Prostate Center, Division of Urologic Surgery, Duke University Medical Center, Durham, North Carolina
    • Section of Urology, Department of Surgery, Durham Veterans Affairs Medical Center, Durham, North Carolina
    • ,
  • Kelly Anderson

      Affiliations

    • Duke Prostate Center, Division of Urologic Surgery, Duke University Medical Center, Durham, North Carolina
    • Section of Urology, Department of Surgery, Durham Veterans Affairs Medical Center, Durham, North Carolina
    • ,
  • Loretta A. Taylor

      Affiliations

    • Duke Prostate Center, Division of Urologic Surgery, Duke University Medical Center, Durham, North Carolina
    • Section of Urology, Department of Surgery, Durham Veterans Affairs Medical Center, Durham, North Carolina
    • ,
  • Leah Gerber

      Affiliations

    • Duke Prostate Center, Division of Urologic Surgery, Duke University Medical Center, Durham, North Carolina
    • Section of Urology, Department of Surgery, Durham Veterans Affairs Medical Center, Durham, North Carolina
    • ,
  • Tiffany Anderson

      Affiliations

    • Section of Urology, Department of Surgery, Durham Veterans Affairs Medical Center, Durham, North Carolina
    • JLC-Biomedical/Biotechnology Research Institute, Cancer Research Program, North Carolina Central University, Durham, North Carolina
    • ,
  • Catherine Hoyo

      Affiliations

    • Department of Surgery, Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina
    • ,
  • Delores Grant

      Affiliations

    • JLC-Biomedical/Biotechnology Research Institute, Cancer Research Program, North Carolina Central University, Durham, North Carolina
    • ,
  • Stephen J. Freedland

      Affiliations

    • Duke Prostate Center, Division of Urologic Surgery, Duke University Medical Center, Durham, North Carolina
    • Department of Pathology, Duke University Medical Center, Durham, North Carolina
    • Section of Urology, Department of Surgery, Durham Veterans Affairs Medical Center, Durham, North Carolina
    • Corresponding Author InformationCorrespondence: Division of Urology, Department of Surgery, Box 2626, Duke University Medical Center, Durham, North Carolina 27710 (telephone: 919-668-5946; FAX: 919-668-7093)

Received 3 March 2009

References 

  1. Barnard RJ, Leung PS, Aronson WJ, et al. A mechanism to explain how regular exercise might reduce the risk for clinical prostate cancer. Eur J Cancer Prev. 2007;16:415
  2. Leung PS, Aronson WJ, Ngo TH, et al. Exercise alters the IGF axis in vivo and increases p53 protein in prostate tumor cells in vitro. J Appl Physiol. 2004;96:450
  3. Ornish D, Weidner G, Fair WR, et al. Intensive lifestyle changes may affect the progression of prostate cancer. J Urol. 2005;174:1065
  4. Ji LL, Gomez-Cabrera MC, Vina J. Exercise and hormesis: activation of cellular antioxidant signaling pathway. Ann N Y Acad Sci. 2006;1067:425
  5. Sies H. Oxidative stress: from basic research to clinical application. Am J Med. 1991;91:31S
  6. Garcia-Hernandez Mde L, Gray A, Hubby B, et al. Prostate stem cell antigen vaccination induces a long-term protective immune response against prostate cancer in the absence of autoimmunity. Cancer Res. 2008;68:861
  7. Fairey AS, Courneya KS, Field CJ, et al. Physical exercise and immune system function in cancer survivors: a comprehensive review and future directions. Cancer. 2002;94:539
  8. Bairati I, Larouche R, Meyer F, et al. Lifetime occupational physical activity and incidental prostate cancer (Canada). Cancer Causes Control. 2000;11:759
  9. Giovannucci EL, Liu Y, Leitzmann MF, et al. A prospective study of physical activity and incident and fatal prostate cancer. Arch Intern Med. 2005;165:1005
  10. Moore SC, Peters TM, Ahn J, et al. Physical activity in relation to total, advanced, and fatal prostate cancer. Cancer Epidemiol Biomarkers Prev. 2008;17:2458
  11. Norman A, Moradi T, Gridley G, et al. Occupational physical activity and risk for prostate cancer in a nationwide cohort study in Sweden. Br J Cancer. 2002;86:70
  12. Lee IM, Sesso HD, Paffenbarger RS. A prospective cohort study of physical activity and body size in relation to prostate cancer risk (United States). Cancer Causes Control. 2001;12:187
  13. Cerhan JR, Torner JC, Lynch CF, et al. Association of smoking, body mass, and physical activity with risk of prostate cancer in the Iowa 65+ Rural Health Study (United States). Cancer Causes Control. 1997;8:229
  14. Godin G, Jobin J, Bouillon J. Assessment of leisure time exercise behavior by self-report: a concurrent validity study. Can J Public Health. 1986;77:359
  15. Haskell WL, Lee IM, Pate RR, et al. Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Med Sci Sports Exerc. 2007;39:1423
  16. Holmes MD, Chen WY, Feskanich D, et al. Physical activity and survival after breast cancer diagnosis. JAMA. 2005;293:2479
  17. Charlson ME, Pompei P, Ales KL, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373
  18. Antonelli J, Freedland SJ, Jones LW. Exercise therapy across the prostate cancer continuum. Prostate Cancer Prostatic Dis. 2009;12:110
  19. McTiernan A. Mechanisms linking physical activity with cancer. Nat Rev Cancer. 2008;8:205
  20. Dal Maso L, Zucchetto A, Tavani A, et al. Lifetime occupational and recreational physical activity and risk of benign prostatic hyperplasia. Int J Cancer. 2006;118:2632
  21. Williams PT. Effects of running distance and performance on incident benign prostatic hyperplasia. Med Sci Sports Exerc. 2008;40:1733

 Study received institutional review board approval.

 Supported by the Department of Veterans Affairs, Department of Defense and the American Urological Association Foundation/Astellas Rising Stars in Urology Award.

 See Editorial on page 2101.

PII: S0022-5347(09)01757-1

doi: 10.1016/j.juro.2009.07.028

The Journal of Urology
Volume 182, Issue 5 , Pages 2226-2231 , November 2009

Article Tools