The Journal of Urology
Volume 182, Issue 4 , Pages 1287-1293 , October 2009

Tumor Size is a Determinant of the Rate of Stage T1 Renal Cell Cancer Synchronous Metastasis

  • Giovanni Lughezzani

      Affiliations

    • Cancer Prognosis and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada
    • Department of Urology, Vita-Salute San Raffaele University, Milan, Italy
    • ,
  • Claudio Jeldres

      Affiliations

    • Cancer Prognosis and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada
    • ,
  • Hendrik Isbarn

      Affiliations

    • Cancer Prognosis and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada
    • Martini-clinic, Prostate Cancer Center Hamburg-Eppendorf, Hamburg, Germany
    • ,
  • Paul Perrotte

      Affiliations

    • Department of Urology, University of Montreal, Montreal, Quebec, Canada
    • ,
  • Shahrokh F. Shariat

      Affiliations

    • Cancer Prognosis and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada
    • ,
  • Maxine Sun

      Affiliations

    • Cancer Prognosis and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada
    • ,
  • Hugues Widmer

      Affiliations

    • Department of Urology, University of Montreal, Montreal, Quebec, Canada
    • ,
  • Philippe Arjane

      Affiliations

    • Department of Urology, University of Montreal, Montreal, Quebec, Canada
    • ,
  • Francois Peloquin

      Affiliations

    • Department of Urology, University of Montreal, Montreal, Quebec, Canada
    • ,
  • Daniel Pharand

      Affiliations

    • Department of Urology, University of Montreal, Montreal, Quebec, Canada
    • ,
  • Jean-Jacques Patard

      Affiliations

    • Department of Urology, Rennes University Hospital, Rennes, France
    • ,
  • Markus Graefen

      Affiliations

    • Martini-clinic, Prostate Cancer Center Hamburg-Eppendorf, Hamburg, Germany
    • ,
  • Francesco Montorsi

      Affiliations

    • Department of Urology, Vita-Salute San Raffaele University, Milan, Italy
    • ,
  • Pierre I. Karakiewicz

      Affiliations

    • Cancer Prognosis and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada
    • Corresponding Author InformationCorrespondence: Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, 1058, rue St-Denis, Montréal, Québec, Canada, H2X 3J4 (telephone: 514-890-8000-35336; FAX: 514-412-7363)

Received 26 January 2009

References 

  1. Herrlinger A, Schott G, Schafhauser W, et al. The significance of tumor diameter in renal cell carcinoma. Urologe A. 1992;31:70
  2. Eschwege P, Saussine C, Steichen G, et al. Radical nephrectomy for renal cell carcinoma 30 mm. or less: long-term follow results. J Urol. 1996;155:1196
  3. Remzi M, Ozsoy M, Klingler HC, et al. Are small renal tumors harmless? (Analysis of histopathological features according to tumors 4 cm or less in diameter). J Urol. 2006;176:896
  4. Crispen PL, Boorjian SA, Lohse CM, et al. Outcomes following partial nephrectomy by tumor size. J Urol. 2008;180:1912
  5. Klatte T, Patard JJ, de Martino M, et al. Tumor size does not predict risk of metastatic disease or prognosis of small renal cell carcinomas. J Urol. 2008;179:1719
  6. Ries LAG, Melbert D, Krapcho M, et al. SEER Cancer Statistics Review, 1975-2004, based on November 2006 SEER data submission (National Cancer Institute, Surveillance Epidemiology and End Results). http://seer.cancer.gov/csr/1975_2004/Accessed January 2007.
  7. Woldrich JM, Mallin K, Ritchey J, et al. Sex differences in renal cell cancer presentation and survival: an analysis of the National Cancer Database, 1993–2004. J Urol. 2008;179:1709
  8. Karakiewicz PI, Lewinshtein DJ, Chun FK, et al. Tumor size improves the accuracy of TNM predictions in patients with renal cancer. Eur Urol. 2006;50:521
  9. Hutterer GC, Patard JJ, Jeldres C, et al. Patients with distant metastases from renal cell carcinoma can be accurately identified: external validation of a new nomogram. BJU Int. 2008;101:39
  10. Kattan MW, Reuter V, Motzer RJ, et al. A postoperative prognostic nomogram for renal cell carcinoma. J Urol. 2001;166:63
  11. Sorbellini M, Kattan MW, Snyder ME, et al. A postoperative prognostic nomogram predicting recurrence for patients with conventional clear cell renal cell carcinoma. J Urol. 2005;173:48
  12. Zisman A, Pantuck AJ, Wieder J, et al. Risk group assessment and clinical outcome algorithm to predict the natural history of patients with surgically resected renal cell carcinoma. J Clin Oncol. 2002;20:4559
  13. Karakiewicz PI, Briganti A, Chun FK, et al. Multi-institutional validation of a new renal cancer-specific survival nomogram. J Clin Oncol. 2007;25:1316
  14. Klatte T, Patard JJ, Goel RH, et al. Prognostic impact of tumor size on pT2 renal cell carcinoma: an international multicenter experience. J Urol. 2007;178:35
  15. Lam JS, Klatte T, Patard JJ, et al. Prognostic relevance of tumour size in T3a renal cell carcinoma: a multicentre experience. Eur Urol. 2007;52:155
  16. Shannon BA, Cohen RJ, de Bruto H, et al. The value of preoperative needle core biopsy for diagnosing benign lesions among small, incidentally detected renal masses. J Urol. 2008;180:1257
  17. Karakiewicz PI, Hutterer GC, Trinh QD, et al. Unclassified renal cell carcinoma: an analysis of 85 cases. BJU Int. 2007;100:802
  18. Karakiewicz PI, Trinh QD, Rioux-Leclercq N, et al. Collecting duct renal cell carcinoma: a matched analysis of 41 cases. Eur Urol. 2007;52:1140
  19. Kuroda N, Toi M, Hiroi M, et al. Review of sarcomatoid renal cell carcinoma with focus on clinical and pathobiological aspects. Histol Histopathol. 2003;18:551

 Study received institutional review board approval.

 Supported by the University of Montreal Urology Associates, Fonds de la Recherche en Santé du Québec, University of Montreal Department of Surgery and University of Montreal Foundation (PIK).

 For another article on a related topic see page 1594.

PII: S0022-5347(09)01487-6

doi: 10.1016/j.juro.2009.06.018

The Journal of Urology
Volume 182, Issue 4 , Pages 1287-1293 , October 2009

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