The Journal of Urology
Volume 182, Issue 2 , Pages 735-740 , August 2009

Topoisomerase II α Status in Renal Medullary Carcinoma: Immuno-Expression and Gene Copy Alterations of a Potential Target of Therapy

  • Roula Albadine

      Affiliations

    • Department of Pathology, Johns Hopkins University, Baltimore, Maryland
    • ,
  • Wenle Wang

      Affiliations

    • Department of Pathology, Johns Hopkins University, Baltimore, Maryland
    • ,
  • Noel A. Brownlee

      Affiliations

    • Department of Pathology, Johns Hopkins University, Baltimore, Maryland
    • ,
  • Antoun Toubaji

      Affiliations

    • Department of Pathology, Johns Hopkins University, Baltimore, Maryland
    • ,
  • Athanase Billis

      Affiliations

    • University of Campinas, São Paolo, Brazil
    • ,
  • Perdram Argani

      Affiliations

    • Department of Pathology, Johns Hopkins University, Baltimore, Maryland
    • ,
  • Jonathan I. Epstein

      Affiliations

    • Johns Hopkins University, Baltimore, Maryland
    • ,
  • A. Julian Garvin

      Affiliations

    • Department of Pathology, Wake Forest University, Winston-Salem, North Carolina
    • ,
  • Rima Cousi

      Affiliations

    • Department of Oncology, Johns Hopkins University, Baltimore, Maryland
    • ,
  • Edward M. Schaeffer

      Affiliations

    • Department of Urology, Johns Hopkins University, Baltimore, Maryland
    • ,
  • Christian Pavlovich

      Affiliations

    • Department of Urology, Johns Hopkins University, Baltimore, Maryland
    • ,
  • George J. Netto

      Affiliations

    • Johns Hopkins University, Baltimore, Maryland
    • Corresponding Author InformationCorrespondence: 401 North Broadway/Weinberg 2242, Baltimore, Maryland 21231

Received 24 October 2008

References 

  1. Davis CJ, Mostofi FK, Sesterhenn IA. Renal medullary carcinoma (The seventh sickle cell nephropathy). Am J Surg Pathol. 1995;19:1
  2. Coogan CL, McKiel CF, Flanagan MJ, et al. Renal medullary carcinoma in patients with sickle cell trait. Urology. 1998;51:1049
  3. Swartz MA, Karth J, Schneider DT, et al. Renal medullary carcinoma: clinical, pathologic, immunohistochemical, and genetic analysis with pathogenetic implications. Urology. 2002;60:1083
  4. Dimashkieh H, Choe J, Mutema G. Renal medullary carcinoma: a report of 2 cases and review of the literature. Arch Pathol Lab Med. 2003;127:e135
  5. Hakimi AA, Koi PT, Milhoua PM, et al. Renal medullary carcinoma: the Bronx experience. Urology. 2007;70:878
  6. Watanabe IC, Billis A, Guimaraes MS, et al. Renal medullary carcinoma: report of seven cases from Brazil. Mod Pathol. 2007;20:914
  7. Wang JC. Cellular roles of DNA topoisomerases: a molecular perspective. Nat Rev Mol Cell Biol. 2002;3:430
  8. Yang XJ, Sugimura J, Tretiakova MS, et al. Gene expression profiling of renal medullary carcinoma: potential clinical relevance. Cancer. 2004;100:976
  9. Jarvinen TA, Tanner M, Rantanen V, et al. Amplification and deletion of topoisomerase IIalpha associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer. Am J Pathol. 2000;156:839
  10. Bhargava R, Lal P, Chen B. HER-2/neu and topoisomerase IIa gene amplification and protein expression in invasive breast carcinomas: chromogenic in situ hybridization and immunohistochemical analyses. Am J Clin Pathol. 2005;123:889
  11. Hicks DG, Yoder BJ, Pettay J, et al. The incidence of topoisomerase II-alpha genomic alterations in adenocarcinoma of the breast and their relationship to human epidermal growth factor receptor-2 gene amplification: a fluorescence in situ hybridization study. Hum Pathol. 2005;36:348
  12. Mueller RE, Parkes RK, Andrulis I, et al. Amplification of the TOP2A gene does not predict high levels of topoisomerase II alpha protein in human breast tumor samples. Genes Chromosomes Cancer. 2004;39:288
  13. Yabuki N, Sasano H, Kato K, et al. Immunohistochemical study of DNA topoisomerase II in human gastric disorders. Am J Pathol. 1996;149:997
  14. Fogt F, Nikulasson ST, Holden JA, et al. Topoisomerase II alpha expression in normal, inflammatory, and neoplastic conditions of the gastric and colonic mucosa. Mod Pathol. 1997;10:296
  15. Fortune JM, Osheroff N. Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage. J Biol Chem. 1998;273:17643
  16. Tanner M, Isola J, Wiklund T, et al. Scandinavian Breast Group Trial 9401 Topoisomerase IIalpha gene amplification predicts favorable treatment response to tailored and dose-escalated anthracycline-based adjuvant chemotherapy in HER-2/neu-amplified breast cancer: Scandinavian Breast Group Trial 9401. J Clin Oncol. 2006;24:2428
  17. Zhou Z, Zwelling LA, Kawakami Y, et al. Adenovirus-mediated human topoisomerase IIalpha gene transfer increases the sensitivity of etoposide-resistant human breast cancer cells. Cancer Res. 1999;59:4618
  18. Scheltema JM, Romijn JC, van Steenbrugge GJ, et al. Decreased levels of topoisomerase II alpha in human renal cell carcinoma lines resistant to etoposide. J Cancer Res Clin Oncol. 1997;123:546
  19. Isaacs RJ, Davies SL, Sandri MI, et al. Physiological regulation of eukaryotic topoisomerase II. Biochim Biophys Acta. 1998;1400:121
  20. Barker CR, Mouchel NA, Jenkins JR. The identification and characterisation of a functional interaction between arginyl-tRNA-protein transferase and topoisomerase II. Biochem Biophys Res Commun. 2006;342:596
  21. Tretiakova M, Turkyilmaz M, Grushko T, et al. Topoisomerase IIalpha in Wilms' tumour: gene alterations and immunoexpression. J Clin Pathol. 2006;59:1272

 Study received institutional review board approval.

 Supported by the Patrick C. Walsh Foundation Award.

PII: S0022-5347(09)00879-9

doi: 10.1016/j.juro.2009.03.078

The Journal of Urology
Volume 182, Issue 2 , Pages 735-740 , August 2009

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