The Journal of Urology
Volume 182, Issue 4, Supplement , Pages 1669-1672 , October 2009

Linkage Analysis of Candidate Genes in Families With Vesicoureteral Reflux

  • Helena Kelly

      Affiliations

    • Children's Research Centre, Our Lady's Children's Hospital, Dublin, Ireland
    • National Centre for Medical Genetics, Our Lady's Children's Hospital, Dublin, Ireland
    • ,
  • David Barton

      Affiliations

    • National Centre for Medical Genetics, Our Lady's Children's Hospital, Dublin, Ireland
    • University College Dublin Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
    • ,
  • Cliona Molony

      Affiliations

    • Rosetta Inpharmatics, Seattle, Washington
    • ,
  • Prem Puri

      Affiliations

    • Children's Research Centre, Our Lady's Children's Hospital, Dublin, Ireland
    • National Children's Hospital, Dublin, Ireland
    • University College Dublin Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
    • Corresponding Author InformationCorrespondence: Children's Research Centre, Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland (telephone: 0035314096420)

References 

  1. Smellie JM, Barratt TM, Chantler C, et al. Medical versus surgical treatment in children with severe bilateral vesicoureteric reflux and bilateral nephropathy: a randomised trial. Lancet. 2001;357:1329
  2. Hoberman A, Charron M, Hickey RW, et al. Imaging studies after a first febrile urinary tract infection in young children. N Engl J Med. 2003;348:195
  3. Marra G, Oppezo C, Ardission G, et al. Severe vesicoureteral reflux and chronic renal failure: a condition peculiar to male gender?. Data from the Italkid Project J Pediatr. 2004;144:677
  4. Noe HN. The long-term results of prospective sibling reflux screening. J Urol. 1992;148:1739
  5. Parekh DJ, Pope JCT, Adams MC, et al. Outcome of sibling vesicoureteral reflux. J Urol. 2002;167:283
  6. Chertin B, Puri P. Familial vesicoureteral reflux. J Urol. 2003;169:1804
  7. Hu P, Deng FM, Liang FX, et al. Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux. J Cell Biol. 2000;151:961
  8. Lu W, van Eerde AM, Fan X, et al. Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. Am J Hum Genet. 2007;80:616
  9. Koolen DA, Herbergs J, Veltman JA, et al. Holoprosencephaly and preaxial polydactyly associated with a 1.24 Mb duplication encompassing FBXW11 at 5q35.1. J Hum Genet. 2006;51:721
  10. Ogata T, Muroya K, Sasagawa I, et al. Genetic evidence for a novel gene(s) involved in urogenital development on 10q26. Kidney Int. 2000;58:2281
  11. Feather SA, Malcolm S, Woolf AS, et al. Primary, nonsyndromic vesicoureteric reflux and its nephropathy is genetically heterogeneous, with a locus on chromosome 1. Am J Hum Genet. 2000;66:1420
  12. Kelly H, Molony CM, Darlow JM, et al. A genome-wide scan for genes involved in primary vesicoureteric reflux. J Med Genet. 2007;44:710
  13. Conte ML, Bertoli-Avella AM, de Graaf BM, et al. A genome search for primary vesicoureteral reflux shows further evidence for genetic heterogeneity. Pediatr Nephrol. 2008;23:587
  14. Pirker ME, Mohanan N, Colhoun E, et al. Familial vesicoureteral reflux: influence of sex on prevalence and expression. J Urol. 2006;176:1776
  15. Kruglyak L, Daly MJ, Reeve-Daly MP, et al. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet. 1996;58:1347
  16. Chapman CJ, Bailey RR, Janus ED, et al. Vesicoureteric reflux: segregation analysis. Am J Med Genet. 1985;20:577
  17. Kelly H, Ennis S, Yoneda A, et al. Uroplakin III is not a major candidate gene for primary vesicoureteral reflux. Eur J Hum Genet. 2005;13:500
  18. Giltay JC, van de Meerakker J, van Amstel HK, et al. No pathogenic mutations in the uroplakin III gene of 25 patients with primary vesicoureteral reflux. J Urol. 2004;171:931
  19. Jiang S, Gitlin J, Deng FM, et al. Lack of major involvement of human uroplakin genes in vesicoureteral reflux: implications for disease heterogeneity. Kidney Int. 2004;66:10
  20. Yoneda A, Cascio S, Green A, et al. Angiotensin II type 2 receptor gene is not responsible for familial vesicoureteral reflux. J Urol. 2002;168:1138

 Study received institutional review board approval.

 Supported by a grant from The Children's Medical and Research Foundation, Our Lady's Hospital for Sick Children, Crumlin, Dublin 12.

PII: S0022-5347(09)00645-4

doi: 10.1016/j.juro.2009.03.013

The Journal of Urology
Volume 182, Issue 4, Supplement , Pages 1669-1672 , October 2009

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