The Journal of Urology
Volume 182, Issue 1 , Pages 237-248 , July 2009

Efficacy of Coenzyme Q10 on Semen Parameters, Sperm Function and Reproductive Hormones in Infertile Men

  • Mohammad Reza Safarinejad

      Affiliations

    • Corresponding Author InformationCorrespondence: P. O. Box 19395-1849, Tehran, Iran (telephone: 0098 21 22454499; FAX: 0098 21 22456845)

Received 5 November 2008

References 

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  5. Santos-Ocaña C, Do TQ, Padilla S, Navas P, Clarke CF. Uptake of exogenous coenzyme Q and transport to mitochondria is required for bc 1 complex stability in yeast coQ mutants. J Biol Chem. 2002;277:10973
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  8. Mancini A, Milardi D, Conte G, Festa R, De Marinis L, Littarru GP. Seminal antioxidants in humans: preoperative and postoperative evaluation of coenzyme Q10 in varicocele patients. Hormon Metab Res. 2005;37:428
  9. Alleva R, Scararmucci A, Mantero F, Bompadre S, Leoni L, Littarru GP. The protective role of ubiquinol-10 against formation of lipid hydroperoxides in human seminal fluid. Mol Aspects Med. 1997;18(suppl.):S221
  10. Balercia G, Buldreghini E, Vignini A, Tiano L, Paggi F, Amoroso S, et al. Coenzyme Q(10) treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial. Fertil Steril. 2008;Epub ahead of print
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  13. Tang PH, Miles MV, DeGrauw A, Hershey A, Pesce A. HPLC analysis of reduced and oxidised coenzyme Q10 in human plasma. Clin Chem. 2001;47:256
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  16. Aitken RJ, Clarkson JS. Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa. J Reprod Fertil. 1987;81:459
  17. Watts GF, Playford DA, Croft KD, Ward NC, Mori TA, Burke V. Coenzyme Q(10) improves endothelial dysfunction of the brachial artery in type II diabetes mellitus. Diabetologia. 2002;45:420
  18. Coughlin MT, Bellinger MF, Lee PA. Age at unilateral orchiopexy: effect on hormone levels and sperm count in adulthood. J Urol. 1999;162:986
  19. Mancini A, Bianchi A, Fusco A, Sacco E, Leone E, Tilaro L, et al. Coenzyme Q10 evaluation in pituitary-adrenal axis disease: preliminary data. Biofactors. 2005;25:197
  20. Mancini A, De Marinis L, Oradei A, Hallgass ME, Conte G, Pozza D, et al. Coenzyme Q10 concentrations in normal and pathological human seminal fluid. J Androl. 1994;15:591
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  22. Safarinejad MR, Safarinejad S. Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. J Urol. 2009;181:741
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 Study received approval from the Urology and Nephrology Research Center human ethics committee.

PII: S0022-5347(09)00542-4

doi: 10.1016/j.juro.2009.02.121

The Journal of Urology
Volume 182, Issue 1 , Pages 237-248 , July 2009

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