The Journal of Urology
Volume 181, Issue 5 , Pages 2027-2032 , May 2009

Renal Sinus Fat Invasion in pT3a Clear Cell Renal Cell Carcinoma Affects Outcomes of Patients Without Nodal Involvement or Distant Metastases

  • Roberto Bertini

      Affiliations

    • Department of Urology, Vita-Salute University San Raffaele, Milan, Italy
    • ,
  • Marco Roscigno

      Affiliations

    • Department of Urology, Vita-Salute University San Raffaele, Milan, Italy
    • Corresponding Author InformationCorrespondence: Vita Salute University San Raffaele, Via Olgettina 60, 20132, Milan, Italy (telephone: +39-2-2643-4199; FAX: +39-2-26437298)
    • ,
  • Massimo Freschi

      Affiliations

    • Department of Pathology, Vita-Salute University San Raffaele, Milan, Italy
    • ,
  • Elena Strada

      Affiliations

    • Department of Urology, Vita-Salute University San Raffaele, Milan, Italy
    • ,
  • Giovanni Petralia

      Affiliations

    • Department of Urology, Vita-Salute University San Raffaele, Milan, Italy
    • ,
  • Alessandra Pasta

      Affiliations

    • Department of Urology, Vita-Salute University San Raffaele, Milan, Italy
    • ,
  • Rayan Matloob

      Affiliations

    • Department of Urology, Vita-Salute University San Raffaele, Milan, Italy
    • ,
  • Francesco Sozzi

      Affiliations

    • Department of Urology, Vita-Salute University San Raffaele, Milan, Italy
    • ,
  • Luigi Da Pozzo

      Affiliations

    • Department of Urology, Vita-Salute University San Raffaele, Milan, Italy
    • ,
  • Renzo Colombo

      Affiliations

    • Department of Urology, Vita-Salute University San Raffaele, Milan, Italy
    • ,
  • Giorgio Guazzoni

      Affiliations

    • Department of Urology, Vita-Salute University San Raffaele, Milan, Italy
    • ,
  • Claudio Doglioni

      Affiliations

    • Department of Pathology, Vita-Salute University San Raffaele, Milan, Italy
    • ,
  • Francesco Montorsi

      Affiliations

    • Department of Urology, Vita-Salute University San Raffaele, Milan, Italy
    • ,
  • Patrizio Rigatti

      Affiliations

    • Department of Urology, Vita-Salute University San Raffaele, Milan, Italy

Received 7 October 2008

References 

  1. Greene FL, Page DL, Fleming ID, Fritz AG, Balch CM, Haller DG, et al. AJCC Cancer Staging Manual. 6th ed.. New York: Springer-Verlag; 2002;
  2. Gospodarowicz MK, Miller D, Groome PA, Greene FL, Logan PA, Sobin LH. The process for continuous improvement of the TNM classification. Cancer. 2004;100:1
  3. Thompson RH, Leibovich BC, Cheville JC, Lohse CM, Frank I, Kwon ED, et al. Should ipsilateral adrenal invasion from renal cell carcinoma be classified as pT3a?. J Urol. 2005;173:918
  4. Ficarra V, Novara G, Iafrate M, Cappellaro L, Bratti E, Zattoni F, et al. Proposal for reclassification of the TNM staging system in patients with locally advanced (pT3–4) renal cell carcinoma according to the cancer-related outcome. Eur Urol. 2007;51:722
  5. Ficarra V, Galfano A, Guillè F, Schips L, Tostain J, Mejean A, et al. A new staging system for locally advanced (pT3–4) renal cell carcinoma: a multicenter European study including 2,000 patients. J Urol. 2007;178:418
  6. Bonsib SM, Gibson D, Mhoon M, Greene FG. Renal sinus involvement in renal cell carcinoma. Am J Surg Pathol. 2000;24:451
  7. Bonsib SM. The renal sinus is the principal invasive pathway: a prospective study of 100 renal cell carcinomas. Am J Surg Pathol. 2004;28:1594
  8. Bonsib SM. T2 clear cell renal cell carcinoma is a rare entity: a study of 120 clear cell renal cell carcinomas. J Urol. 2005;174:1199
  9. Thompson RH, Leibovich BC, Cheville JC, Webster WS, Lohse CM, Kwon ED, et al. Is renal sinus fat invasion the same as perinephric fat invasion for pT3a renal cell carcinoma?. J Urol. 2005;174:1218
  10. Margulis V, Tamboli P, Matin SF, Meisner M, Swanson DA, Wood CG. Location of extrarenal tumor extension does not impact survival of patients with pT3a renal cell carcinoma. J Urol. 2007;178:1878
  11. Kirkaly Z, Algaba F, Scarpelli M, Trias I, Selvaggi FP, Van Poppel H. What does the urologist expect from the pathologist (and what can the pathologists give) in reporting on adult kidney tumour specimens?. Eur Urol. 2007;51:1194
  12. Terrone C, Volpe A. The role of pathology for clinical decision-making in renal cell carcinoma is increasing. Eur Urol. 2007;51:1166
  13. Satyapal KS. Classification of the drainage patterns of the renal veins. J Anat. 1995;186:329
  14. Terrone C, Cracco C, Porpiglia F, Bollito E, Scoffone C, Poggio M, et al. Reassessing the current TNM lymph node staging for renal cell carcinoma. Eur Urol. 2006;49:324

 Study received ethical committee approval.

PII: S0022-5347(09)00070-6

doi: 10.1016/j.juro.2009.01.048

The Journal of Urology
Volume 181, Issue 5 , Pages 2027-2032 , May 2009

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