The Journal of Urology
Volume 181, Issue 5 , Pages 2009-2017 , May 2009

The Necessity of Adrenalectomy at the Time of Radical Nephrectomy: A Systematic Review

  • Rebecca L. O'Malley

      Affiliations

    • Nothing to disclose.
  • ,
  • Guilherme Godoy

      Affiliations

    • Supported by the Bruce and Cynthia Sherman Fellowship in Urologic Oncology.
  • ,
  • Jamie A. Kanofsky

      Affiliations

    • Nothing to disclose.
  • ,
  • Samir S. Taneja

      Affiliations

    • Corresponding Author InformationCorrespondence: Division of Urologic Oncology, Department of Urology, NYU Cancer Institute, New York University Langone Medical Center, 150 East 32nd St., Suite 200, New York, New York 10016 (telephone: 646-825-6321; FAX: 646-825-6399)
    • Financial interest and/or other relationship with GTX, Envisioneering Medical, Watson Pharmaceuticals, Ipsen, U.S. HIFU, Fujirebo and GlaxoSmithKline.

Received 13 August 2008

References 

  1. Robson CJ, Churchill BM, Anderson W. The results of radical nephrectomy for renal cell carcinoma. J Urol. 1969;101:297
  2. Kozlowski JM. Management of distant solitary recurrence in the patient with renal cancer (Contralateral kidney and other sites). Urol Clin North Am. 1994;21:601
  3. Skinner DG, Colvin RB, Vermillion CD, Pfister RC, Leadbetter WF. Diagnosis and management of renal cell carcinoma (A clinical and pathologic study of 309 cases). Cancer. 1971;28:1165
  4. Waters WB, Richie JP. Aggressive surgical approach to renal cell carcinoma: review of 130 cases. J Urol. 1979;122:306
  5. Jayson M, Sanders H. Increased incidence of serendipitously discovered renal cell carcinoma. Urology. 1998;51:203
  6. Pantuck AJ, Zisman A, Belldegrun AS. The changing natural history of renal cell carcinoma. J Urol. 2001;166:1611
  7. Lightfoot N, Conlon M, Kreiger N, Bissett R, Desai M, Warde P, et al. Impact of noninvasive imaging on increased incidental detection of renal cell carcinoma. Eur Urol. 2000;37:521
  8. Motzer RJ, Bander NH, Nanus DM. Renal-cell carcinoma. N Engl J Med. 1996;335:865
  9. Hellstrom PA, Bloigu R, Ruokonen AO, Vainionpaa VA, Nuutinen LS, Kontturi MJ. Is routine ipsilateral adrenalectomy during radical nephrectomy harmful for the patient?. Scand J Urol Nephrol. 1997;31:19
  10. Haber GP, Gill IS. Laparoscopic partial nephrectomy: contemporary technique and outcomes. Eur Urol. 2006;49:660
  11. Lane BR, Gill IS. 5-Year outcomes of laparoscopic partial nephrectomy. J Urol. 2007;177:70
  12. Mitchell RE, Gilbert SM, Murphy AM, Olsson CA, Benson MC, McKiernan JM. Partial nephrectomy and radical nephrectomy offer similar cancer outcomes in renal cortical tumors 4 cm or larger. Urology. 2006;67:260
  13. Allaf ME, Bhayani SB, Rogers C, Varkarakis I, Link RE, Inagaki T, et al. Laparoscopic partial nephrectomy: evaluation of long-term oncological outcome. J Urol. 2004;172:871
  14. Uzzo RG, Novick AC. Nephron sparing surgery for renal tumors: indications, techniques and outcomes. J Urol. 2001;166:6
  15. Gill IS, Remer EM, Hasan WA, Strzempkowski B, Spaliviero M, Steinberg AP, et al. Renal cryoablation: outcome at 3 years. J Urol. 2005;173:1903
  16. Blute ML. Editorial comment. Urol Oncol. 2006;24:556
  17. Fergany AF, Hafez KS, Novick AC. Long-term results of nephron sparing surgery for localized renal cell carcinoma: 10-year followup. J Urol. 2000;163:442
  18. Novick AC. Laparoscopic and partial nephrectomy. Clin Cancer Res. 2004;10:6322S
  19. Mickisch G, Carballido J, Hellsten S, Schulze H, Mensink Hand European Association of Urology. Guidelines on renal cell cancer. Eur Urol. 2001;40:252
  20. Wunderlich H, Schlichter A, Reichelt O, Zermann DH, Janitzky V, Kosmehl H, et al. Real indications for adrenalectomy in renal cell carcinoma. Eur Urol. 1999;35:272
  21. Tsui KH, Shvarts O, Barbaric Z, Figlin R, de Kernion JB, Belldegrun A. Is adrenalectomy a necessary component of radical nephrectomy? (UCLA experience with 511 radical nephrectomies). J Urol. 2000;163:437
  22. Antonelli A, Cozzoli A, Simeone C, Zani D, Zanotelli T, Portesi E, et al. Surgical treatment of adrenal metastasis from renal cell carcinoma: a single-centre experience of 45 patients. BJU Int. 2006;97:505
  23. Autorino R, Di Lorenzo G, Damiano R, Perdona S, Oliva A, D'Armiento M, et al. Adrenal sparing surgery in the treatment of renal cell carcinoma: when is it possible?. World J Urol. 2003;21:153
  24. De Sio M, Autorino R, Di Lorenzo G, Damiano R, Cosentino L, De Placido S, et al. Adrenalectomy: defining its role in the surgical treatment of renal cell carcinoma. Urol Int. 2003;71:361
  25. Gill IS, McClennan BL, Kerbl K, Carbone JM, Wick M, Clayman RV. Adrenal involvement from renal cell carcinoma: predictive value of computerized tomography. J Urol. 1994;152:1082
  26. Ito A, Satoh M, Ohyama C, Saito S, Shintaku I, Nakano O, et al. Adrenal metastasis from renal cell carcinoma: significance of adrenalectomy. Int J Urol. 2002;9:125
  27. Kletscher BA, Qian J, Bostwick DG, Blute ML, Zincke H. Prospective analysis of the incidence of ipsilateral adrenal metastasis in localized renal cell carcinoma. J Urol. 1996;155:1844
  28. Moudouni SM, En-Nia I, Patard JJ, Manunta A, Guille F, Lobel B. Real indications for adrenalectomy in renal cell carcinoma. Scand J Urol Nephrol. 2002;36:273
  29. Siemer S, Lehmann J, Kamradt J, Loch T, Remberger K, Humke U, et al. Adrenal metastases in 1,635 patients with renal cell carcinoma: outcome and indication for adrenalectomy. J Urol. 2004;171:2155
  30. Saitoh H, Hida M, Nakamura K, Shimbo T, Shiramizu T, Satoh T. Metastatic processes and a potential indication of treatment for metastatic lesions of renal adenocarcinoma. J Urol. 1982;128:916
  31. Kozak W, Holtl W, Pummer K, Maier U, Jeschke K, Bucher A. Adrenalectomy—still a must in radical renal surgery?. Br J Urol. 1996;77:27
  32. O'Brien WM, Lynch JH. Adrenal metastases by renal cell carcinoma (Incidence at nephrectomy). Urology. 1987;29:605
  33. Paul R, Mordhorst J, Leyh H, Hartung R. Incidence and outcome of patients with adrenal metastases of renal cell cancer. Urology. 2001;57:878
  34. Sagalowsky AI, Kadesky KT, Ewalt DM, Kennedy TJ. Factors influencing adrenal metastasis in renal cell carcinoma. J Urol. 1994;151:1181
  35. Winter P, Miersch WD, Vogel J, Jaeger N. On the necessity of adrenal extirpation combined with radical nephrectomy. J Urol. 1990;144:842
  36. Angervall L, Wahlqvist L. Follow-up and prognosis of renal carcinoma in a series operated by perifascial nephrectomy combined with adrenalectomy and retroperitoneal lymphadenectomy. Eur Urol. 1978;4:13
  37. Li GR, Soulie M, Escourrou G, Plante P, Pontonnier F. Micrometastatic adrenal invasion by renal carcinoma in patients undergoing nephrectomy. Br J Urol. 1996;78:826
  38. Kuczyk M, Wegener G, Jonas U. The therapeutic value of adrenalectomy in case of solitary metastatic spread originating from primary renal cell cancer. Eur Urol. 2005;48:252
  39. Leibovitch I, Raviv G, Mor Y, Nativ O, Goldwasser B. Reconsidering the necessity of ipsilateral adrenalectomy during radical nephrectomy for renal cell carcinoma. Urology. 1995;46:316
  40. Paul R, Mordhorst J, Busch R, Leyh H, Hartung R. Adrenal sparing surgery during radical nephrectomy in patients with renal cell cancer: a new algorithm. J Urol. 2001;166:59
  41. Shalev M, Cipolla B, Guille F, Staerman F, Lobel B. Is ipsilateral adrenalectomy a necessary component of radical nephrectomy?. J Urol. 1995;153:1415
  42. von Knobloch R, Seseke F, Riedmiller H, Grone HJ, Walthers EM, Kalble T. Radical nephrectomy for renal cell carcinoma: is adrenalectomy necessary?. Eur Urol. 1999;36:303
  43. Yokoyama H, Tanaka M. Incidence of adrenal involvement and assessing adrenal function in patients with renal cell carcinoma: is ipsilateral adrenalectomy indispensable during radical nephrectomy?. BJU Int. 2005;95:526
  44. Sandock DS, Seftel AD, Resnick MI. Adrenal metastases from renal cell carcinoma: role of ipsilateral adrenalectomy and definition of stage. Urology. 1997;49:28
  45. Kuczyk M, Munch T, Machtens S, Bokemeyer C, Wefer A, Hartmann J, et al. The need for routine adrenalectomy during surgical treatment for renal cell cancer: the Hannover experience. BJU Int. 2002;89:517
  46. Sawai Y, Kinouchi T, Mano M, Meguro N, Maeda O, Kuroda M, et al. Ipsilateral adrenal involvement from renal cell carcinoma: retrospective study of the predictive value of computed tomography. Urology. 2002;59:28
  47. Schwartz LH, Panicek DM, Doyle MV, Ginsberg MS, Herman SK, Koutcher JA, et al. Comparison of two algorithms and their associated charges when evaluating adrenal masses in patients with malignancies. AJR Am J Roentgenol. 1997;168:1575
  48. Lau WK, Zincke H, Lohse CM, Cheville JC, Weaver AL, Blute ML. Contralateral adrenal metastasis of renal cell carcinoma: treatment, outcome and a review. BJU Int. 2003;91:775
  49. Kessler OJ, Mukamel E, Weinstein R, Gayer E, Konichezky M, Servadio C. Metachronous renal cell carcinoma metastasis to the contralateral adrenal gland. Urology. 1998;51:539
  50. Schorr AB. Twenty percent incidence of adrenocortical insufficiency in metastatic hypernephroma. Clin Res. 1986;34:200A
  51. Robey EL, Schellhammer PF. The adrenal gland and renal cell carcinoma: is ipsilateral adrenalectomy a necessary component of radical nephrectomy?. J Urol. 1986;135:453
  52. Kobayashi T, Nakamura E, Yamamoto S, Kamoto T, Okuno H, Terai A, et al. Low incidence of ipsilateral adrenal involvement and recurrences in patients with renal cell carcinoma undergoing radical nephrectomy: a retrospective analysis of 393 patients. Urology. 2003;62:40
  53. Bazeed MA, Scharfe T, Becht E, Jurincic C, Alken P, Thuroff JW. Conservative surgery of renal cell carcinoma. Eur Urol. 1986;12:238
  54. Morgan WR, Zincke H. Progression and survival after renal-conserving surgery for renal cell carcinoma: experience in 104 patients and extended followup. J Urol. 1990;144:852
  55. Provet J, Tessler A, Brown J, Golimbu M, Bosniak M, Morales P. Partial nephrectomy for renal cell carcinoma: indications, results and implications. J Urol. 1991;145:472
  56. Jonasch E, Tannir NM. Adjuvant and neoadjuvant therapy in renal cell carcinoma. Cancer J. 2008;14:315

 Editor's Note: This article is the first of 5 published in this issue for which category 1 CME credits can be earned. Instructions for obtaining credits are given with the questions on pages 2392 and 2393.

PII: S0022-5347(09)00040-8

doi: 10.1016/j.juro.2009.01.018

The Journal of Urology
Volume 181, Issue 5 , Pages 2009-2017 , May 2009