The Journal of Urology
Volume 181, Issue 4 , Pages 1558-1564 , April 2009

Presence of Tumor Necrosis is Not a Significant Predictor of Survival in Clear Cell Renal Cell Carcinoma: Higher Prognostic Accuracy of Extent Based Rather Than Presence/Absence Classification

  • Tobias Klatte

      Affiliations

    • Department of Urology, University of California-Los Angeles, Los Angeles, California
    • ,
  • Jonathan W. Said

      Affiliations

    • Department of Pathology and Laboratory Medicine, University of California-Los Angeles, Los Angeles, California
    • ,
  • Michela de Martino

      Affiliations

    • Department of Urology, University of California-Los Angeles, Los Angeles, California
    • ,
  • Jeffrey LaRochelle

      Affiliations

    • Department of Urology, University of California-Los Angeles, Los Angeles, California
    • ,
  • Brian Shuch

      Affiliations

    • Department of Urology, University of California-Los Angeles, Los Angeles, California
    • ,
  • Jian Yu Rao

      Affiliations

    • Department of Pathology and Laboratory Medicine, University of California-Los Angeles, Los Angeles, California
    • ,
  • George V. Thomas

      Affiliations

    • Department of Pathology and Laboratory Medicine, University of California-Los Angeles, Los Angeles, California
    • ,
  • Fairooz F. Kabbinavar

      Affiliations

    • Department of Medicine, University of California-Los Angeles, Los Angeles, California
    • ,
  • Arie S. Belldegrun

      Affiliations

    • Department of Urology, University of California-Los Angeles, Los Angeles, California
    • ,
  • Allan J. Pantuck

      Affiliations

    • Department of Urology, University of California-Los Angeles, Los Angeles, California
    • Corresponding Author InformationCorrespondence: Department of Urology, David Geffen School of Medicine at UCLA, Room B7-298 CHS, Box 951738, Los Angeles, California 90095-1738 (telephone: 310-206-2436; FAX: 310-206-4082)

Received 11 August 2008

References 

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  2. Klatte T, Pantuck AJ, Kleid MD, Belldegrun AS. Understanding the natural biology of kidney cancer: implications for targeted cancer therapy. Rev Urol. 2007;9:47
  3. Lam JS, Shvarts O, Leppert JT, Pantuck AJ, Figlin RA, Belldegrun AS. Postoperative surveillance protocol for patients with localized and locally advanced renal cell carcinoma based on a validated prognostic nomogram and risk group stratification system. J Urol. 2005;174:466
  4. Lam JS, Leppert JT, Belldegrun AS, Figlin RA. Adjuvant therapy of renal cell carcinoma: patient selection and therapeutic options. BJU Int. 2005;96:483
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  7. Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 2007;356:115
  8. Lam JS, Shvarts O, Leppert JT, Figlin RA, Belldegrun AS. Renal cell carcinoma 2005: new frontiers in staging, prognostication and targeted molecular therapy. J Urol. 2005;173:1853
  9. Frank I, Blute ML, Cheville JC, Lohse CM, Weaver AL, Zincke H. An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: the SSIGN score. J Urol. 2002;168:2395
  10. Moch H, Gasser T, Amin MB, Torhorst J, Sauter G, Mihatsch MJ. Prognostic utility of the recently recommended histologic classification and revised TNM staging system of renal cell carcinoma: a Swiss experience with 588 tumors. Cancer. 2000;89:604
  11. Amin MB, Amin MB, Tamboli P, Javidan J, Stricker H, de-Peralta VM, et al. Prognostic impact of histologic subtyping of adult renal epithelial neoplasms: an experience of 405 cases. Am J Surg Pathol. 2002;26:281
  12. Zubac DP, Bostad L, Gestblom C, Kihl B, Seidal T, Wentzel-Larsen T, et al. Renal cell carcinoma: a clinicopathological follow-up study after radical nephrectomy. Scand J Urol Nephrol. 2007;41:191
  13. Sengupta S, Lohse CM, Leibovich BC, Frank I, Thompson RH, Webster WS, et al. Histologic coagulative tumor necrosis as a prognostic indicator of renal cell carcinoma aggressiveness. Cancer. 2005;104:511
  14. Delahunt B, Nacey JN. Renal cell carcinoma (II. Histological indicators of prognosis). Pathology. 1987;19:258
  15. Lam JS, Shvarts O, Said JW, Pantuck AJ, Seligson DB, Aldridge ME, et al. Clinicopathologic and molecular correlations of necrosis in the primary tumor of patients with renal cell carcinoma. Cancer. 2005;103:2517
  16. Leibovitch I, Lev R, Mor Y, Golomb J, Dotan ZA, Ramon J. Extensive necrosis in renal cell carcinoma specimens: potential clinical and prognostic implications. Isr Med Assoc J. 2001;3:563
  17. Trinh QD, Karakiewicz PI, Antebi E, Lewinshtein D, Abbou CC, Salomon L, et al. The presence of tumor necrosis within the primary tumor cannot independently predict renal cell carcinoma-specific mortality after nephrectomy. J Urol. 2007;177(suppl.):410;abstract 1245
  18. Brinker DA, Amin MB, de Peralta-Venturina M, Reuter V, Chan DY, Epstein JI. Extensively necrotic cystic renal cell carcinoma: a clinicopathologic study with comparison to other cystic and necrotic renal cancers. Am J Surg Pathol. 2000;24:988
  19. Amtrup F, Hansen JB, Thybo E. Prognosis in renal carcinoma evaluated from histological criteria. Scand J Urol Nephrol. 1974;8:198
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 Study received institutional review board approval.

PII: S0022-5347(08)03261-8

doi: 10.1016/j.juro.2008.11.098

The Journal of Urology
Volume 181, Issue 4 , Pages 1558-1564 , April 2009

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