The Journal of Urology
Volume 181, Issue 4 , Pages 1913-1921 , April 2009

Peroxisome Proliferator Activated Receptor β/δ Activation Prevents Extracellular Regulated Kinase 1/2 Phosphorylation and Protects the Testis From Ischemia and Reperfusion Injury

  • Letteria Minutoli

      Affiliations

    • Departments of Clinical and Experimental Medicine and Pharmacology (Section of Pharmacology), University of Messina, Messina, Italy
    • ,
  • Pietro Antonuccio

      Affiliations

    • Department of Medical and Surgical Pediatric Sciences, University of Messina, Messina, Italy
    • ,
  • Francesca Polito

      Affiliations

    • Departments of Clinical and Experimental Medicine and Pharmacology (Section of Pharmacology), University of Messina, Messina, Italy
    • ,
  • Alessandra Bitto

      Affiliations

    • Departments of Clinical and Experimental Medicine and Pharmacology (Section of Pharmacology), University of Messina, Messina, Italy
    • ,
  • Francesco Squadrito

      Affiliations

    • Departments of Clinical and Experimental Medicine and Pharmacology (Section of Pharmacology), University of Messina, Messina, Italy
    • Corresponding Author InformationCorrespondence: Section of Pharmacology, Department of Experimental and Clinical Medicine and Pharmacology, Torre Biologica, 5th floor, AOU Policlinico “G. Martino,” Via C. Valeria Gazzi, 98125 Messina, Italy (telephone: +39 090 2213648; FAX: +39 090 2213300)
    • ,
  • Natasha Irrera

      Affiliations

    • Departments of Clinical and Experimental Medicine and Pharmacology (Section of Pharmacology), University of Messina, Messina, Italy
    • ,
  • Piero Antonio Nicotina

      Affiliations

    • Department of Human Pathology, University of Messina, Messina, Italy
    • ,
  • Carmine Fazzari

      Affiliations

    • Department of Human Pathology, University of Messina, Messina, Italy
    • ,
  • Angela Simona Montalto

      Affiliations

    • Department of Medical and Surgical Pediatric Sciences, University of Messina, Messina, Italy
    • ,
  • Vincenzo Di Stefano

      Affiliations

    • Departments of Clinical and Experimental Medicine and Pharmacology (Section of Pharmacology), University of Messina, Messina, Italy
    • ,
  • Carmelo Romeo

      Affiliations

    • Department of Medical and Surgical Pediatric Sciences, University of Messina, Messina, Italy
    • ,
  • Domenica Altavilla

      Affiliations

    • Departments of Clinical and Experimental Medicine and Pharmacology (Section of Pharmacology), University of Messina, Messina, Italy

Received 6 October 2008

References 

  1. Ringdahl E, Teague L. Testicular torsion. Am Fam Physician. 2006;74:1739
  2. Filho DW, Torres MA, Bordin AL, Crezcynski-Pasa TB, Boveris A. Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury. Mol Aspects Med. 2004;25:199
  3. Lysiak JJ. The role of tumor necrosis factor-alpha and interleukin-1 in the mammalian testis and their involvement in testicular torsion and autoimmune orchitis. Reprod Biol Endocrinol. 2004;10:9
  4. Spierings DC, de Vries EG, Vellenga E, van den Heuvel FA, Koornstra JJ, Wesseling J, et al. Tissue distribution of the death ligand TRAIL and its receptors. J Histochem Cytochem. 2004;52:821
  5. Zoja C, Wang JM, Bettoni S, Sironi M, Renzi D, ChiaVarino F, et al. Interleukin-1 beta and tumor necrosis factor-alpha induce gene expression and production of leukocyte chemotactic factors, colony-stimulating factors, and interleukin-6 in human mesangial cells. Am J Pathol. 1991;138:991
  6. Grataroli R, Vindrieux D, Gougeon A, Benahmed M. Expression of tumor necrosis factor-alpha-related apoptosis inducing ligand and its receptors in rat testis during development. Biol Reprod. 2002;66:1707
  7. Rival C, Theas MS, Guazzone VA, Lustig L. Interleukin-6 and IL-6 receptor cell expression in testis of rats with autoimmune orchitis. J Reprod Immunol. 2006;70:43
  8. Minutoli L, Antonuccio P, Romeo C, Nicotina PA, Bitto A, Arena S, et al. Evidence for a role of mitogen-activated protein kinase 3/mitogen-activated protein kinase in the development of testicular ischemia-reperfusion injury. Biol Reprod. 2005;73:730
  9. Antonuccio P, Minutoli L, Romeo C, Nicòtina PA, Bitt A, Arena S, et al. Lipid peroxidation activates mitogen-activated protein kinases in testicular ischemia-reperfusion injury. J Urol. 2006;176:1666
  10. Youssef J, Badr M. Peroxisome proliferators-activated receptors: from orphanage to fame in a decade. Saudi Pharm J. 2002;9:1
  11. Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev. 1999;20:649
  12. Braissant O, Foufelle F, Scotto C, Dauca M, Wahli W. Differential expression of peroxisome proliferator- activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and gamma in the adult rat. Endocrinology. 1996;137:354
  13. Lee CH, Chawla A, Urbiztondo N, Liao D, Boisvert WA, Karin M, et al. Transcriptional repression of atherogenic inflammation: modulation by PPARδ. Science. 2003;302:453
  14. Welch JS, Ricote M, Akiyama TE, Gonzales FJ, Glass CK. PPARγ and PPARδ negatively regulate specific subsets of lipopolysaccharide and IFN-γ target gene in macrophage. Proc Natl Acad Sci U S A. 2003;100:6712
  15. Kino T, Rice KC, Chrousos GP. The PPARδ agonist GW501516 suppresses interleukin-6-mediated hepatocyte acute phase reaction via STAT3 inhibition. Eur J Clin Invest. 2007;37:425
  16. Greenstein A, Schreiber L, Matzkin H. The effect of methylene blue on histological damage after spermatic cord torsion in a rat model. BJU Int. 2001;88:90
  17. Burns KA, Vanden Heuvel JP. Modulation of PPAR activity via phosphorylation. Biochim Biophys Acta. 2007;1771:952
  18. Inan M, Basaran U, Dokmeci D, Knter M, Yalcin O, Aydogdu N, et al. Rosiglitazone (An agonist of peroxisome proliferator-activated receptor-gamma, prevents contralateral testicular ischemia-reperfusion injury in prepubertal rats). Clin Exp Pharmacol Physiol. 2007;34:457
  19. Chinetti G, Fruchart JC, Staels B. Peroxisome proliferator-activated receptors: new targets for the pharmacological modulation of macrophage gene expression and function. Curr Opin Lipidol. 2003;14:459
  20. Rodríguez-Calvo R, Serrano L, Coll T, Moullan N, Sánchez RM, Merlos M, et al. Activation of peroxisome proliferator-activated receptor beta/delta inhibits lipopolysaccharide-induced cytokine production in adipocytes by lowering nuclear factor-kappaB activity via extracellular signal-related kinase 1/2. Diabetes. 2008;57:2149

 Study received institutional review board approval.

PII: S0022-5347(08)03258-8

doi: 10.1016/j.juro.2008.11.095

The Journal of Urology
Volume 181, Issue 4 , Pages 1913-1921 , April 2009

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