The Journal of Urology
Volume 181, Issue 3 , Pages 1381-1386 , March 2009

Preventing Bladder Tumor Implantation With Photodynamic Therapy in a Rat Model Mimicking Post-Fluorescence Guided Transurethral Resection

Received 23 June 2008

References 

  1. Denzinger S, Wieland WF, Otto W, Knuechel R, Burger M. Does photodynamic transurethral resection of bladder tumour improve the outcome of initial T1 high-grade bladder cancer? (A long-term follow-up of a randomized study). BJU Int. 2008;101:566
  2. Denzainger S, Burger M, Walter B, Knuechel R, Wieland WF, Filbeck T. Clinically relevant reduction in risk of recurrence of superficial bladder cancer using 5-aminolevulinic acid-induced fluorescence diagnosis: 8-year results of prospective randomized study. Urology. 2007;69:675
  3. Boyd PJ, Burnand KG. Site of bladder-tumour recurrence. Lancet. 1974;2:1290
  4. Pinthus JH, Bogaards A, Weersink R, Wilson BC, Trachtenberg J. Photodynamic therapy for urological malignancies: past to current approaches. J Urol. 2006;175:1201
  5. Waidelich R, Beyer W, Knuechel R, Stepp H, Baumgartner R, Schroder J, et al. Whole bladder photodynamic therapy with 5-aminolevulinic acid using a white light source. Urology. 2003;61:332
  6. El Khatib S, Berrahmoune S, Leroux A, Bezdetnaya L, Guillemin F, D'Hallewin MA. Novel orthotopic bladder tumor model with predictable localization of a solitary tumor. Cancer Biol Ther. 2006;5:1327
  7. Xiao Z, McCallum TJ, Brown KM, Miller GG, Halls SB, Parney I, et al. Characterization of a novel transplantable orthotopic rat bladder transitional cell tumour model. Br J Cancer. 1999;81:638
  8. El Khatib S, Didelon J, Leroux A, Notter D, D'Hallewin M. Kinetics, biodistribution and therapeutic efficacy of hexylester 5-aminolevulinate induced photodynamic therapy in an orthotopic rat bladder tumor model. J Urol. 2004;172:2013
  9. Hafner C, Knuechel R, Zanardo L, Dietmaier W, Blaszyk H, Cheville J, et al. Evidence for oligoclonality and tumor spread by intraluminal seeding in multifocal urothelial carcinomas of the upper and lower urinary tract. Oncogene. 2001;20:4910
  10. Berrahmoune S, Fotinos N, Bezdetnaya L, Lange N, Guedenet JC, Guillemin F, et al. Analysis of differential PDT effect in rat bladder tumor models according to concentration of intravesical hexyl-aminolevulinate. Photochem Photobiol Sci. 2008;7:1018
  11. Brocks CP, Büttner H, Böhle A. Inhibition of tumor implantation by intravesical gemcitabine in a murine model of superficial bladder cancer. J Urol. 2005;174:1115
  12. Sindhwani P, Hampton JA, Baig MM, Keck R, Selman SH. Curcumin prevents intravesical tumor implantation of the MBT-2 tumor cell line in C3H mice. J Urol. 2001;166:1498
  13. Oosterlinck W, Kurth KH, Schröder F, Bultinck J, Hammond B, Sylvester R. A prospective European Organization for Research and Treatment of Cancer Genitourinary Group randomized trial comparing transurethral resection followed by a single intravesical instillation of epirubicin or water in single stage Ta, T1 papillary carcinoma of the bladder. J Urol. 1993;149:749
  14. Spörri S, Chopra V, Egger N, Hawkins HK, Motamedi M, Dreher E, et al. Effects of 5-aminolaevulinic acid on human ovarian cancer cells and human vascular endothelial cells in vitro. J Photochem Photobiol B. 2001;64:8
  15. Shapiro A, Kelley DR, Oakley DM, Catalona WJ, Ratliff TL. Technical factors affecting the reproducibility of intravesical mouse bladder tumor implantation during therapy with bacillus Calmette-Guérin. Cancer Res. 1984;44:3051
  16. Günther JH, Jurczok A, Wulf T, Brandau S, Deinert I, Jocham D, et al. Optimizing syngeneic orthotopic murine bladder cancer (MB49). Cancer Res. 1999;59:2834
  17. Kamuhabwa AA, Roskams T, D'Hallewin MA, Baert L, Van Poppel et al: Whole bladder wall photodynamic therapy of transitional cell carcinoma rat bladder tumors using intravesically administered hypericin. Int J Cancer 2003; 107: 460.Kamuhabwa AA, Roskams T, D'Hallewin MA, Baert L, Van Poppel , et al. Whole bladder wall photodynamic therapy of transitional cell carcinoma rat bladder tumors using intravesically administered hypericin. Int J Cancer. 2003;107:460
  18. Kemberling JK, Hampton JA, Keck RW, Gomez MA, Selman SH. Inhibition of bladder tumor growth by the green tea derivative epigallocatechin-3-gallate. J Urol. 2003;170:773
  19. D'Hallewin MA, De Witte P, Waelkens E, Merlevede W, Baert L. Fluorescence detection of flat bladder carcinoma in situ after intravesical instillation of hypericin. J Urol. 2000;164:349
  20. Battah S, Balaratnam S, Casas A, O'Neill S, Edwards C, Batlle A, et al. Macromolecular delivery of 5-aminolaevulinic acid for photodynamic therapy using dendrimer conjugates. Mol Cancer Ther. 2007;6:876

 Study received institutional review board approval.

 Supported by the French Ligue Contre le Cancer (Meurthe et Moselle).

PII: S0022-5347(08)02988-1

doi: 10.1016/j.juro.2008.10.144

The Journal of Urology
Volume 181, Issue 3 , Pages 1381-1386 , March 2009