The Journal of Urology
Volume 181, Issue 1 , Pages 198-203 , January 2009

Investigation of Urodynamic Characteristics and Bladder Sensory Function in the Early Stages of Diabetic Bladder Dysfunction in Women With Type 2 Diabetes

  • Wei-Chia Lee

      Affiliations

    • Division of Urology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Kaohsiung, Taiwan
    • College of Medicine, Chang Gung University, Taoyuan, Taiwan
    • Graduate Institution of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    • ,
  • Huey-Peir Wu

      Affiliations

    • Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    • ,
  • Tong-Yuan Tai

      Affiliations

    • Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    • ,
  • Hong-Jeng Yu

      Affiliations

    • Department of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    • Corresponding Author InformationCorrespondence and requests for reprints: Department of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, 7 Chungshan South Rd., Taipei, Taiwan, 100 (telephone: 011-886-2-23562135; FAX: 011-886-2-23219145)
    • ,
  • Po-Hui Chiang

      Affiliations

    • Division of Urology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Kaohsiung, Taiwan
    • College of Medicine, Chang Gung University, Taoyuan, Taiwan

Received 5 April 2008

References 

  1. Wein AJ. Lower urinary tract dysfunction in neurological imaging and disease. In:  Wein AJ,  Kavoussi LR,  Novik AC,  Partin AW,  Peters CA editor. Campbell-Walsh Urology. 9th ed.. Philadephia: WB Saunders Co; 2007;p. 2011–2045
  2. Ellenberg M. Development of urinary bladder dysfunction in diabetes mellitus. Ann Intern Med. 1980;92:321
  3. Yu HJ, Lee WC, Liu SP, Tai TY, Wu HP, Chen J. Unrecognized voiding difficulty in female type 2 diabetic patients in the diabetes clinic: a prospective case-control study. Diabetes Care. 2004;27:988
  4. Ukimura O, Ushijima S, Honjo H, Iwata T, Suzuki K, Hirahara N, et al. Neuroselective current perception threshold evaluation of bladder mucosal sensory function. Eur Urol. 2004;45:70
  5. Szabo L, Barkai L, Lombay B. Urinary flow disturbance as an early sign of autonomic neuropathy in diabetic children and adolescents. Neurourol Urodyn. 2007;26:218
  6. Lee WC, Wu CC, Wu HP, Tai TY. Lower urinary tract symptoms and uroflowmetry in women with type 2 diabetes mellitus with and without bladder dysfunction. Urology. 2007;69:685
  7. American Diabetes Association. Standards of medical care in diabetes-2008. Diabetes Care. 2008;31:S12
  8. Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, et al. The standardisation of terminology in lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. Urology. 2003;61:37
  9. Abrams P. Bladder outlet obstruction index, bladder contractility index and bladder voiding efficiency: three simple indices to define bladder voiding function. BJU Int. 1999;84:14
  10. Heesakkers JP, Vriesema JL. The role of urodynamics in the treatment of lower urinary tract symptoms in women. Curr Opin Urol. 2005;15:215
  11. Yoshimura N, Chancellor MB, Andersson KE, Christ GJ. Recent advances in understanding the biology of diabetes-associated bladder complications and novel therapy. BJU Int. 2005;95:733
  12. Andersson KE. Antimuscarinics for treatment of overactive bladder. Lancet Neurol. 2004;3:46
  13. Sasaki K, Chancellor MB, Goins WF, Phelan MW, Glorioso JC, de Groat WC, et al. Gene therapy using replication-defective herpes simplex virus vectors expressing nerve growth factor in a rat model of diabetic cystopathy. Diabetes. 2004;53:2723
  14. Lee WC, Wu HP, Tai TY, Liu SP, Chen J, Yu HJ. Effects of diabetes on female voiding behavior. J Urol. 2004;172:989
  15. Cockayne DA, Hamilton SG, Zhu QM, Dunn PM, Zhong Y, Novakovic S, et al. Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature. 2000;407:1011
  16. Rapidi CA, Karandreas N, Katsifotis C, Benroubi M, Petropoulou K, Theodorou C. A combined urodynamic and electrophysiological study of diabetic cystopathy. Neurourol Urodyn. 2006;25:32
  17. Yamaguchi C, Sakakibara R, Uchiyama T, Yamamoto T, Ito T, Liu Z, et al. Overactive bladder in diabetes: a peripheral or central mechanism?. Neurourol Urodyn. 2007;26:807
  18. Esteghamati A, Rashidi A, Nikfallah A, Yousefizadeh A. The association between urodynamic findings and microvascular complications in patients with long-term type 2 diabetes but without voiding symptoms. Diabetes Res Clin Pract. 2007;78:42
  19. Rohrmann S, Smit E, Giovannucci E, Platz EA. Association between markers of the metabolic syndrome and lower urinary tract symptoms in the Third National Health and Nutrition Examination Survey (NHANES III). Int J Obes (Lond). 2005;29:310
  20. Lee WC, Chien CT, Yu HJ, Lee SW. Bladder dysfunction in rats with metabolic syndrome induced by long-term fructose feeding. J Urol. 2008;179:2470
  21. Ouslander JG. Management of overactive bladder. N Engl J Med. 2004;350:78

 Supported by BMRP 988 from Chang Gung Memorial Hospital.

 Study received Research Ethics Committee approval, National Taiwan University Hospital.

 See Editorial on page 13.For another article on a related topic see page 379.

PII: S0022-5347(08)02439-7

doi: 10.1016/j.juro.2008.09.021

The Journal of Urology
Volume 181, Issue 1 , Pages 198-203 , January 2009

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