The Journal of Urology
Volume 181, Issue 1 , Pages 128-132 , January 2009

Effectiveness of Antibiotics Given to Asymptomatic Men for an Increased Prostate Specific Antigen

  • Sümer Baltacı

      Affiliations

    • Department of Urology, University of Ankara, Faculty of Medicine, Turkey
    • ,
  • Evren Süer

      Affiliations

    • Department of Urology, University of Ankara, Faculty of Medicine, Turkey
    • Corresponding Author InformationCorrespondence: Kelebek Sokak 4/5 GOP Ankara, Turkey (telephone: 0090 +312 4450016; FAX: 0090 +312 4450017)
    • ,
  • Ahmet Hakan Haliloğlu

      Affiliations

    • Department of Urology, University of Ufuk, Faculty of Medicine, Ankara, Turkey
    • ,
  • Mehmet İlker Gokce

      Affiliations

    • Department of Urology, University of Ankara, Faculty of Medicine, Turkey
    • ,
  • Atilla Halil Elhan

      Affiliations

    • Department of Biostatistics, University of Ankara, Faculty of Medicine, Turkey
    • ,
  • Yaşar Bedük

      Affiliations

    • Department of Urology, University of Ankara, Faculty of Medicine, Turkey

Received 23 April 2008

References 

  1. Tchetgen MB, Oesterling JE. The effect of prostatitis, urinary retention, ejaculation, and ambulation on the serum prostate-specific antigen concentration. Urol Clin North Am. 1997;24:283
  2. Raaijmakers R, Wildhagen MF, Ito K, Pàez A, de Vries SH, Roobol MJ, et al. Prostate-specific antigen change in the European Randomized Study of Screening for Prostate Cancer, section Rotterdam. Urology. 2004;63:316
  3. Karazanashvili G, Managadze L. Prostate-specific antigen (PSA) value change after antibacterial therapy of prostate inflammation, as a diagnostic method for prostate cancer screening in cases of PSA value within 4-10 ng/ml and nonsuspicious results of digital rectal examination. Eur Urol. 2001;39:538
  4. Bozeman CB, Carver BS, Eastham JA, Venable DD. Treatment of chronic prostatitis lowers serum prostate specific antigen. J Urol. 2002;167:1723
  5. Schaeffer AJ, Wu SC, Tennenberg AM, Kahn JB. Treatment of chronic bacterial prostatitis with levofloxacin and ciprofloxacin lowers serum prostate specific antigen. J Urol. 2005;174:161
  6. Thompson IM, Pauler DK, Goodman PJ, Tangen CM, Lucia MS, Parnes HL, et al. Prevalence of prostate cancer among men with a prostate-specific antigen level < or =4.0 ng per milliliter. N Engl J Med. 2004;350:2239
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  8. Kwak C, Ku JH, Kim T, Park DW, Choi KY, Lee E, et al. Effect of subclinical prostatic inflammation on serum PSA levels in men with clinically undetectable prostate cancer. Urology. 2003;62:854
  9. Scardino PT. The responsible use of antibiotics for an elevated PSA level. Nat Clin Pract Urol. 2007;4:1
  10. Kaygisiz O, Uǧurlu O, Koşan M, Inal G, Oztürk B, Cetinkaya M. Effects of antibacterial therapy on PSA change in the presence and absence of prostatic inflammation in patients with PSA levels between 4 and 10 ng/ml. Prostate Cancer Prostatic Dis. 2006;9:235
  11. Jung K, Stephan C, Lein M, Henke W, Schnorr D, Brux B, et al. Analytical performance and clinical validity of two free prostate-specific antigen assays compared. Clin Chem. 1996;42:1026
  12. Terris MK, Stamey TA. Determination of prostate volume by transrectal ultrasound. J Urol. 1991;145:984
  13. Nadler RB, Collins MM, Propert KJ, Mikolajczyk SD, Knauss JS, Landis JR. Prostate-specific antigen test in diagnostic evaluation of chronic prostatitis/chronic pelvic pain syndrome. Urology. 2006;67:337
  14. Zhang L, Loblaw A, Klotz L. Modeling prostate specific antigen kinetics in patients on active surveillance. J Urol. 2006;176:1392
  15. Komatsu K, Wehner N, Prestigiacomo AF, Chen Z, Stamey TA. Physiologic (intraindividual) variation of serum prostate-specific antigen in 814 men from a screening population. Urology. 1996;47:343
  16. Kobayashi M, Nukui A, Morita T. Serum PSA and percent free PSA value changes after antibiotic treatment (A diagnostic method in prostate cancer suspects with asymptomatic prostatitis). Urol Int. 2008;80:186
  17. Jung K, Meyer A, Lein M, Rudolph B, Schnorr D, Loening SA. Ratio of free-to-total prostate specific antigen in serum cannot distinguish patients with prostate cancer from those with chronic inflammation of the prostate. J Urol. 1998;159:1595

 Nothing to disclose.

 Editor's Note: This article is the second of 5 published in this issue for which category 1 CME credits can be earned. Instructions for obtaining credits are given with the questions on pages 424 and 425.

PII: S0022-5347(08)02438-5

doi: 10.1016/j.juro.2008.09.020

The Journal of Urology
Volume 181, Issue 1 , Pages 128-132 , January 2009

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