The Journal of Urology
Volume 181, Issue 1 , Pages 193-197 , January 2009

Type 2 Diabetes Mellitus and Risk of Stress, Urge and Mixed Urinary Incontinence

  • Kim N. Danforth

      Affiliations

    • Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • ,
  • Mary K. Townsend

      Affiliations

    • Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
    • Corresponding Author InformationCorrespondence: Channing Laboratory, 181 Longwood Ave., Boston, Massachusetts 02115 (telephone: 617-525-2764; FAX: 617-525-2008)
    • Supported by the Yerby Postdoctoral Fellowship Program.
    • ,
  • Gary C. Curhan

      Affiliations

    • Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
    • Financial interest and/or other relationship with TAP Pharmaceuticals and Astellas.
    • ,
  • Neil M. Resnick

      Affiliations

    • Division of Geriatric Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
    • ,
  • Francine Grodstein

      Affiliations

    • Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts

Received 29 April 2008

References 

  1. Centers for Disease Control and Prevention: National Diabetes Surveillance System. http://www.cdc.gov/diabetes/statistics/prev/national/tprevfemage.htmAccessed April 4, 2008
  2. Hunskaar S, Arnold EP, Burgio K, Diokno AC, Herzog AR, Mallett VT. Epidemiology and natural history of urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct. 2000;11:301
  3. Brown JS, Seeley DG, Fong J, Black DM, Ensrud KE, Grady D. Urinary incontinence in older women: who is at risk? (Study of Osteoporotic Fractures Research Group). Obstet Gynecol. 1996;87:715
  4. Sampselle CM, Harlow SD, Skurnick J, Brubaker L, Bondarenko I. Urinary incontinence predictors and life impact in ethnically diverse perimenopausal women. Obstet Gynecol. 2002;100:1230
  5. Lifford KL, Curhan GC, Hu FB, Barbieri RL, Grodstein F. Type 2 diabetes mellitus and risk of developing urinary incontinence. J Am Geriatr Soc. 2005;53:1851
  6. Waetjen LE, Liao S, Johnson WO, Sampselle CM, Sternfield B, Harlow SD, et al. Factors associated with prevalent and incident urinary incontinence in a cohort of midlife women: a longitudinal analysis of data: study of women's health across the nation. Am J Epidemiol. 2007;165:309
  7. Nygaard IE, Lemke JH. Urinary incontinence in rural older women: prevalence, incidence and remission. J Am Geriatr Soc. 1996;44:1049
  8. Diokno A, Yuhico M. Preference, compliance and initial outcome of therapeutic options chosen by female patients with urinary incontinence. J Urol. 1995;154:1727
  9. Manson JE, Rimm EB, Stampfer MJ, Colditz GA, Willett WC, Krolewski AS, et al. Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet. 1991;338:774
  10. Field AE, Coakley EH, Must A, Spadano JL, Laird N, Dietz WH, et al. Impact of overweight on the risk of developing common chronic diseases during a 10-year period. Arch Intern Med. 2001;161:1581
  11. Ebbesen MH, Hannestad YS, Midthjell K, Hunskaar S. Diabetes and urinary incontinence-prevalence data from Norway. Acta Obstet Gynecol Scand. 2007;86:1256
  12. Brown JS, Grady D, Ouslander JG, Herzog AR, Varner RE, Posner SF. Prevalence of urinary incontinence and associated risk factors in postmenopausal women (Heart & Estrogen/Progestin Replacement Study (HERS) Research Group). Obstet Gynecol. 1999;94:66
  13. McGrother CW, Donaldson MM, Hayward T, Matthews R, Dallosso HM, Hyde C. Urinary storage symptoms and comorbidities: a prospective population cohort study in middle-aged and older women. Age Ageing. 2006;35:16
  14. Brown JS, Vittinghoff E, Lin F, Nyberg LM, Kusek JW, Kanaya AM. Prevalence and risk factors for urinary incontinence in women with type 2 diabetes and impaired fasting glucose: findings from the National Health and Nutrition Examination Survey (NHANES) 2001-2002. Diabetes Care. 2006;29:1307
  15. Rizk DE, Padmanabhan RK, Tariq S, Shafiullah M, Ahmed I. Ultra-structural morphological abnormalities of the urinary bladder in streptozotocin-induced diabetic female rats. Int Urogynecol J Pelvic Floor Dysfunct. 2006;17:143
  16. Stevens LA, Sellers DJ, McKay NG, Chapple CR, Chess-Williams R. Muscarinic receptor function, density and G-protein coupling in the overactive diabetic rat bladder. Auton Autacoid Pharmacol. 2006;26:303
  17. Diokno AC, Brown MB, Brock BM, Herzog AR, Normolle DP. Clinical and cystometric characteristics of continent and incontinent noninstitutionalized elderly. J Urol. 1988;140:567
  18. Sandvik H, Hunskaar S, Vanvik A, Bratt H, Seim A, Hermstad R. Diagnostic classification of female urinary incontinence: an epidemiological survey corrected for validity. J Clin Epidemiol. 1995;48:339
  19. Rothman KJ, Greenland S. Precision and validity in epidemiologic studies. In: Modern Epidemiology. Philadelphia: Lippincott Williams & Wilkins; 1998;p. 115–134chapt 8
  20. Townsend MK, Danforth KN, Lifford KL, Rosner B, Curhan GC, Resnick NM, et al. Incidence and remission of urinary incontinence in middle-aged women. Am J Obstet Gynecol. 2007;197:167

 Supported by National Institutes of Health Grants DK62438, CA87969 and CA50385.

 Study received institutional review board approval.

 See Editorial on page 13.

PII: S0022-5347(08)02425-7

doi: 10.1016/j.juro.2008.09.007

The Journal of Urology
Volume 181, Issue 1 , Pages 193-197 , January 2009

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