The Journal of Urology
Volume 181, Issue 1 , Pages 397-400 , January 2009

Pubo-Urethral Ligament Injury Causes Long-Term Stress Urinary Incontinence in Female Rats: An Animal Model of the Integral Theory

  • John C. Kefer

      Affiliations

    • Glickman Urological Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Guiming Liu

      Affiliations

    • Department of Urology and Female Pelvic Surgery, State University of New York, Upstate Medical University, Syracuse, New York
    • Glickman Urological Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Firouz Daneshgari

      Affiliations

    • Department of Urology and Female Pelvic Surgery, State University of New York, Upstate Medical University, Syracuse, New York
    • Glickman Urological Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio
    • Corresponding Author InformationCorrespondence: Department of Urology and Female Pelvic Surgery, Upstate Medical University, 750 East Adams St., Syracuse, New York 13210 (telephone: 315-464-4473)

Received 8 April 2008

References 

  1. Diokno AC, Burgio K, Fultz H, Kinchen KH, Obenchain R, Bump RC. Prevalence and outcomes of continence surgery in community dwelling women. J Urol. 2003;170:507
  2. Leach GE, Dmochowski RR, Appell RA, Blaivas JG, Hadley HR, Luber KM, et al. Female Stress Urinary Incontinence Clinical Guidelines Panel summary report on surgical management of female stress urinary incontinence. J Urol. 1997;158:875
  3. Petros PE. The pubourethral ligaments-an anatomical and histological study in the live patient. Int Urogynecol J Pelvic Floor Dysfunct. 1998;9:154
  4. Petros PE, Ulmsten UI. An integral theory of female urinary incontinence (Experimental and clinical considerations). Acta Obstet Gynecol Scand. 1990;153(suppl.):7
  5. Kefer J, Liu G, Daneshgari F. Pubo-urethral ligament injury causes stress urinary incontinence in the female rat. J Urol. 2008;179:775
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  10. Cannon TW, Wojcik EM, Ferguson CL, Saraga S, Thomas C, Damaser MS. Effects of vaginal distension on urethral anatomy and function. BJU Int. 2002;90:403
  11. Rodrıguez LV, Chen S, Jack GS, Almeida F, Lee KW, Zhang R. New objective measures to quantify stress urinary incontinence in a novel durable animal model of intrinsic sphincter deficiency. Am J Physiol Regul Integr Comp Physiol. 2005;288:R1332
  12. Cannon TW, Sweeney DD, Conway DA, Kamo I, Yoshimura N, Sacks M, et al. A tissue-engineered suburethral sling in an animal model of stress urinary incontinence. BJU Int. 2005;96:664
  13. Conway DA, Kamo I, Yoshimura N, Chancellor MB, Cannon TW. Comparison of leak point pressure methods in an animal model of stress urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct. 2005;16:359
  14. Lin AS, Carrier S, Morgan DM, Lue TF. Effect of simulated birth trauma on the urinary continence mechanism in the rat. Urology. 1998;52:143
  15. Allen RE, Hosker GL, Smith AR, Warrell DW. Pelvic floor damage and childbirth: a neurophysiological study. Br J Obstet Gynaecol. 1990;97:770
  16. Lukacz ES, Lawrence JM, Contreras R, Nager CW, Luber KM. Parity, mode of delivery, and pelvic floor disorders. Obstet Gynecol. 2006;107:1253
  17. Nilsson CG, Kuuva N, Falconer C, Rezapour M, Ulmsten U. Long-term results of the tension-free vaginal tape (TVT) procedure for surgical treatment of female stress urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct. 2001;2(suppl.):S5
  18. Heidkamp MC, Leong FC, Brubaker L, Russell B. Pudendal denervation affects the structure and function of the striated, urethral sphincter in female rats. Int Urogynecol J Pelvic Floor Dysfunct. 1998;9:88
  19. Kerns JM, Damaser MS, Kane JM, Sakamoto K, Benson JT, Shott S, et al. Effects of pudendal nerve injury in the female rat. Neurourol Urodyn. 2000;19:53

 Study received institutional animal care and use committee approval.

PII: S0022-5347(08)02420-8

doi: 10.1016/j.juro.2008.09.002

The Journal of Urology
Volume 181, Issue 1 , Pages 397-400 , January 2009

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