The Journal of Urology
Volume 180, Issue 6 , Pages 2706-2709 , December 2008

Septins as Diagnostic Markers for a Subset of Human Asthenozoospermia

  • Yoshio Sugino

      Affiliations

    • Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    • Equal study contribution.
    • ,
  • Kentaro Ichioka

      Affiliations

    • Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    • Equal study contribution.
    • ,
  • Takeshi Soda

      Affiliations

    • Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    • ,
  • Masafumi Ihara

      Affiliations

    • Biochemistry and Cell Biology Unit, Kyoto University Graduate School of Medicine, Kyoto, Japan
    • ,
  • Makoto Kinoshita

      Affiliations

    • Biochemistry and Cell Biology Unit, Kyoto University Graduate School of Medicine, Kyoto, Japan
    • ,
  • Osamu Ogawa

      Affiliations

    • Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    • ,
  • Hiroyuki Nishiyama

      Affiliations

    • Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    • Corresponding Author InformationCorrespondence and requests for reprints: Department of Urology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan (telephone: 81-75-751-3337; FAX: 81-75-751-3740)

Received 22 August 2007

References 

  1. World Health Organization Laboratory Manual for the Examination of Human Semen and Semen-Cervical Mucus Interaction. 4th ed.. New York: Cambridge University Press; 1999;
  2. Sturgess JM, Chao J, Wong J, Aspin N, Turner JA. Cilia with defective radial spokes: a cause of human respiratory disease. N Engl J Med. 1979;300:53
  3. Robert M, Gagnon C. Purification and characterization of the active precursor of a human sperm motility inhibitor secreted by the seminal vesicles: identity with semenogelin. Biol Reprod. 1996;55:813
  4. Jarow JP, Sharlip ID, Belker AM, Lipshultz LI, Sigman M, Thomas AJ, et al. Best practice policies for male infertility. J Urol. 2002;167:2138
  5. Escalier D. Knockout mouse models of sperm flagellum anomalies. Hum Reprod Update. 2006;12:449
  6. Ihara M, Kinoshita A, Yamada S, Tanaka H, Tanigaki A, Kitano A, et al. Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa. Dev Cell. 2005;8:343
  7. Kissel H, Georgescu MM, Larisch S, Manova K, Hunnicutt GR, Steller H. The Sept4 septin locus is required for sperm terminal differentiation in mice. Dev Cell. 2005;8:353
  8. Kinoshita A, Noda M, Kinoshita M. Differential localization of septions in the mouse brain. J Comp Neurol. 2000;428:223
  9. Kinoshita M, Field CM, Coughlin ML, Straight AF, Mitchison TJ. Selt- and actin-templated assembly of mammalian septins. Dev Cell. 2002;3:791
  10. Touré A, Lhuillier P, Gossen JA, Kuil CW, Lhôte D, Jégou B, et al. The testis anion transporter 1 (Slc26a8) is required for sperm terminal differentiation and male fertility in the mouse. Hum Mol Genet. 2007;16:1783

 Study received Kyoto University institutional review board approval.

 Supported by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan, Smoking Research Foundation and Takeda Science Foundation.

PII: S0022-5347(08)02058-2

doi: 10.1016/j.juro.2008.08.005

The Journal of Urology
Volume 180, Issue 6 , Pages 2706-2709 , December 2008

Article Tools

* Image Usage & Resolution