The Journal of Urology
Volume 180, Issue 5 , Pages 1898-1903 , November 2008

Participation of Caudal Müllerian Mesenchyma in Prostate Development

  • Yi Cai

      Affiliations

    • Corresponding Author InformationCorrespondence: Department of Physiology, University of Tennessee, 894 Union Ave., Memphis, Tennessee 38103 (telephone: 901-448-7328)

Received 24 March 2008

References 

  1. Ellem SJ, Risbridger GP. Treating prostate cancer: a rationale for targeting local oestrogens. Nat Rev Cancer. 2007;7:621
  2. Price D, Williams-Ashman HG. The accessory reproductive glands of mammals. In:  Young WC editors. Sex and Internal Secretions. 3rd ed.. Baltimore: Williams&Wilkins; 1961;p. 366–448
  3. Allard S, Adin P, Gouedard L, di Clemente N, Josso N, Orgebin-Crist MC, et al. Molecular mechanisms of hormone-mediated Mullerian duct regression: involvement of beta-catenin. Development. 2000;127:3349
  4. Zhan Y, Fujino A, MacLaughlin DT, Manganaro TF, Szotek PP, Arango NA, et al. Mullerian inhibiting substance regulates its receptor/SMAD signaling and causes mesenchymal transition of the coelomic epithelial cells early in Mullerian duct regression. Development. 2006;133:2359
  5. Vainio S, Heikkila M, Kispert A, Chin N, McMahon AP. Female development in mammals is regulated by Wnt-4 signalling. Nature. 1999;397:405
  6. Biason-Lauber A, Konrad D, Navratil F, Schoenle EJ. A WNT4 mutation associated with Mullerian-duct regression and virilization in a 46,XX woman. N Engl J Med. 2004;351:792
  7. Mericskay M, Kitajewski J, Sassoon D. Wnt5a is required for proper epithelial-mesenchymal interactions in the uterus. Development. 2004;131:2061
  8. Torres M, Gomez-Pardo E, Dressler GR, Gruss P. Pax-2 controls multiple steps of urogenital development. Development. 1995;121:4057
  9. Boutin EL, Cunha GR. Does sinus vaginal epithelium persist in the adult mouse vagina?. Dev Dyn. 1996;206:403
  10. Drews U, Sulak O, Schenck PA. Androgens and the development of the vagina. Biol Reprod. 2002;67:1353
  11. Mahoney JJ. Genetic and hormonal determination of prostate development in the female rat. J Exp Zool. 1942;90:413
  12. Sugimura Y, Cunha GR, Norman JT, Shannon JM. Regional differences in the inductive activity of the mesenchyme of the embryonic mouse urogenital sinus. Prostate. 1985;7:253
  13. Cohen RJ, Garrett K, Golding JL, Thomas RB, McNeal JE. Epithelial differentiation of the lower urinary tract with recognition of the minor prostatic glands. Hum Pathol. 2002;33:905
  14. Imperato-McGinley J, Sanchez RS, Spencer JR, Yee B, Vaughan ED. Comparison of the effects of the 5 alpha-reductase inhibitor finasteride and the antiandrogen flutamide on prostate and genital differentiation: dose-response studies. Endocrinology. 1992;131:1149
  15. Cunha GR. Age-dependent loss of sensitivity of female urogenital sinus to androgenic conditions as a function of the epithelia-stromal interaction in mice. Endocrinology. 1975;97:665
  16. Warot X, Fromental-Ramain C, Fraulob V, Chambon P, Dolle P. Gene dosage-dependent effects of the Hoxa-13 and Hoxd-13 mutations on morphogenesis of the terminal parts of the digestive and urogenital tracts. Development. 1997;124:4781
  17. Podlasek CA, Duboule D, Bushman W. Male accessory sex organ morphogenesis is altered by loss of function of Hoxd-13. Dev Dyn. 1997;208:454
  18. Podlasek CA, Clemens JQ, Bushman W. Hoxa-13 gene mutation results in abnormal seminal vesicle and prostate development. J Urol. 1999;161:1655
  19. Drews U, Sulak O, Oppitz M. Immunohistochemical localisation of androgen receptor during sex-specific morphogenesis in the fetal mouse. Histochem Cell Biol. 2001;116:427
  20. Morgan EA, Nguyen SB, Scott V, Stadler HS. Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia. Development. 2003;130:3095
  21. Wolf CJ, Hotchkiss A, Ostby JS, LeBlanc GA, Gray LE. Effects of prenatal testosterone propionate on the sexual development of male and female rats: a dose-response study. Toxicol Sci. 2002;65:71
  22. Greene RR, Ivy AC. The experimental production of intersexuality in the female rat with testosterone. Science. 1937;86:200
  23. Naessany S, Habert R, Picon R. Effects of androgen injections and decapitation on the pituitary-gonadal axis and genital tract of fetal rats at the end of gestation. J Endocrinol. 1981;88:359
  24. Cooke PS, Buchanan DL, Lubahn DB, Cunha GR. Mechanism of estrogen action: lessons from the estrogen receptor-alpha knockout mouse. Biol Reprod. 1998;59:470
  25. vom Saal FS, Timms BG, Montano MM, Palanza P, Thayer KA, Nagel SC, et al. Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses. Proc Natl Acad Sci U S A. 1997;94:2056
  26. Richter CA, Taylor JA, Ruhlen RL, Welshons WV, Vom Saal FS. Estradiol and bisphenol a stimulate androgen receptor and estrogen receptor gene expression in fetal mouse prostate mesenchyme cells. Environ Health Perspect. 2007;115:902
  27. Hayashi N, Sugimura Y, Kawamura J, Donjacour AA, Cunha GR. Morphological and functional heterogeneity in the rat prostatic gland. Biol Reprod. 1991;45:308
  28. Andrews GS. The histology of the human foetal and prepubertal prostates. J Anat. 1951;85:44
  29. Adams JY, Leav I, Lau KM, Ho SM, Pflueger SM. Expression of estrogen receptor beta in the fetal, neonatal, and prepubertal human prostate. Prostate. 2002;52:69
  30. Shapiro E, Huang H, Masch RJ, McFadden DE, Wilson EL, Wu XR. Immunolocalization of estrogen receptor alpha and beta in human fetal prostate. J Urol. 2005;174:2051
  31. Wernert N, Albrech M, Sesterhenn I, Goebbels R, Bonkhoff H, Seitz G, et al. The ‘female prostate': location, morphology, immunohistochemical characteristics and significance. Eur Urol. 1992;22:64
  32. McCluggage WG, Ganesan R, Hirschowitz L, Miller K, Rollason TP. Ectopic prostatic tissue in the uterine cervix and vagina: report of a series with a detailed immunohistochemical analysis. Am J Surg Pathol. 2006;30:209
  33. Shapiro E, Huang HY, Wu XR. Uroplakin and androgen receptor expression in the human fetal genital tract: insights into the development of the vagina. J Urol. 2000;164:1048
  34. Ganesan A, Smith GH, Broome K, Steinberg A. Congenital adrenal hyperplasia: preliminary observations of the urethra in 9 cases. J Urol. 2002;167:275
  35. Shibata Y, Ito K, Suzuki K, Nakano K, Fukabori Y, Suzuki R, et al. Changes in the endocrine environment of the human prostate transition zone with aging: simultaneous quantitative analysis of prostatic sex steroids and comparison with human prostatic histological composition. Prostate. 2000;42:45
  36. McNeal JE. Origin and evolution of benign prostatic enlargement. Invest Urol. 1978;15:340
  37. Feneley MR, Puddefoot JR, Xia S, Sowter C, Slavin G, Kirby RS, et al. Zonal biochemical and morphological characteristics in BPH. Br J Urol. 1995;75:608
  38. Wernert N, Gerdes J, Loy V, Seitz G, Scherr O, Dhom G. Investigations of the estrogen (ER-ICA-test) and the progesterone receptor in the prostate and prostatic carcinoma on immunohistochemical basis. Virchows Arch A Pathol Anat Histopathol. 1988;412:387
  39. Krieg M, Bartsch W, Thomsen M, Voigt KD. Androgens and estrogens: their interaction with stroma and epithelium of human benign prostatic hyperplasia and normal prostate. J Steroid Biochem. 1983;19:155
  40. el Etreby MF. Atamestane: an aromatase inhibitor for the treatment of benign prostatic hyperplasia (A short review). J Steroid Biochem Mol Biol. 1993;44:565
  41. Jin B, Turner L, Walters WA, Handelsman DJ. The effects of chronic high dose androgen or estrogen treatment on the human prostate. J Clin Endocrinol Metab. 1996;81:4290
  42. Casella R, Bubendorf L, Schaefer DJ, Bachmann A, Gasser TC, Sulser T. Does the prostate really need androgens to grow? (Transurethral resection of the prostate in a male-to-female transsexual 25 years after sex-changing operation). Urol Int. 2005;75:288
  43. Bierhoff E, Walljasper U, Hofmann D, Vogel J, Wernert N, Pfeifer U. Morphological analogies of fetal prostate stroma and stromal nodules in BPH. Prostate. 1997;31:234
  44. Glenister TW. The development of the utricle and of the so-called ‘middle' or ‘median' lobe of the human prostate. J Anat. 1962;96:443
  45. Stephens FD. Congenital malformations of the rectum, anus and genito-urinary tracts. Edinburgh: E&S Livingstone; 1963;
  46. Meikle AW, Stephenson RA, Lewis CM, Middleton RG. Effects of age and sex hormones on transition and peripheral zone volumes of prostate and benign prostatic hyperplasia in twins. J Clin Endocrinol Metab. 1997;82:571
  47. Tang J, Yang JC, Zhang Y, Liu X, Zhang L, Wang Z, et al. Does benign prostatic hyperplasia originate from the peripheral zone of the prostate? (A preliminary study). BJU Int. 2007;100:1091
  48. Price D. Comparative aspects of development and structure in the prostate. Natl Cancer Inst Monogr. 1963;12:1
  49. Dubbink HJ, Hoedemaeker RF, van der Kwast TH, Schroder FH, Romijn JC. Human prostate-specific transglutaminase: a new prostatic marker with a unique distribution pattern. Lab Invest. 1999;79:141
  50. Thielen JL, Volzing KG, Collier LS, Green LE, Largaespada DA, Marker PC. Markers of prostate region-specific epithelial identity define anatomical locations in the mouse prostate that are molecularly similar to human prostate cancers. Differentiation. 2007;75:49

PII: S0022-5347(08)01828-4

doi: 10.1016/j.juro.2008.07.025

The Journal of Urology
Volume 180, Issue 5 , Pages 1898-1903 , November 2008

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