The Journal of Urology
Volume 180, Issue 5 , Pages 2234-2240 , November 2008

The Beneficial Effect of Coenzyme Q10 and Lipoic Acid on Obstructive Bladder Dysfunction in the Rabbit

  • Yung-Shun Juan

      Affiliations

    • Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China
    • ,
  • Robert M. Levin

      Affiliations

    • Stratton Veterans Affairs Medical Center, Albany, New York
    • ,
  • Shu Mien Chuang

      Affiliations

    • Kaohsiung Municipal Hsiao-Kang Hospital, Graduate Institute of Medicine, College of Medicine and Department of Urology, Taiwan, Republic of China
    • ,
  • Tasmina Hydery

      Affiliations

    • Albany College of Pharmacy, Albany, New York
    • ,
  • Suning Li

      Affiliations

    • First Affiliated Hospital of Zhengzhou University, Henan, People's Republic of China
    • ,
  • Barry Kogan

      Affiliations

    • Albany Medical College, Albany, New York
    • ,
  • Catherine Schuler

      Affiliations

    • First Affiliated Hospital of Zhengzhou University, Henan, People's Republic of China
    • Albany College of Pharmacy, Albany, New York
    • ,
  • Chun-Hsiung Huang

      Affiliations

    • Kaohsiung Municipal Hsiao-Kang Hospital, Graduate Institute of Medicine, College of Medicine and Department of Urology, Taiwan, Republic of China
    • ,
  • Anita Mannikarottu

      Affiliations

    • Albany College of Pharmacy, Albany, New York
    • Albany Medical College, Albany, New York
    • Corresponding Author InformationCorrespondence: Albany College of Pharmacy, 106 New Scotland Ave., Albany, New York 12208 (telephone: 518-445-7306; FAX: 518-445-7248)

Received 14 February 2008

References 

  1. Frei B, Kim MC, Ames BN. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proc Natl Acad Sci U S A. 1990;87:4879
  2. Turunen M, Swiezewska E, Chojnacki T, Sindelar P, Dallner G. Regulatory aspects of coenzyme Q metabolism. Free Radic Res. 2002;36:437
  3. Rosenfeldt F, Marasco S, Lyon W, Wowk M, Sheeran F, Bailey M, et al. Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue. J Thorac Cardiovasc Surg. 2005;129:25
  4. Tarnopolsky MA, Beal MF. Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders. Ann Neurol. 2001;49:561
  5. Levin RM, Borow A, Levin SS, Haugaard N. Effect of DHLA on response of isolated rat urinary bladder to repetitive field stimulation. Mol Cell Biochem. 2003;246:129
  6. Coombes JS, Powers SK, Hamilton KL, Demirel HA, Shanely RA, Zergeroglu MA, et al. Improved cardiac performance after ischemia in aged rats supplemented with vitamin E and alpha-lipoic acid. Am J Physiol Regul Integr Comp Physiol. 2000;279:R2149
  7. Dulundu E, Ozel Y, Topaloglu U, Sehirli O, Ercan F, Gedik N, et al. Alpha-lipoic acid protects against hepatic ischemia-reperfusion injury in rats. Pharmacology. 2007;79:163
  8. Levin RM, Danek M, Whitbeck C, Haugaard N. Effect of ethanol on the response of the rat urinary bladder to in vitro ischemia: protective effect of alpha-lipoic acid. Mol Cell Biochem. 2005;271:133
  9. Greenland JE, Brading AF. The effect of bladder outflow obstruction on detrusor blood flow changes during the voiding cycle in conscious pigs. J Urol. 2001;165:245
  10. Nevel-McGarvey CA, Levin RM, Haugaard N, Wu X, Hudson AP. Mitochondrial involvement in bladder function and dysfunction. Mol Cell Biochem. 1999;194:1
  11. Dalle-Donne I, Rossi R, Giustarini D, Milzani A, Colombo R. Protein carbonyl groups as biomarkers of oxidative stress. Clin Chim Acta. 2003;329:23
  12. Conners W, Whitebeck C, Chicester P, Legget R, Lin AD, Johnson A, et al. L-NAME, a nitric oxide synthase inhibitor, diminishes oxidative damage in urinary bladder partial outlet obstruction. Am J Physiol Renal Physiol. 2006;290:F357
  13. Levin RM, Hudson AP. The molecular genetic basis of mitochondrial malfunction in bladder tissue following outlet obstruction. J Urol. 2004;172:438
  14. Crestanello JA, Doliba NM, Doliba NM, Babsky AM, Niborii K, Osbakken MD, et al. Effect of coenzyme Q10 supplementation on mitochondrial function after myocardial ischemia reperfusion. J Surg Res. 2002;102:221
  15. Maulik N, Yoshida T, Engelman RM, Bagchi D, Otani H, Das DK. Dietary coenzyme Q(10) supplement renders swine hearts resistant to ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2000;278:H1084
  16. Julien JP, Mushynski WE. Neurofilaments in health and disease. Prog Nucleic Acid Res Mol Biol. 1998;61:1
  17. Moon Y, Lee KH, Park JH, Geum D, Kim K. Mitochondrial membrane depolarization and the selective death of dopaminergic neurons by rotenone: protective effect of coenzyme Q10. J Neurochem. 2005;93:1199
  18. Muller U, Krieglstein J. Prolonged pretreatment with alpha-lipoic acid protects cultured neurons against hypoxic, glutamate-, or iron-induced injury. J Cereb Blood Flow Metab. 1995;15:624
  19. Juan YS, Lin WY, Kalorin C, Kogan B, Levin RM, Mannikarottu A. The effect of partial bladder outlet obstruction on carbonyl and nitrotyrosine distribution in rabbit bladder. Urology. 2007;70:1249
  20. Ischiropoulos H. Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species. Arch Biochem Biophys. 1998;356:1

 Study received approval from the institutional animal care and use committee, Stratton Veterans Affairs Medical Center, Albany, New York.

 Supported in part by the Office of Research and Development of the Department of Veterans Affairs, National Institutes of Health Grant RO-1-DK067114.

PII: S0022-5347(08)01819-3

doi: 10.1016/j.juro.2008.07.022

The Journal of Urology
Volume 180, Issue 5 , Pages 2234-2240 , November 2008

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