The Journal of Urology
Volume 180, Issue 5 , Pages 2241-2246 , November 2008

Effects of Estrogen, Raloxifene and Levormeloxifene on α1A-Adrenergic Receptor Expression

  • Lia Banie
    • ,
  • Guiting Lin
    • ,
  • Hongxiu Ning
    • ,
  • Guifang Wang
    • ,
  • Tom F. Lue

      Affiliations

    • Financial interest and/or other relationship with Pfizer, Lilly, Bayer, Medtronic and Urodynix.
    • ,
  • Ching-Shwun Lin

      Affiliations

    • Corresponding Author InformationCorrespondence: Department of Urology, School of Medicine, University of California-San Francisco, San Francisco, California 94143-0738 (telephone: 415-476-3800; FAX: 415-476-3803)

Received 25 January 2008

References 

  1. Norton P, Brubaker L. Urinary incontinence in women. Lancet. 2006;367:57
  2. Gibbs CF, Johnson TM, Ouslander JG. Office management of geriatric urinary incontinence. Am J Med. 2007;120:211
  3. Dooley Y, Kenton K, Cao G, Luke A, Durazo-Arvizu R, Kramer H, et al. Urinary incontinence prevalence: results from the National Health and Nutrition Examination Survey. J Urol. 2007;179:656
  4. Goldstein SR, Johnson S, Watts NB, Ciaccia AV, Elmerick D, Muram D. Incidence of urinary incontinence in postmenopausal women treated with raloxifene or estrogen. Menopause. 2005;12:160
  5. Hendrix SL, Cochrane BB, Nygaard IE, Handa VL, Barnabei VM, Iglesia C, et al. Effects of estrogen with and without progestin on urinary incontinence. JAMA. 2005;293:935
  6. Steinauer JE, Waetjen LE, Vittinghoff E, Subak LL, Hulley SB, Grady D, et al. Postmenopausal hormone therapy: does it cause incontinence?. Obstet Gynecol. 2005;106:940
  7. Draper MW. An update on raloxifene. Int J Gynecol Cancer. 2006;2(suppl):502
  8. Goldstein SR, Nanavati N. Adverse events that are associated with the selective estrogen receptor modulator levormeloxifene in an aborted phase III osteoporosis treatment study. Am J Obstet Gynecol. 2002;187:521
  9. Waetjen LE, Brown JS, Modelska K, Blackwell T, Vittinghoff E, Cummings SR. Effect of raloxifene on urinary incontinence: a randomized controlled trial. Obstet Gynecol. 2004;103:261
  10. Nishimatsu H, Moriyama N, Hamada K, Ukai Y, Yamazaki S, Kameyama S, et al. Contractile responses to alpha1-adrenoceptor agonists in isolated human male and female urethra. BJU Int. 1999;84:515
  11. Taki N, Taniguchi T, Okada K, Moriyama N, Muramatsu I. Evidence for predominant mediation of alpha1-adrenoceptor in the tonus of entire urethra of women. J Urol. 1999;162:1829
  12. Anderson KE. Pharmacology of lower urinary tract smooth muscles and penile erectile tissues. Pharmacol Rev. 1993;45:253
  13. Takahashi H, Takeda M, Shimura H, Kanai T, Obara K, Komeyama T, et al. Alpha-1 adrenoceptor subtypes in the human female urethra-RT-PCR, in situ hybridization, and quantitative autoradiography. Neurourol Urodyn. 1996;15:342
  14. Hatano A, Takahashi H, Tamaki M, Komeyama T, Koizumi T, Takeda M. Pharmacological evidence of distinct alpha 1-adrenoceptor subtypes mediating the contraction of human prostatic urethra and peripheral artery. Br J Pharmacol. 1994;113:723
  15. Zubairy S, Oesterreich S. Estrogen-repressed genes—key mediators of estrogen action?. Breast Cancer Res. 2005;7:163
  16. Zhang Y, Davidge ST. Effect of estrogen replacement on vasoconstrictor responses in rat mesenteric arteries. Hypertension. 1999;34:1117
  17. Sievert KD, Bakircioglu ME, Tsai T, Dahms SE, Nunes L, Lue TF. The effect of simulated birth trauma and/or ovariectomy on rodent continence mechanism. Part I: functional and structural change. J Urol. 2001;166:311
  18. Michelotti GA, Bauman MJ, Smith MP, Schwinn DA. Cloning and characterization of the rat alpha 1a-adrenergic receptor gene promoter (Demonstration of cell specificity and regulation by hypoxia). J Biol Chem. 2003;278:8693
  19. Blakeman PJ, Hilton P, Bulmer JN. Oestrogen and progesterone receptor expression in the female lower urinary tract, with reference to oestrogen status. BJU Int. 2000;86:32
  20. Salmi S, Santti R, Gustafsson JA, Makela S. Co-localization of androgen receptor with estrogen receptor beta in the lower urinary tract of the male rat. J Urol. 2001;166:674

 Study received approval from the institutional committee on animal research.

 Supported by grants from the California Urology Foundation, Mr. Arthur Rock and the Rock Foundation, and the National Institutes of Health.

PII: S0022-5347(08)01811-9

doi: 10.1016/j.juro.2008.07.020

The Journal of Urology
Volume 180, Issue 5 , Pages 2241-2246 , November 2008

Article Tools

* Image Usage & Resolution