The Journal of Urology
Volume 180, Issue 4 , Pages 1367-1372 , October 2008

Daily Cranberry Juice for the Prevention of Asymptomatic Bacteriuria in Pregnancy: A Randomized, Controlled Pilot Study

  • Deborah A. Wing

      Affiliations

    • Department of Obstetrics and Gynecology, University of California, Irvine, Orange, California
    • Corresponding Author InformationCorrespondence: Department of Obstetrics-Gynecology, University of California, Irvine, 101 The City Drive South, Suite 800, Bldg. 56, Orange, California 92868 (telephone: 714-456-5967; FAX: 714-456-7754)
    • Financial interest and/or other relationship with National Institute of Diabetes and Digestive and Kidney Diseases.
    • ,
  • Pamela J. Rumney

      Affiliations

    • Department of Obstetrics and Gynecology, University of California, Irvine, Orange, California
    • ,
  • Christine W. Preslicka

      Affiliations

    • Long Beach Memorial Medical Center and Miller's Children's Hospital, Long Beach, California
    • ,
  • Judith H. Chung

      Affiliations

    • Department of Obstetrics and Gynecology, University of California, Irvine, Orange, California

Received 28 December 2007

References 

  1. Duff P. Pyelonephritis in pregnancy. Clin Obstet Gynecol. 1984;27:17
  2. Stenqvist K, Dahlen-Nilsson I, Lidin-Janson G, Lincoln K, Oden A, Rignell S, et al. Bacteriuria in pregnancy: frequency and risk of acquisition. Am J Epidemiol. 1989;129:372
  3. Patterson TF, Andriole VT. Detection, significance, and therapy of bacteriuria in pregnancy (Update in the managed health care era). Infect Dis Clin North Am. 1997;11:593
  4. Gilstrap LC, Ramin SM. Urinary tract infections during pregnancy. Obstet Gynecol Clin North Am. 2001;28:581
  5. Romero R, Oyarsun E, Mazor M, Sitori M, Hobbins JC, Bracken M. Meta-analysis of the relationship between asymptomatic bacteriuria and preterm delivery/low birth weight. Obstet Gynecol. 1989;73:576
  6. Kincaid-Smith P, Buller M. Bacteriuria in pregnancy. Lancet. 1965;1:395
  7. McGrady GA, Daling JR, Peterson DR. Maternal urinary tract infection and adverse fetal outcomes. Am J Epidemiol. 1985;121:377
  8. Kass EH. Bacteriuria and pyelonephritis of pregnancy. Arch Intern Med. 1960;105:194
  9. Jepson RG, Mihaljevic L, Craig J. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2001;3:CD001321
  10. Jepson RG, Craig JC. A systematic review of the evidence for cranberries and blueberries in UTI prevention. Mol Nutr Food Res. 2007;51:738
  11. U.S. Preventive Services Task Force. Screening for asymptomatic bacteriuria (Guide to clinical preventive services, 2nd edition, 1996). http://www.ahcpr.gov/clinic/uspstfix.htmAccessed March 2008
  12. Foo L, Lu Y, Howell AB, Vorsa N. A-Type proanthocyanidin trimers from cranberry that inhibit adherence of uropathogenic P-fimbriated Escherichia coli. J Nat Prod. 2000;63:1225
  13. Gupta K, Chou MY, Howell A, Wobbe C, Grady R, Stapleton AE. Cranberry products inhibit adherence of p-fimbriated Escherichia coli to primary cultured bladder and vaginal epithelial cells. J Urol. 2007;177:2357
  14. Jepson RG, Craig J. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2008;1:CD001321
  15. Stothers L. A randomized trial to evaluate effectiveness and cost effectiveness of naturopathic cranberry products as prophylaxis against urinary tract infection in women. Can J Urol. 2002;9:1558
  16. Kontiokari T, Sundqvist K, Nuutinen M, Pokka T, Koskela M, Uhari M. Randomised trial of cranberry-lingonberry juice and Lactobacillus GG drink for the prevention of urinary tract infections in women. BMJ. 2001;322:1571
  17. Waites KB, Canupp KC, Armstrong S, DeVivo MJ. Effect of cranberry extract on bacteriuria and pyuria in persons with neurogenic bladder secondary to spinal cord injury. J Spinal Cord Med. 2004;27:35
  18. McMurdo ME, Bissett LY, Price RJ, Phillips G, Crombie IK. Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? (A double-blind, placebo-controlled trial). Age Ageing. 2005;34:256
  19. Foda MM, Middlebrook PF, Garfield CT, Potvin G, Wells G, Schilling JF. Efficacy of cranberry in prevention of urinary tract infections in a susceptible pediatric population. Can J Urol. 1995;2:98
  20. Howell AB, Foxman B. Cranberry juice ingestion and adhesion of antibiotic-resistant uropathogens. JAMA. 2002;23:187

 Study received institutional review board approval.

 Supported by the National Institute of Diabetes and Digestive and Kidney Diseases R21DK65827-01 and NCCAM NOT-CA-02-014.

 Clinical Trials Registration NCT00093938.

 For another article on a related topic see page 1522.

PII: S0022-5347(08)01547-4

doi: 10.1016/j.juro.2008.06.016

The Journal of Urology
Volume 180, Issue 4 , Pages 1367-1372 , October 2008

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