The Journal of Urology
Volume 180, Issue 4 , Pages 1522-1526 , October 2008

A Biphasic Response From Bladder Epithelial Cells Induced by Catheter Material and Bacteria: An In Vitro Study of the Pathophysiology of Catheter Related Urinary Tract Infection

  • Jessica M.T. Barford

      Affiliations

    • Corresponding Author InformationCorrespondence: Department of Cellular and Molecular Medicine, St. George's, University of London, Cranmer Terrace, London SW17 0RE, United Kingdom (telephone: +44 (0)20 8672 9944)
    • Financial interest and/or other relationship with Bactiguard.
    • ,
  • Yanmin Hu
    • ,
  • Ken Anson
    • ,
  • Anthony R.M. Coates

      Affiliations

    • Financial interest and/or other relationship with Bactiguard.

Received 17 January 2008

References 

  1. Gravel D, Taylor G, Ofner M, Johnston L, Loeb M, Roth VR, et al. Point prevalence survey for healthcare-associated infections within Canadian adult acute-care hospitals. J Hosp Infect. 2007;66:243
  2. Pellizzer G, Mantoan P, Timillero L, Allegranzi B, Fedeli U, Schievano E, et al. Prevalence and risk factors for nosocomial infections in hospitals of the Veneto region, north-eastern Italy. Infection. 2008;36:112
  3. Bouza E, San Juan R, Munoz P, Voss A, Kluytmans J. A European perspective on nosocomial urinary tract infections II. Report on incidence, clinical characteristics and outcome (ESGNI-004 study). European Study Group on Nosocomial Infection. Clin Microbiol Infect. 2001;7:532
  4. Tambyah PA, Maki DG. Catheter-associated urinary tract infection is rarely symptomatic: a prospective study of 1,497 catheterized patients. Arch Intern Med. 2000;160:678
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  6. Tambyah PA, Maki DG. The relationship between pyuria and infection in patients with indwelling urinary catheters: a prospective study of 761 patients. Arch Intern Med. 2000;160:673
  7. Liedberg H, Lundeberg T. Assessment of silver-coated urinary catheter toxicity by cell culture. Urol Res. 1989;17:359
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  11. Funfstuck R, Franke S, Hellberg M, Ott U, Knofel B, Straube E, et al. Secretion of cytokines by uroepithelial cells stimulated by Escherichia coli and Citrobacter spp. Int J Antimicrob Agents. 2001;17:253
  12. Godaly G, Proudfoot AE, Offord RE, Svanborg C, Agace WW. Role of epithelial interleukin-8 (IL-8) and neutrophil IL-8 receptor A in Escherichia coli-induced transuroepithelial neutrophil migration. Infect Immun. 1997;65:3451
  13. Mills M, Meysick KC, O'Brien AD. Cytotoxic necrotizing factor type 1 of uropathogenic Escherichia coli kills cultured human uroepithelial 5637 cells by an apoptotic mechanism. Infect Immun. 2000;68:5869
  14. Mulvey MA, Lopez-Boado YS, Wilson CL, Roth R, Parks WC, Heuser J, et al. Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli. Science. 1998;282:1494
  15. Graham GM, Farrar MD, Cruse-Sawyer JE, Holland KT, Ingham E. Proinflammatory cytokine production by human keratinocytes stimulated with Propionibacterium acnes and P. acnes GroEL. Br J Dermatol. 2004;150:421
  16. Zhou X, Gao DQ, Michalski J, Benitez JA, Kaper JB. Induction of interleukin-8 in T84 cells by Vibrio cholerae. Infect Immun. 2004;72:389
  17. Barford JM, Anson K, Hu Y, Coates AR. A model of catheter-associated urinary tract infection initiated by bacterial contamination of the catheter tip. BJU Int. 2008;102:67
  18. Anderl JN, Zahller J, Roe F, Stewart PS. Role of nutrient limitation and stationary-phase existence in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin. Antimicrob Agents Chemother. 2003;47:1251

 Supported by the Pathology Research Fund (St. George's) (JB).

PII: S0022-5347(08)01543-7

doi: 10.1016/j.juro.2008.06.012

The Journal of Urology
Volume 180, Issue 4 , Pages 1522-1526 , October 2008

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