The Journal of Urology
Volume 180, Issue 3 , Pages 836-843 , September 2008

Clinical Correlates of Renal Angiomyolipoma Subtypes in 209 Patients: Classic, Fat Poor, Tuberous Sclerosis Associated and Epithelioid

  • Brian R. Lane

      Affiliations

    • Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio
    • Nothing to disclose.
    • ,
  • Hakan Aydin

      Affiliations

    • Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio
    • Nothing to disclose.
    • ,
  • Teresa L. Danforth

      Affiliations

    • Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio
    • Nothing to disclose.
    • ,
  • Ming Zhou

      Affiliations

    • Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio
    • Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio
    • Nothing to disclose.
    • ,
  • Erick M. Remer

      Affiliations

    • Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio
    • Imaging Institute, Cleveland Clinic, Cleveland, Ohio
    • Nothing to disclose.
    • ,
  • Andrew C. Novick

      Affiliations

    • Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio
    • Nothing to disclose.
    • ,
  • Steven C. Campbell

      Affiliations

    • Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio
    • Corresponding Author InformationCorrespondence: Section of Urological Oncology, Glickman Urological Institute, Cleveland Clinic Foundation, 9500 Euclid Ave., Desk A100, Cleveland, Ohio 44195 (telephone: 216-444-5595; FAX: 216-636-0770).
    • Financial interest and/or other relationship with Aventis Pharmaceuticals, Pfizer and Novartis Pharmaceuticals.

Received 22 January 2008

References 

  1. Nelson CP, Sanda MG. Contemporary diagnosis and management of renal angiomyolipoma. J Urol. 2002;168:1315
  2. Jinzaki M, Tanimoto A, Narimatsu Y, Ohkuma K, Kurata T, Shinmoto H, et al. Angiomyolipoma: imaging findings in lesions with minimal fat. Radiology. 1997;205:497
  3. Kim JK, Park SY, Shon JH, Cho KS. Angiomyolipoma with minimal fat: differentiation from renal cell carcinoma at biphasic helical CT. Radiology. 2004;230:677
  4. Hafron J, Fogarty JD, Hoenig DM, Li M, Berkenblit R, Ghavamian R. Imaging characteristics of minimal fat renal angiomyolipoma with histologic correlations. Urology. 2005;66:1155
  5. Milner J, McNeil B, Alioto J, Proud K, Rubinas T, Picken M, et al. Fat poor renal angiomyolipoma: patient, computerized tomography and histological findings. J Urol. 2006;176:905
  6. Roma AA, Magi-Galluzzi C, Zhou M. Differential expression of melanocytic markers in myoid, lipomatous, and vascular components of renal angiomyolipomas. Arch Pathol Lab Med. 2007;131:122
  7. Christiano AP, Yang X, Gerber GS. Malignant transformation of renal angiomyolipoma. J Urol. 1999;161:1900
  8. Delgado R, de Leon Bojorge B, Albores-Saavedra J. Atypical angiomyolipoma of the kidney: a distinct morphologic variant that is easily confused with a variety of malignant neoplasms. Cancer. 1998;83:1581
  9. Kawaguchi K, Oda Y, Nakanishi K, Saito T, Tamiya S, Nakahara K, et al. Malignant transformation of renal angiomyolipoma: a case report. Am J Surg Pathol. 2002;26:523
  10. Serrano Frago P, Del Agua Arias Camison C, Gil Sanz MJ, Allue Lopez M, Gonzalvo Ibarra A, Plaza Mas L, et al. Controversies related to epithelioid variant of renal angiomyolipoma: a review of the literature. Urology. 2006;67:846
  11. Roach ES, Gomez MR, Northrup H. Tuberous sclerosis complex consensus conference: revised clinical diagnostic criteria. J Child Neurol. 1998;13:624
  12. Oesterling JE, Fishman EK, Goldman SM, Marshall FF. The management of renal angiomyolipoma. J Urol. 1986;135:1121
  13. Danforth TL, Lane BR, Novick AC. Conservative management of giant symptomatic angiomyolipoma in patients with tuberous sclerosis complex. BJU Int. 2007;100:794
  14. Dickinson M, Ruckle H, Beaghler M, Hadley HR. Renal angiomyolipoma: optimal treatment based on size and symptoms. Clin Nephrol. 1998;49:281
  15. Kutikov A, Fossett LK, Ramchandani P, Tomaszewski JE, Siegelman ES, Banner MP, et al. Incidence of benign pathologic findings at partial nephrectomy for solitary renal mass presumed to be renal cell carcinoma on preoperative imaging. Urology. 2006;68:737
  16. Snyder ME, Bach A, Kattan MW, Raj GV, Reuter VE, Russo P. Incidence of benign lesions for clinically localized renal masses smaller than 7 cm in radiological diameter: influence of sex. J Urol. 2006;176:2391
  17. Lane BR, Babineau D, Kattan MW, Novick AC, Gill IS, Zhou M, et al. A preoperative prognostic nomogram for solid enhancing renal tumors 7 cm or less amenable to partial nephrectomy. J Urol. 2007;178:429
  18. Simpson E, Patel U. Diagnosis of angiomyolipoma using computed tomography-region of interest < or =−10 HU or 4 adjacent pixels < or =−10 HU are recommended as the diagnostic thresholds. Clin Radiol. 2006;61:410
  19. Kim JY, Kim JK, Kim N, Cho KS. CT histogram analysis: differentiation of angiomyolipoma without visible fat from renal cell carcinoma at CT imaging. Radiology. 2008;246:472
  20. Lane BR, Samplaski MK, Herts BR, Zhou M, Novick AC, Campbell SC. Renal mass biopsy: a renaissance?. J Urol. 2007;179:20
  21. Pecciarini L, Cangi MG, Lo Cunsolo C, Macri' E, Dal Cin E, Martignoni G, et al. Characterization of t(6;11)(p21;q12) in a renal-cell carcinoma of an adult patient. Genes Chromosomes Cancer. 2007;46:419
  22. Hwang JJ, Uchio EM, Linehan WM, Walther MM. Hereditary kidney cancer. Urol Clin North Am. 2003;30:831
  23. Jimenez RE, Eble JN, Reuter VE, Epstein JI, Folpe AL, de Peralta-Venturina M, et al. Concurrent angiomyolipoma and renal cell neoplasia: a study of 36 cases. Mod Pathol. 2001;14:157

 Editor's Note: This article is the second of 5 published in this issue for which category 1 CME credits can be earned. Instructions for obtaining credits are given with the questions on pages 1196 and 1197.

PII: S0022-5347(08)01277-9

doi: 10.1016/j.juro.2008.05.041

The Journal of Urology
Volume 180, Issue 3 , Pages 836-843 , September 2008

Article Tools

* Image Usage & Resolution