Association of Gadolinium Based Magnetic Resonance Imaging Contrast Agents and Nephrogenic Systemic Fibrosis

Purpose

We investigated the recently discovered association between gadolinium based magnetic resonance imaging contrast agents and the development of nephrogenic systemic fibrosis in patients with chronic kidney disease or acute kidney injury.

Materials and Methods

A systematic review of the PubMed® database and publicly available patient databases was performed to characterize nephrogenic systemic fibrosis and its possible association with exposure to gadolinium based magnetic resonance imaging contrast agents.

Results

Data from case series reports, nephrogenic systemic fibrosis patient databases, nephrogenic systemic fibrosis case reporting to the Food and Drug Administration after gadolinium contrast agent exposure and retrospective case control studies suggest a strong association between the use of gadolinium based magnetic resonance imaging contrast agents and the subsequent development of nephrogenic systemic fibrosis in patients with renal disease. These data also suggest that the risk of nephrogenic systemic fibrosis depends on the degree of renal dysfunction, dose of contrast agent, gadolinium contrast agent stability and severity of concomitant illness. Thus, the occurrence of nephrogenic systemic fibrosis after gadolinium contrast agent exposure may vary from negligible up to 2% to 5% in select high risk clinical situations.

Conclusions

Magnetic resonance imaging using gadolinium based contrast agents must be performed judiciously in patients with renal dysfunction, carefully weighing on a case by case basis the benefits of magnetic resonance imaging and the risk of nephrogenic systemic fibrosis as well as the disadvantages of undergoing alternative or foregoing imaging studies.

Key Words: gadolinium, kidney diseases, magnetic resonance imaging

Abbreviations and Acronyms: AKI, acute kidney injury, CKD, chronic kidney disease, CT, computed tomography, ESRD, end stage renal disease, FDA, Food and Drug Administration, GBMCA, gadolinium based MRI contrast agent, GFR, glomerular filtration rate, IV, intravenous, MRA, magnetic resonance angiography, MRI, magnetic resonance imaging, NFD, nephrogenic fibrosing dermopathy, NSF, nephrogenic systemic fibrosis