The Journal of Urology
Volume 179, Issue 5, Supplement , Pages S14-S18, May 2008

Watchful Waiting and Health Related Quality of Life for Patients With Localized Prostate Cancer: Data From CaPSURE

  • Shelley A. Arredondo

      Affiliations

    • Department of Urology, Urology Outcomes Research Group, University of California, San Francisco Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California
    • ,
  • Tracy M. Downs

      Affiliations

    • Department of Urology, Urology Outcomes Research Group, University of California, San Francisco Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California
    • ,
  • Deborah P. Lubeck

      Affiliations

    • Department of Urology, Urology Outcomes Research Group, University of California, San Francisco Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California
    • ,
  • David J. Pasta

      Affiliations

    • Department of Urology, Urology Outcomes Research Group, University of California, San Francisco Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California
    • Financial interest and/or other relationship with TAP Pharmaceuticals.
    • ,
  • Stefanie J. Silva

      Affiliations

    • Department of Urology, Urology Outcomes Research Group, University of California, San Francisco Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California
    • Financial interest and/or other relationship with TAP Pharmaceuticals.
    • ,
  • Katrine L. Wallace

      Affiliations

    • TAP Pharmaceutical Products, Inc., Lake Forest, Illinois
    • Financial interest and/or other relationship with TAP Pharmaceuticals.
    • ,
  • Peter R. Carroll

      Affiliations

    • Department of Urology, Urology Outcomes Research Group, University of California, San Francisco Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California
    • Financial interest and/or other relationship with TAP Pharmaceuticals, Pfizer, iMetrikus, Aventis, National Cancer Institute, AstraZeneca and Merck.
    • Corresponding Author InformationCorrespondence: Box 0738, 400 Parnassus Ave., San Francisco, California 94143 (telephone: 415-476-8843; FAX: 415-476-8849).

Received 21 May 2004

Abstract 

Purpose

Watchful waiting is an alternative to active treatment for men with low risk prostate cancer but it is unclear how health related quality of life (HRQoL) may change over time for men who select this option. We report on HRQoL in men with localized prostate cancer who selected watchful waiting.

Materials and Methods

HRQoL outcomes were reviewed for 310 men diagnosed with prostate cancer from 1990 to 2001 within Cancer of the Prostate Strategic Urological Research Endeavor who chose watchful waiting. The UCLA Prostate Cancer Index and RAND 36-Item Health Survey were completed at enrollment and approximately every 6 months. A random slopes model was developed to assess time trends in HRQoL for up to 5 years after diagnosis, adjusting for age at diagnosis and specific comorbidities.

Results

Significant decreases with time were observed in 7 domains of the RAND 36-Item Health Survey and 4 of the UCLA Prostate Cancer Index scales.

Conclusions

Men with prostate cancer who chose watchful waiting in the current study had better or similar HRQoL outcomes compared to men without prostate cancer at the start of the study. Many of these scores were significantly affected by increasing age and decreased with time. The physical domain scores as well as sexual function scores decreased more than expected from the aging process alone.

Key Words: quality of life, prostatic neoplasms, outcome assessment

No full text is available. To read the body of this article, please view the PDF online.

 

 CaPSURE is supported by TAP Pharmaceutical Products, Inc. (Lake Forest, Illinois).

 Nothing to disclose.

 Editor’s Note: This article is the first of 5 published in this issue for which category 1 CME credits can be earned. Instructions for obtaining credits are given with the questions on pages 2116 and 2117.

PII: S0022-5347(08)00733-7

doi:10.1016/j.juro.2008.03.132

The Journal of Urology
Volume 179, Issue 5, Supplement , Pages S14-S18, May 2008

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