The Journal of Urology
Volume 180, Issue 1 , Pages 19-30 , July 2008

Surgical Renal Ischemia: A Contemporary Overview

  • Matthew N. Simmons
    • ,
  • Martin J. Schreiber
    • ,
  • Inderbir S. Gill

      Affiliations

    • Corresponding Author InformationCorresponding Author: Section of Laparoscopic and Robotic Surgery, Glickman Urological Institute, Cleveland Clinic Foundation, 9500 Euclid Ave., A100, Cleveland, Ohio 44195 (telephone: 216-445-1534; FAX: 216-445-7031).

Received 27 September 2007

References 

  1. Bhayani SB, Rha KH, Pinto PA, Ong AM, Allaf ME, Trock BJ, et al. Laparoscopic partial nephrectomy: effect of warm ischemia on serum creatinine. J Urol. 2004;172:1264
  2. Desai MM, Gill IS, Ramani AP, Spaliviero M, Rybicki L, Kaouk JH. The impact of warm ischaemia on renal function after laparoscopic partial nephrectomy. BJU Int. 2005;95:377
  3. Lane BR, Gill IS. 5-Year outcomes of laparoscopic partial nephrectomy. J Urol. 2007;177:70
  4. Saranchuk JW, Touijer AK, Hakimian P, Snyder ME, Russo P. Partial nephrectomy for patients with a solitary kidney: the Memorial Sloan-Kettering experience. BJU Int. 2004;94:1323
  5. Silva P. Energy and fuel substrate metabolism in the kidney. Semin Nephrol. 1990;10:432
  6. Sheridan AM, Bonventre JV. Cell biology and molecular mechanisms of injury in ischemic acute renal failure. Curr Opin Nephrol Hypertens. 2000;9:427
  7. Moreira PL, An YH. Animal models for therapeutic embolization. Cardiovasc Intervent Radiol. 2003;26:100
  8. Halasz NA, Elsner R, Garvie RS, Grotke GT. Renal recovery from ischemia: a comparative study of harbor seal and dog kidneys. Am J Physiol. 1974;227:1331
  9. Jablonski P, Howden BO, Rae DA, Birrell CS, Marshall VC, Tange J. An experimental model for assessment of renal recovery from warm ischemia. Transplantation. 1983;35:198
  10. Orvieto MA, Tolhurst SR, Chuang MS, Lyon MB, Ritch CR, Rapp DE, et al. Defining maximal renal tolerance to warm ischemia in porcine laparoscopic and open surgery model. Urology. 2005;66:1111
  11. Tsuji Y, Ariyoshi A, Sakamoto K. An experimental model for unilateral ischaemic acute renal failure in dog. Int Urol Nephrol. 1993;25:83
  12. Haug CE, Lopez IA, Moore RH, Rubin RH, Tolkoff-Rubin N, Palacios deCaretta N, et al. Real-time monitoring of renal function during ischemic injury in the rhesus monkey. Ren Fail. 1995;17:489
  13. Laven BA, Orvieto MA, Chuang MS, Ritch CR, Murray P, Harland RC, et al. Renal tolerance to prolonged warm ischemia time in a laparoscopic versus open surgery porcine model. J Urol. 2004;172:2471
  14. Myers BD, Miller DC, Mehigan JT, Olcott CO, Golbetz H, Robertson CR, et al. Nature of the renal injury following total renal ischemia in man. J Clin Invest. 1984;73:329
  15. Gill IS, Kavoussi LR, Lane BR, Blute ML, Babineau D, Colombo JR, et al. Comparison of 1,800 laparoscopic and open partial nephrectomies for single renal tumors. J Urol. 2007;178:41
  16. Fergany AF, Saad IR, Woo L, Novick AC. Open partial nephrectomy for tumor in a solitary kidney: experience with 400 cases. J Urol. 2006;175:1630
  17. Gill IS, Colombo JR, Moinzadeh A, Finelli A, Ukimura O, Tucker K, et al. Laparoscopic partial nephrectomy in solitary kidney. J Urol. 2006;175:454
  18. Lin J, Knight EL, Hogan ML, Singh AK. A comparison of prediction equations for estimating glomerular filtration rate in adults without kidney disease. J Am Soc Nephrol. 2003;14:2573
  19. Levey AS, Coresh J, Balk E, Kausz AT, Levin A, Steffes MW, et al. National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med. 2003;139:137
  20. Huang WC, Levey AS, Serio AM, Snyder M, Vickers AJ, Raj GV, et al. Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study. Lancet Oncol. 2006;7:735
  21. Cisek LJ, Gobet RM, Peters CA. Pneumoperitoneum produces reversible renal dysfunction in animals with normal and chronically reduced renal function. J Endourol. 1998;12:95
  22. Doty JM, Saggi BH, Blocher CR, Fakhry I, Gehr T, Sica D, et al. Effects of increased renal parenchymal pressure on renal function. J Trauma. 2000;48:874
  23. Orvieto MA, Zorn KC, Mendiola F, Lyon MB, Mikhail AA, Gofrit ON, et al. Recovery of renal function after complete renal hilar versus artery alone clamping during open and laparoscopic surgery. J Urol. 2007;177:2371
  24. Glanemann M, Vollmar B, Nussler AK, Schaefer T, Neuhaus P, Menger MD. Ischemic preconditioning protects from hepatic ischemia/reperfusion-injury by preservation of microcirculation and mitochondrial redox-state. J Hepatol. 2003;38:59
  25. Craddock GN. Species differences in response to renal ischemia. Arch Surg. 1976;111:582
  26. Hebert LA, Stuart KA, Stemper JA. Effect of renal decapsulation on renal function. Am J Physiol. 1975;229:632
  27. Nguyen MM, Gill IS. Halving warm ischemia time during laparoscopic partial nephrectomy. J Urol. 2007;179:227
  28. Novick AC. Renal hypothermia: in vivo and ex vivo. Urol Clin North Am. 1983;10:637
  29. Orvieto MA, Zorn KC, Lyon MB, Tohurst SR, Rapp DE, Mikhail AA, et al. Laparoscopic ice slurry coolant for renal hypothermia. J Urol. 2007;177:382
  30. Steffens J, Humke U, Ziegler M, Siemer S. Partial nephrectomy with perfusion cooling for imperative indications: a 24-year experience. BJU Int. 2005;96:608
  31. Thompson RH, Frank I, Lohse CM, Saad IR, Fergany A, Zincke H, et al. The impact of ischemia time during open nephron sparing surgery on solitary kidneys: a multi-institutional study. J Urol. 2007;177:471
  32. Fornage M, Mosley TH, Jack CR, de Andrade M, Kardia SL, Boerwinkle E, et al. Family-based association study of matrix metalloproteinase-3 and -9 haplotypes with susceptibility to ischemic white matter injury. Hum Genet. 2007;120:671
  33. Akhter SA, D'Souza KM, Petrashevskaya NN, Mialet-Perez J, Liggett SB. Myocardial beta1-adrenergic receptor polymorphisms affect functional recovery after ischemic injury. Am J Physiol Heart Circ Physiol. 2006;290:H1427
  34. Shirasaki Y, Saika T, Tsushima T, Nasu Y, Arata R, Kumon H. Predicting postoperative renal insufficiency in patients undergoing nephrectomy for renal malignancy: assessment by renal scintigraphy using 99mtechnetium-mercaptoacetyltriglycine. J Urol. 2005;173:388
  35. Trof RJ, Di Maggio F, Leemreis J, Groeneveld AB. Biomarkers of acute renal injury and renal failure. Shock. 2006;26:245
  36. Lytton B, Glazier WB, Chaudry IH, Baue AE. The use of adenosine triphosphate with magnesium chloride in the treatment of post ischemic renal injury. Trans Am Assoc Genitourin Surg. 1978;70:145
  37. Brasile L, Stubenitsky BM, Booster MH, Lindell S, Araneda D, Buck C, et al. Overcoming severe renal ischemia: the role of ex vivo warm perfusion. Transplantation. 2002;73:897
  38. Solmazgul E, Uzun G, Cermik H, Atasoyu EM, Aydinoz S, Yildiz S. Hyperbaric oxygen therapy attenuates renal ischemia/reperfusion injury in rats. Urol Int. 2007;78:82
  39. Stollings JL, Oyen LJ. Oxygen therapeutics: oxygen delivery without blood. Pharmacotherapy. 2006;26:1453
  40. O'Hara JF, Hsu TH, Sprung J, Cywinski JB, Rolin HA, Novick AC. The effect of dopamine on renal function in solitary partial nephrectomy surgery. J Urol. 2002;167:24
  41. Tome LA, Yu L, de Castro I, Campos SB, Seguro AC. Beneficial and harmful effects of L-arginine on renal ischaemia. Nephrol Dial Transplant. 1999;14:1139
  42. Aravindan N, Samuels J, Riedel B, Shaw A. Fenoldopam improves corticomedullary oxygen delivery and attenuates angiogenesis gene expression in acute ischemic renal injury. Kidney Blood Press Res. 2006;29:165
  43. Atessahin A, Yilmaz S, Karahan I, Ceribasi AO, Karaoglu A. Effects of lycopene against cisplatin-induced nephrotoxicity and oxidative stress in rats. Toxicology. 2005;212:116
  44. Karaman A, Turkmen E, Gursul C, Tas E, Fadillioglu E. Prevention of renal ischemia/reperfusion-induced injury in rats by leflunomide. Int J Urol. 2006;13:1434
  45. Rosenberger C, Heyman SN, Rosen S, Shina A, Goldfarb M, Griethe W, et al. Up-regulation of HIF in experimental acute renal failure: evidence for a protective transcriptional response to hypoxia. Kidney Int. 2005;67:531
  46. Mishra J, Mori K, Ma Q, Kelly C, Yang J, Mitsnefes M, et al. Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol. 2004;15:3073
  47. Gong H, Wang W, Kwon TH, Jonassen T, Li C, Ring T, et al EPO and alpha-MSH prevent ischemia/reperfusion-induced down-regulation of AQPs and sodium transporters in rat kidney. Kidney Int. 2004;66:683
  48. Chiao H, Kohda Y, McLeroy P, Craig L, Housini I, Star RA. Alpha-melanocyte-stimulating hormone protects against renal injury after ischemia in mice and rats. J Clin Invest. 1997;99:1165
  49. Morigi M, Benigni A, Remuzzi G, Imberti B. The regenerative potential of stem cells in acute renal failure. Cell Transplant. 2006;15(suppl.):S111
  50. Hodges SJ, Atala A. Initial clinical results of the bioartificial kidney containing human cells in ICU patients with acute renal failure. Curr Urol Rep. 2006;7:41

 For another article on a related topic see page 388.

 Editor's Note: This article is the first of 5 published in this issue for which category 1 CME credits can be earned. Instructions for obtaining credits are given with the questions on pages 418 and 419.

PII: S0022-5347(08)00582-X

doi: 10.1016/j.juro.2008.03.022

The Journal of Urology
Volume 180, Issue 1 , Pages 19-30 , July 2008

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