The Journal of Urology
Volume 180, Issue 1 , Pages 373-378 , July 2008

Neural Control of Substance P Induced Up-Regulation and Release of Macrophage Migration Inhibitory Factor in the Rat Bladder

  • Pedro L. Vera

      Affiliations

    • Corresponding Author InformationCorrespondence: Research and Development (151), Bay Pines Veterans Affairs Healthcare System, 10000 Bay Pines Blvd., Bay Pines, Florida 33744 (telephone: 727-398-6661, extension 7384; FAX: 727-398-9467).
    • ,
  • Xihai Wang
    • ,
  • Katherine L. Meyer-Siegler

Received 11 October 2007

References 

  1. Morand EF. New therapeutic target in inflammatory disease: macrophage migration inhibitory factor. Intern Med J. 2005;35:419
  2. Meyer-Siegler KL, Ordorica RC, Vera PL. Macrophage migration inhibitory factor is upregulated in an endotoxin-induced model of bladder inflammation in rats. J Interferon Cytokine Res. 2004;24:55
  3. Meyer-Siegler KL, Vera PL. Substance P induced release of macrophage migration inhibitory factor from rat bladder epithelium. J Urol. 2004;171:1698
  4. Meyer-Siegler KL, Iczkowski KA, Vera PL. Macrophage migration inhibitory factor is increased in the urine of patients with urinary tract infection: macrophage migration inhibitory factor-protein complexes in human urine. J Urol. 2006;175:1523
  5. Meyer-Siegler KL, Vera PL. Intraluminal antibodies to macrophage migration inhibitory factor decrease substance P induced inflammatory changes in the rat bladder and prostate. J Urol. 2004;172:1504
  6. Meyer-Siegler KL, Vera PL. Substance P induced changes in CD74 and CD44 in the rat bladder. J Urol. 2005;173:615
  7. Vera PL, Iczkowski KA, Leng L, Bucala R, Meyer-Siegler KL. Macrophage migration inhibitory factor is released as a complex with alpha1-inhibitor-3 in the intraluminal fluid during bladder inflammation in the rat. J Urol. 2005;174:338
  8. Vera PL, Meyer-Siegler KL. Substance P induces localization of MIF/alpha1-inhibitor-3 complexes to umbrella cells via paracellular transit through the urothelium in the rat bladder. BMC Urol. 2006;6:24
  9. Lecci A, Giuliani S, Lazzeri M, Benaim G, Turini D, Maggi CA. The behavioral response induced by intravesical instillation of capsaicin rats is mediated by pudendal urethral sensory fibers. Life Sci. 1994;55:429
  10. Henry R, Patterson L, Avery N, Tanzola R, Tod D, Hunter D, et al. Absorption of alkalized intravesical lidocaine in normal and inflamed bladders: a simple method for improving bladder anesthesia. J Urol. 2001;165:1900
  11. Hegde SS, Mandel DA, Wilford MR, Briaud S, Ford AP, Eglen RM. Evidence for purinergic neurotransmission in the urinary bladder of pithed rats. Eur J Pharmacol. 1998;349:75
  12. Jeong MS, Lee JG. The role of spinal and peripheral alpha1- and alpha2-adrenoceptors on bladder activity induced by bladder distension in anaesthetized rat. BJU Int. 2000;85:925
  13. Castrillon PO, Cardinali DP, Arce A, Cutrera RA, Esquifino AI. Interferon-gamma release in sympathetically denervated rat submaxillary lymph nodes. Neuroimmunomodulation. 2000;8:197
  14. Esquifino AI, Castrillon PO, Arce A, Cutrera RA, Cardinali DP. Effect of parasympathetic decentralization on interferon-gamma release from rat submandibular lymph nodes in vitro. Auton Neurosci. 2001;91:10
  15. Pongratz G, Harle P, Schnellinger G, Janele D, Scholmerich J, Straub RH. Norepinephrine in mice inhibits secretion of splenic IL-6 during the dark period but stimulates its secretion in the light period–possible role of the corticosterone tone. J Neuroimmunol. 2005;158:120
  16. Wesselmann U. Neurogenic inflammation and chronic pelvic pain. World J Urol. 2001;19:180
  17. Vera PL, Iczkowski KA, Moldwin RM, Kushner L, Meyer-Siegler KL. Macrophage migration inhibitory factor and its receptor (CD74) are upregulated in the urothelium of interstitial cystitis patients. J Urol. 2006;175(suppl.):95;abstract 287
  18. Kushner L, Chiu PY, Brettschneider N, Lipstein A, Eisenberg E, Rofeim O, et al. Urinary substance P concentration correlates with urinary frequency and urgency in interstitial cystitis patients treated with intravesical dimethyl sulfoxide and not intravesical anesthetic cocktail. Urology. 2001;57:129

 Study received local institutional animal care and use committee approval.

 Supported by the Department of Veterans Affairs Merit Award program (PLV, KLMS), National Institute of Diabetes and Digestive and Kidney Diseases DK075059 (XW, PLV, KLMS) and Bay Pines Foundation.

PII: S0022-5347(08)00533-8

doi: 10.1016/j.juro.2008.02.040

The Journal of Urology
Volume 180, Issue 1 , Pages 373-378 , July 2008

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