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Volume 180, Issue 1 , Pages 367-372 , July 2008

Effects of Dutasteride on Prostate Carcinoma Primary Cultures: A Comparative Study With Finasteride and MK386

Claudio Festuccia
- Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy
- Equal study contribution.
Giovanni Luca Gravina
- Department of Surgery, University of L'Aquila, L'Aquila, Italy
- Equal study contribution.
Paola Muzi
- Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy
Roberto Pomante
- Pathology Department, G. Mazzini Hospital, Teramo, Italy
Adriano Angelucci
- Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy
Carlo Vicentini
- Department of Surgery, University of L'Aquila, L'Aquila, Italy
Mauro Bologna
- Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy
- Department of Basic and Applied Biology, University of L'Aquila, L'Aquila, Italy
- Correspondence: Department of Experimental Medicine, Via Vetoio, Coppito-2, 67100 L'Aquila, Italy (telephone: 39 0862 433527; FAX: 39 0862 433523).

Received 24 September 2007

Prostate epithelial cells characterization in culture. A, light microscope shows isolated primary prostate epithelial cell culture from representative patient sample with characteristic cobblestone mo

Prostate epithelial cells characterization in culture. A, light microscope shows isolated primary prostate epithelial cell culture from representative patient sample with characteristic cobblestone morphology associated with epithelial cell cultures. There was no morphological evidence of contaminating fibroblast/stromal cells. Reduced from ×100. B, primary prostate cancer epithelial cells expressed cytokeratin 18 (K18), SDR5A1 (SR1) and SDRA2 (SR2) on Western blot.
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