The Journal of Urology
Volume 179, Issue 6 , Pages 2103-2110 , June 2008

Animal Models of Female Stress Urinary Incontinence

  • Adonis Hijaz

      Affiliations

    • Department of Urology, Case Western Reserve University, Cleveland, Ohio
    • Financial interest and/or other relationship with Pfizer.
    • ,
  • Firouz Daneshgari

      Affiliations

    • Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio
    • ,
  • Karl-Dietrich Sievert

      Affiliations

    • Department of Urology, Eberhard-Karls-University Tuebingen, Tuebingen, Germany
    • ,
  • Margot S. Damaser

      Affiliations

    • Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio
    • Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio
    • Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio
    • Corresponding Author InformationCorrespondence: Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Ave., ND20, Cleveland, Ohio 44195 (telephone: 1-216-444-1103; FAX: 1-216-444-9198).

Received 18 June 2007

References 

  1. Lin AS, Carrier S, Morgan DM, Lue TF. Effect of simulated birth trauma on the urinary continence mechanism in the rat. Urology. 1998;52:143
  2. Sievert KD, Emre Bakircioglu M, Tsai T, Dahms SE, Nunes L, Lue TF. The effect of simulated birth trauma and/or ovariectomy on rodent continence mechanism (Part I: functional and structural change). J Urol. 2001;166:311
  3. Cannon TW, Damaser MS. Effects of anesthesia on cystometry and leak point pressure of the female rat. Life Sci. 2001;69:1193
  4. Damaser MS, Kim FJ, Minetti GM. Methods of testing urethral resistance in the female rat. Adv Exp Med Biol. 2003;539:831
  5. Lee JY, Cannon TW, Pruchnic R, Fraser MO, Huard J, Chancellor MB. The effects of periurethral muscle-derived stem cell injection on leak point pressure in a rat model of stress urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct. 2003;14:31
  6. Kamo I, Cannon TW, Conway DA, Torimoto K, Chancellor MB, de Groat WC, et al. The role of bladder-to-urethral reflexes in urinary continence mechanisms in rats. Am J Physiol Renal Physiol. 2004;287:F434
  7. Rodriguez LV, Chen S, Jack GS, de Almeida F, Lee KW, Zhang R. New objective measures to quantify stress urinary incontinence in a novel durable animal model of intrinsic sphincter deficiency. Am J Physiol Regulat Integr Comp Physiol Regulat Integr Comp Physiol. 2005;288:R1332
  8. Kamo I, Torimoto K, Chancellor MB, de Groat WC, Yoshimura N. Urethral closure mechanisms under sneeze-induced stress condition in rats: a new animal model for evaluation of stress urinary incontinence. Am J Physiol Regulat Integr Comp Physiol. 2003;285:R356
  9. Kaiho Y, Kamo I, Chancellor MB, Arai Y, de Groat WC, Yoshimura N. Role of noradrenergic pathways in sneeze-induced urethral continence reflex in rats. Am J Physiol Renal Physiol. 2007;292:F639
  10. Phull H, Salkini M, Escobar C, Purves T, Comiter CV. The role of angiotensin II in stress urinary incontinence: a rat model. Neurourol Urodyn. 2007;26:81
  11. Damaser MS, Broxton-King C, Ferguson C, Kim FJ, Kerns JM. Functional and neuroanatomical effects of vaginal distention and pudendal nerve crush in the female rat. J Urol. 2003;170:1027
  12. Pan HQ, Kerns JM, Lin DL, Liu S, Esparza N, Damaser MS. Increased duration of simulated childbirth injuries results in increased time to recovery. Am J Physiol Regul Integr Comp Physiol. 2007;292:R1738
  13. Hijaz A, Daneshgari F, Cannon T, Damaser M. Efficacy of a vaginal sling procedure in a rat model of stress urinary incontinence. J Urol. 2004;172:2065
  14. Hijaz A, Bena J, Daneshgari F. Long-term efficacy of a vaginal sling procedure in a rat model of stress urinary incontinence. J Urol. 2005;173:1817
  15. Peng CW, Chen JJ, Chang HY, de Groat WC, Cheng CL. External urethral sphincter activity in a rat model of pudendal nerve injury. Neurourol Urodyn. 2006;25:388
  16. Kuo HC. Effects of vaginal trauma and oophorectomy on the continence mechanism in rats. Urol Int. 2002;69:36
  17. Sievert KD, Bakircioglu ME, Tsai T, Nunes L, Lue TF. The effect of labor and/or ovariectomy on rodent continence mechanism—the neuronal changes. World J Urol. 2004;22:244
  18. Scaldazza CV, Morosetti C. Effect of different sized transurethral catheters on pressure-flow studies in women with lower urinary tract symptoms. Urol Int. 2005;75:21
  19. Kwon D, Kim Y, Pruchnic R, Jankowski R, Usiene I, de Miguel F, et al. Periurethral cellular injection: comparison of muscle-derived progenitor cells and fibroblasts with regard to efficacy and tissue contractility in an animal model of stress urinary incontinence. Urology. 2006;68:449
  20. Conway DA, Kamo I, Yoshimura N, Chancellor MB, Cannon TW. Comparison of leak point pressure methods in an animal model of stress urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct. 2005;16:359
  21. Takahashi S, Chen Q, Ogushi T, Fujimura T, Kumagai J, Matsumoto S, et al. Periurethral injection of sustained release basic fibroblast growth factor improves sphincteric contractility of the rat urethra denervated by botulinum-A toxin. J Urol. 2006;176:819
  22. Resplande J, Gholami SS, Graziottin TM, Rogers R, Lin CS, Leng W, et al. Long-term effect of ovariectomy and simulated birth trauma on the lower urinary tract of female rats. J Urol. 2002;168:323
  23. Bae JH, Moon DG, Lee JG. The effects of a selective noradrenaline reuptake inhibitor on the urethra: an in vitro and in vivo study. BJU Int. 2001;88:771
  24. Cannon TW, Wojcik EM, Ferguson CL, Saraga S, Thomas C, Damaser MS. Effects of vaginal distension on urethral anatomy and function. BJU Int. 2002;90:403
  25. Ferguson CL, Lin DL, Rao S, Damaser MS. Short-term functional and neuroregenerative response of the urethra to ovariectomy and vaginal distension in female rats. Int Urogynecol J Pelvic Floor Dysfunct. 2005;16:119
  26. Kamo I, Kaiho Y, Canon TW, Chancellor MB, de Groat WC, Prantil RL, et al. Functional analysis of active urethral closure mechanisms under sneeze induced stress condition in a rat model of birth trauma. J Urol. 2006;176:2711
  27. Damaser MS, Whitbeck C, Chichester P, Levin RM. Effect of vaginal distension on blood flow and hypoxia of urogenital organs of the female rat. J Appl Physiol. 2005;98:1884
  28. Woo LL, Hijaz A, Kuang M, Penn MS, Damaser MS, Rackley RR. Over expression of stem cell homing cytokines in urogenital organs following vaginal distention. J Urol. 2007;177:1568
  29. Bakircioglu ME, Sievert KD, Lau A, Lin CS, Lue TF. The effect of pregnancy and delivery on the function and ultrastructure of the rat bladder and urethra. BJU Int. 2000;85:350
  30. Lin YH, Liu G, Daneshgari F. A mouse model of simulated birth trauma induced stress urinary incontinence. Neurourol Urodyn. 2007;Epub ahead of print
  31. Kane DD, Kerns JM, Lin DL, Damaser MS. Early structural effects of oestrogen on pudendal nerve regeneration in the rat. BJU Int. 2004;93:870
  32. Woo LL, Hijaz A, Mei K, Mal N, Penn MS, Rackley RR, et al. Stem cell homing and functional recovery after simulated childbirth injury in female rats. J Urol. 2007;177:438;abstract 1330
  33. Snooks SJ, Swash M, Henry MM, Setchell M. Risk factors in childbirth causing damage to the pelvic floor innervation. Int J Colorectal Dis. 1986;1:20
  34. Benson JT. Neurophysiology of the female pelvic floor. Curr Opin Obstet Gynecol. 1994;6:320
  35. Tetzschner T, Sorensen M, Jonsson L, Lose G, Christiansen J. Delivery and pudendal nerve function. Acta Obstet Gynecol Scand. 1997;76:324
  36. Olsen AL, Ross M, Stansfield RB, Kreiter C. Pelvic floor nerve conduction studies: establishing clinically relevant normative data. Am J Obstet Gynecol. 2003;189:1114
  37. Snooks SJ, Barnes PR, Swash M. Damage to the innervation of the voluntary anal and periurethral sphincter musculature in incontinence: an electrophysiological study. J Neurol Neurosurg Psychiatry. 1984;47:1269
  38. Gregory WT, Lou JS, Stuyvesant A, Clark AL. Quantitative electromyography of the anal sphincter after uncomplicated vaginal delivery. Obstet Gynecol. 2004;104:327
  39. Ahn H, Lin DL, Esparza N, Damaser MS. Short-term timecourse of bilateral pudendal nerve injury on leak-point pressure in female rats. J Rehabil Res Dev. 2005;42:109
  40. Damaser MS, Samplaski MK, Parikh M, Lin DL, Rao S, Kerns JM. Time course of neuroanatomical and functional recovery after bilateral pudendal nerve injury in female rats. Am J Physiol Renal Physiol. 2007;293:F1614
  41. Kerns JM, Damaser MS, Kane JM, Sakamoto K, Benson JT, Shott S, et al. Effects of pudendal nerve injury in the female rat. Neurourol Urodyn. 2000;19:53
  42. Ahmed Y, Lin DL, Ferguson C, Esparza N, Damaser MS. Effect of estrogen on urethral function and nerve regeneration following pudendal nerve crush in the female rat. J Urol. 2006;175:1948
  43. Damaser MS, Lin DL, Kerns JM, Sypert DF, Eggers L, Pan HQ. Urodynamic function and expression of neurotrophins after a maternal childbirth injury model of vaginal distension and pudendal nerve crush in rats. Neurourol Urodyn. 2007;26:696
  44. Kim JH, Huang X, Liu G, Moore C, Bena J, Damaser MS, et al. Diabetes slows the recovery from urinary incontinence due to simulated childbirth in female rats. Am J Physiol Regul Integr Comp Physiol. 2007;293:R950
  45. Chermansky CJ, Cannon TW, Torimoto K, Fraser MO, Yoshimura N, de Groat WC, et al. A model of intrinsic sphincteric deficiency in the rat: electrocauterization. Neurourol Urodyn. 2004;23:166
  46. Kim R, Kerns JM, Liu S, Nagel T, Zaszczurynski P, Lin DL, et al. Striated muscle and nerve fascicle distribution in the female rat urethral sphincter. Anat Rec (Hoboken). 2007;290:145
  47. Kim HL, Gerber GS, Patel RV, Hollowell CM, Bales GT. Practice patterns in the treatment of female urinary incontinence: a postal and internet survey. Urology. 2001;57:45
  48. Leach GE, Dmochowski RR, Appell RA, Blaivas JG, Hadley HR, Luber KM, et al. Female Stress Urinary Incontinence Clinical Guidelines Panel summary report on surgical management of female stress urinary incontinence (The American Urological Association). J Urol. 1997;158:875
  49. Cannon TW, Sweeney DD, Conway DA, Kamo I, Yoshimura N, Sacks M, et al. A tissue-engineered suburethral sling in an animal model of stress urinary incontinence. BJU Int. 2005;96:664
  50. Hijaz A, Daneshgari F, Huang X, Bena J, Liu G, Saffore L, et al. Role of sling integrity in the restoration of leak point pressure in the rat vaginal sling model. J Urol. 2005;174:771
  51. Cannon TW, Lee JY, Somogyi G, Pruchnic R, Smith CP, Huard J, et al. Improved sphincter contractility after allogenic muscle-derived progenitor cell injection into the denervated rat urethra. Urology. 2003;62:958
  52. Chermansky CJ, Tarin T, Kwon DD, Jankowski RJ, Cannon TW, de Groat WC, et al. Intraurethral muscle-derived cell injections increase leak point pressure in a rat model of intrinsic sphincter deficiency. Urology. 2004;63:780
  53. Jack GS, Almeida FG, Zhang R, Alfonso ZC, Zuk PA, Rodriguez LV. Processed lipoaspirate cells for tissue engineering of the lower urinary tract: implications for the treatment of stress urinary incontinence and bladder reconstruction. J Urol. 2005;174:2041
  54. Zeng X, Jack G, Zhang R, Leung J, Wu B, Rodriguez LV. Fibroblats and adipose derived stem cells in the treatment of stress urinary incontinence: comparison of functional outcomes. J Urol. 2007;177:554;abstract 1671
  55. Arnold S. Urinary incontinence in castrated bitches (Part 1: significance, clinical aspects and etiopathogenesis). Schweiz Arch Tierheilk. 1997;139:271
  56. de Groat WC, Fraser MO, Yoshiyama M, Smerin S, Tai C, Chancellor MB, et al. Neural control of the urethra. Scand J Urol Nephrol, suppl. 2001;35:35
  57. Liu X, Zhao Y, Gao J, Pawlyk B, Starcher B, Spencer JA, et al. Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nat Genet. 2004;36:178
  58. Liu X, Zhao Y, Pawlyk B, Damaser M, Li T. Failure of elastic fiber homeostasis leads to pelvic floor disorders. Am J Pathol. 2006;168:519
  59. Liu G, Daneshgari F, Li M, Lin D, Lee U, Li T, et al. Bladder and urethral function in pelvic organ prolapsed lysyl oxidase like-1 knockout mice. BJU Int. 2007;100:414
  60. Drewes PG, Yanagisawa H, Starcher B, Hornstra I, Csiszar K, Marinis SI, et al. Pelvic organ prolapse in fibulin-5 knockout mice: pregnancy-induced changes in elastic fiber homeostasis in mouse vagina. Am J Pathol. 2007;170:578

 Supported in part by National Institutes of Health R21 DK070905, R21 DK070004 and RO1 HD038679, and the Rehabilitation Research and Development Service of the Department of Veterans Affairs and Cleveland Clinic.

PII: S0022-5347(08)00243-7

doi: 10.1016/j.juro.2008.01.096

The Journal of Urology
Volume 179, Issue 6 , Pages 2103-2110 , June 2008

Article Tools