The Journal of Urology
Volume 179, Issue 2 , Pages 485-490 , February 2008

Prevention of Recurrence With Epirubicin and Lactobacillus Casei After Transurethral Resection of Bladder Cancer

  • Seiji Naito

      Affiliations

    • Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • Corresponding Author InformationCorrespondence: Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan (telephone: +81-92-642-5601; FAX: +81-92-642-5618).
    • ,
  • Hirofumi Koga

      Affiliations

    • Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • ,
  • Akito Yamaguchi

      Affiliations

    • Department of Urology, Harasanshin General Hospital, Fukuoka, Japan
    • ,
  • Naohiro Fujimoto

      Affiliations

    • Department of Urology, University of Occupational and Environmental Health, Miyazaki, Japan
    • ,
  • Yoshihiro Hasui

      Affiliations

    • Department of Urology, Kitakyushu and Miyazaki Medical College, Miyazaki, Japan
    • ,
  • Hiroshi Kuramoto

      Affiliations

    • Department of Urology, Moji Rousai Hospital, Miyazaki, Japan
    • ,
  • Atsushi Iguchi

      Affiliations

    • Department of Urology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan
    • ,
  • Naoko Kinukawa

      Affiliations

    • Department of Medical Information on Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • ,
  • Kyushu University Urological Oncology Group

Received 2 May 2007

  • Image Result

    Treatment schedule of EPI-ADM and EPI-ADM plus LC groups. In EPI-ADM group 30 mg EPI-ADM/30 ml saline were given immediately after (within 2 hours), and 1, 3, 4, 6, 8, 10 and 12 weeks (W) after TUR. I

    Treatment schedule of EPI-ADM and EPI-ADM plus LC groups. In EPI-ADM group 30 mg EPI-ADM/30 ml saline were given immediately after (within 2 hours), and 1, 3, 4, 6, 8, 10 and 12 weeks (W) after TUR. In EPI-ADM plus LC group same intravesical instillation schedule was used as in EPI-ADM group plus oral administration of 3 gm LC preparation per day, which was begun within 2 weeks after randomization and continued for 1 year.

  • Image Result
    Recurrence-free survival curves after TUR for superficial bladder cancer in 2 groups. EPI-ADM (epi) plus LC group showed significantly higher recurrence-free survival than EPI-ADM group (p = 0.0234).

    Recurrence-free survival curves after TUR for superficial bladder cancer in 2 groups. EPI-ADM (epi) plus LC group showed significantly higher recurrence-free survival than EPI-ADM group (p = 0.0234).

  • Image Result
    Risk of tumor recurrence in EPI-ADM (epi) plus LC group was clearly decreased, especially in year 1 after TUR, compared to that in EPI-ADM group.

    Risk of tumor recurrence in EPI-ADM (epi) plus LC group was clearly decreased, especially in year 1 after TUR, compared to that in EPI-ADM group.

 Study received local institutional review board approval.

 For another article on a related topic see page 743.

PII: S0022-5347(07)02531-1

doi: 10.1016/j.juro.2007.09.031

The Journal of Urology
Volume 179, Issue 2 , Pages 485-490 , February 2008

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