The Journal of Urology
Volume 179, Issue 2 , Pages 764-769 , February 2008

Abnormal Expression of Differentiation Related Proteins and Proteoglycan Core Proteins in the Urothelium of Patients With Interstitial Cystitis

  • Paul J. Hauser

      Affiliations

    • Department of Urology, College of Medicine, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma
    • ,
  • Mikhail G. Dozmorov

      Affiliations

    • Department of Urology, College of Medicine, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma
    • ,
  • Barbara L. Bane

      Affiliations

    • Department of Pathology, College of Medicine, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma
    • ,
  • Gennady Slobodov

      Affiliations

    • Department of Urology, College of Medicine, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma
    • ,
  • Daniel J. Culkin

      Affiliations

    • Department of Urology, College of Medicine, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma
    • ,
  • Robert E. Hurst

      Affiliations

    • Department of Urology, College of Medicine, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma
    • Department of Biochemistry and Molecular Biology, College of Medicine, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma
    • Corresponding Author InformationCorrespondence: Department of Urology, Oklahoma University Health Sciences Center, 940 S. L. Young Blvd., Oklahoma City, Oklahoma 73104 (telephone; 405-271-3930; FAX: 405-271-3289).
    • Financial interest and/or other relationship with Stellar Pharmaceuticals.

Received 1 May 2007

References 

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  2. Slobodov G, Feloney M, Gran C, Kyker KD, Hurst RE, Culkin DJ. Abnormal expression of molecular markers for bladder impermeability and differentiation in urothelium of interstitial cystitis patients. J Urol. 2004;171:1554
  3. Leiby BE, Landis JR, Propert KJ, Andomaszewski JE. Discovery of morphological subgroups that correlate with severity of symptoms in interstitial cystitis: a proposed biopsy classification system. J Urol. 2007;177:142
  4. Keay S, Seillier-Moiseiwitsch F, Zhang CO, Chai T, Zhang J. Changes in human bladder epithelial cell gene expression associated with interstitial cystitis or antiproliferative factor treatment. Physiol Genomics. 2003;14:107
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  6. Laguna P, Smedts F, Nordling J, Horn T, Bouchelouche K, Hopman A, et al. Keratin expression profiling of transitional epithelium in the painful bladder syndrome/interstitial cystitis. Am J Clin Pathol. 2006;125:105
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  11. Dozmorov MG, Kyker KD, Saban R, Knowlton N, Dozmorov IM, Centola M, et al. Analysis of the interaction of extracellular matrix and phenotype of bladder cancer cells. BMC Cancer. 2006;6:12
  12. Santra M, Mann DM, Mercer EW, Skorski T, Calabretta B, Iozzo RV. Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases. J Clin Invest. 1997;100:149
  13. Droguett R, Cabello-Verrugio C, Riquelme C, Brandan E. Extracellular proteoglycans modify TGF-beta bio-availability attenuating its signaling during skeletal muscle differentiation. Matrix Biol. 2006;25:332
  14. Forsberg E, Kjellen L. Heparan sulfate: lessons from knockout mice. J Clin Invest. 2001;108:175
  15. Zhang D, Kosman J, Carmean N, Grady R, Bassuk JA. FGF-10 and its receptor exhibit bidirectional paracrine targeting to urothelial and smooth muscle cells in the lower urinary tract. Am J Physiol Renal Physiol. 2006;291:F481
  16. Bagai S, Rubio E, Cheng JF, Sweet R, Thomas R, Fuchs E, et al. Fibroblast growth factor-10 is a mitogen for urothelial cells. J Biol Chem. 2002;277:23828
  17. Tash JA, David SG, Vaughan ED, Herzlinger DA. Fibroblast growth factor-7 regulates stratification of the bladder urothelium. J Urol. 2001;166:2536
  18. Ghiselli G, Eichstetter I, Iozzo RV. A role for the perlecan protein core in the activation of the keratinocyte growth factor receptor. Biochem J. 2001;359:153
  19. Li Q, Park PW, Wilson CL, Parks WC. Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury. Cell. 2002;111:635
  20. Apodaca G, Kiss S, Ruiz WG, Meyers S, Zeidel M, Birder L. Disruption of bladder epithelium barrier function after spinal cord injury. Am J Physiol Renal Physiol. 2003;

 Supported by R01 DK069808 (REH), a grant from Stellar Pharmaceuticals, Ltd. (REH) and the Department of Urology.

PII: S0022-5347(07)02493-7

doi: 10.1016/j.juro.2007.09.022

The Journal of Urology
Volume 179, Issue 2 , Pages 764-769 , February 2008

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